Neurotrophic factors: From structure-function studies to designing effective therapeutics

A Hot Spot of Binding Energy in a Hormone-Receptor Interface

1995 • 1,943 citations

Trophic factors and neuronal survival

1989 • 1,631 citations

The Trk family of neurotrophin receptors

1994 • 1,271 citations

Crystal structure of human chorionic gonadotropin

1994 • 936 citations

Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB

1991 • 847 citations

Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in xenopus ovary

1991 • 836 citations

The changing scene of neurotrophic factors

1991 • 827 citations

Binding of brain-derived neurotrophic factor to the nerve growth factor receptor

1990 • 702 citations

The nerve growth factor family of receptors

1992 • 649 citations

Activation of the Sphingomyelin Cycle Through the Low-Affinity Neurotrophin Receptor

1994 • 583 citations

Nerve growth factor-induced hyperalgesia in the neonatal and adult rat

1993 • 560 citations

Nerve growth factor and nociception

1993 • 530 citations

Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells

1993 • 525 citations

New protein fold revealed by a 2.3-Å resolution crystal structure of nerve growth factor

1991 • 500 citations

The role of neurotrophins in the developing nervous system

1994 • 472 citations

Binding of neurotrophin-3 to its neuronal receptors and interactions with nerve growth factor and brain-derived neurotrophic factor.

1992 • 458 citations

Nerve growth factor mediates signal transduction through trk homodimer receptors

1992 • 458 citations

Neurotrophin-6 is a new member of the nerve growth factor family

1994 • 404 citations

Disruption of NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to TrkA on PC12 cells

1994 • 397 citations

The effect of systemically administered recombinant human nerve growth factor in healthy human subjects

1994 • 394 citations

Arrest of Motor Neuron Disease in wobbler Mice Cotreated with CNTF and BDNF

1994 • 389 citations

Dimerization of B-type Platelet-derived Growth Factor Receptors Occurs After Ligand Binding and Is Closely Associated with Receptor Kinase Activation

1989 • 366 citations

Co-evolution of ligand-receptor pairs

1994 • 340 citations

Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product

1992 • 336 citations

Nerve growth factor administration protects against experimental diabetic sensory neuropathy

1994 • 287 citations

Neurotrophic factor therapy for nervous system degenerative diseases

1994 • 254 citations

Neurotrophin-3 prevents the death of adult central noradrenergic neurons in vivo

1994 • 212 citations

The Therapeutic Potential of Neurotrophic Factors in the Treatment of Parkinson's Disease

1993 • 169 citations

Topological similarities in TGF-β2, PDGF-BB and NGF define a superfamily of polypeptide growth factors

1993 • 155 citations

An extended surface of binding to Trk tyrosine kinase receptors in NGF and BDNF allows the engineering of a multifunctional pan-neurotrophin.

1993 • 151 citations

Role of the phenylalanine B25 side chain in directing insulin interaction with its receptor. Steric and conformational effects.

1986 • 133 citations

The binding epitopes of neurotrophin-3 to its receptors trkC and gp75 and the design of a multifunctional human neurotrophin.

1994 • 111 citations

Chimeric molecules with multiple neurotrophic activities reveal structural elements determining the specificities of NGF and BDNF.

1991 • 111 citations

Structure-function studies of nerve growth factor: functional importance of highly conserved amino acid residues.

1990 • 69 citations

Interactions of neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and the NT-3.BDNF heterodimer with the extracellular domains of the TrkB and TrkC receptors.

1994 • 61 citations

Mutagenesis identifies amino-terminal residues of nerve growth factor necessary for Trk receptor binding and biological activity.

1994 • 58 citations

The amino terminus of nerve growth factor is involved in the interaction with the receptor tyrosine kinase p140trkA

1992 • 58 citations

Role and expression of neurotrophins and the trk family of tyrosine kinase receptors in neural growth and rescue after injury.

1993 • 53 citations

Purification and characterisation of a brain‐derived neurotrophic factor/ neurotrophin‐3 (BDNF/NT‐3) heterodimer

1994 • 51 citations

NGF/BDNF chimeric proteins: analysis of neurotrophin specificity by homolog-scanning mutagenesis

1992 • 50 citations

Formation of heterodimers from three neurotrophins, nerve growth factor, neurotrophin-3, and brain-derived neurotrophic factor.

1994 • 44 citations

Role of variable beta-hairpin loop in determining biological specificities in neurotrophin family.

1994 • 39 citations

The carboxyl terminus of nerve growth factor is required for biological activity.

1993 • 38 citations

Heterodimers of the neurotrophic factors: Formation, isolation, and differential stability

1993 • 34 citations

Neurotrophin-3 acquires NGF-like activity after exchange to five NGF amino acid residues: Molecular analysis of the sites in NGF mediating the specific interaction with the NGF high affinity receptor

1994 • 31 citations

Synergistic Trophic Actions on Rat Basal Forebrain Neurons Revealed by a Synthetic NGF/BDNF Chimaeric Molecule

1995 • 19 citations