An Amino Acid Substitution in the Pore Region of a Glutamate-gated Chloride Channel Enables the Coupling of Ligand Binding to Channel Gating

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

1989 • 7,496 citations

The effect of sodium ions on the electrical activity of the giant axon of the squid

1949 • 3,479 citations

POTENTIAL, IMPEDANCE, AND RECTIFICATION IN MEMBRANES

1943 • 2,733 citations

Mechanism of anion permeation through channels gated by glycine and gamma‐aminobutyric acid in mouse cultured spinal neurones.

1987 • 1,166 citations

Ivermectin and Abamectin

1989 • 837 citations

Nicotinic Acetylcholine Receptor an 9 Å Resolution

1993 • 822 citations

Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans

1994 • 716 citations

A point mutation in a Drosophila GABA receptor confers insecticide resistance

1993 • 552 citations

Chimaeric nicotinic–serotonergic receptor combines distinct ligand binding and channel specificities

1993 • 401 citations

The atypical M2 segment of the beta subunit confers picrotoxinin resistance to inhibitory glycine receptor channels.

1992 • 305 citations

Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors

1995 • 304 citations

Residues within transmembrane segment M2 determine chloride conductance of glycine receptor homo- and hetero-oligomers.

1993 • 239 citations

Cloning and expression of the 58 kd β subunit of the inhibitory glycine receptor

1990 • 237 citations

Structure of nicotinic acetylcholine receptors

1993 • 234 citations

Transient Expression Shows Ligand Gating and Allosteric Potentiation of GABA _A Receptor Subunits

1988 • 233 citations

The Mechanism of Action of Avermectins in Caenorhabditis Elegans: Correlation between Activation of Glutamate-Sensitive Chloride Current, Membrane Binding, and Biological Activity

1995 • 223 citations

The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex

1995 • 205 citations

Single Subunits of the GABA _A Receptor Form Ion Channels with Properties of the Native Receptor

1988 • 193 citations

On the mechanism of action of picrotoxin on GABA receptor channels in dissociated sympathetic neurones of the rat.

1992 • 193 citations

Two types of extrajunctional L‐glutamate receptors in locust muscle fibres.

1976 • 181 citations

The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating.

1995 • 174 citations

A unique amino acid of the Drosophila GABA receptor with influence on drug sensitivity by two mechanisms.

1994 • 160 citations

Expression of a glutamate-activated chloride current in Xenopus oocytes injected with Caenorhabditis elegans RNA: evidence for modulation by avermectin

1992 • 147 citations

Voltage clamping of Xenopus laevis oocytes utilizing agarose-cushion electrodes

1994 • 145 citations

Avermectin-sensitive chloride currents induced by Caenorhabditis elegans RNA in Xenopus oocytes.

1991 • 83 citations

Effect of ibotenic acid on chloride permeability of insect muscle-fibres

1973 • 74 citations

Modeling of agonist binding to the ligand‐gated ion channel superfamily of receptors

1990 • 61 citations

Chloride channels gated by extrajunctional glutamate receptors (H-receptors) on locust leg muscle

1989 • 36 citations