Synergistic Trophic Actions on Rat Basal Forebrain Neurons Revealed by a Synthetic NGF/BDNF Chimaeric Molecule

A rapid radiochemical method for the determination of choline acetyltransferase

1975 • 2,406 citations

BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra

1991 • 1,487 citations

Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections

1986 • 1,458 citations

Molecular cloning and expression of brain-derived neurotrophic factor

1989 • 1,453 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF

1990 • 1,261 citations

NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression

1990 • 1,238 citations

Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family

1990 • 1,140 citations

trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3

1991 • 1,078 citations

Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons

1994 • 1,065 citations

Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection.

1986 • 1,063 citations

Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene

1994 • 978 citations

The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3

1991 • 940 citations

Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB

1991 • 847 citations

Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in xenopus ovary

1991 • 836 citations

Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family

1990 • 817 citations

Mammalian subtilisins: The long-sought dibasic processing endoproteases

1991 • 756 citations

Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain.

1990 • 700 citations

Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture

1990 • 684 citations

Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.

1992 • 633 citations

An immunohistochemical study of the nerve growth factor receptor in developing rats

1988 • 610 citations

Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3.

1991 • 610 citations

Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous system

1992 • 592 citations

Widespread Expression of BDNF But Not NT3 by Target Areas of Basal Forebrain Cholinergic Neurons

1990 • 529 citations

Cells Expressing mRNA for Neurotrophins and their Receptors During Embryonic Rat Development

1992 • 499 citations

Nerve growth factor increases choline acetyl-transferase but not survival or fiber outgrowth of cultured fetal septal cholinergic neurons

1985 • 491 citations

Chronic intraventricular injections of nerve growth factor elevate hippocampal choline acetyltransferase activity in adult rats with partial septo-hippocampal lesions

1984 • 446 citations

p140trk mRNA marks NGF-responsive forebrain neurons: Evidence that trk gene expression is induced by NGF

1992 • 371 citations

Development of septal cholinergic neurons in culture: plating density and glial cells modulate effects of NGF on survival, fiber growth, and expression of transmitter-specific enzymes

1988 • 321 citations

Nerve growth factor receptor molecules in rat brain.

1986 • 268 citations

Rescue of lesioned septal cholinergic neurons by nerve growth factor: specificity and requirement for chronic treatment

1988 • 213 citations

Differential Actions of Neurotrophins in the Locus Coeruleus and Basal Forebrain

1993 • 212 citations

Neurotrophin-3 prevents the death of adult central noradrenergic neurons in vivo

1994 • 212 citations

Developmental change in the nerve growth factor action from induction of choline acetyltransferase to promotion of cell survival in cultured basal forebrain cholinergic neurons from postnatal rats

1988 • 208 citations

Cells that Express Brain‐Derived Neurotrophic Factor mRNA in the Developing Postnatal Rat Brain

1991 • 208 citations

Basal forebrain magnocellular neurons stain for nerve growth factor receptor: Correlation with cholinergic cell bodies and effects of axotomy

1987 • 193 citations

Transient and persistent expression of NT-3/HDNF mRNA in the rat brain during postnatal development

1991 • 163 citations

An extended surface of binding to Trk tyrosine kinase receptors in NGF and BDNF allows the engineering of a multifunctional pan-neurotrophin.

1993 • 151 citations

Chimeric molecules with multiple neurotrophic activities reveal structural elements determining the specificities of NGF and BDNF.

1991 • 111 citations

GABAergic and cholinergic neurons exhibit high-affinity nerve growth factor binding in rat basal forebrain

1989 • 60 citations

Temporal and spatial expression of NGF receptor mRNA during postnatal rat brain development analyzed by in situ hybridization

1991 • 39 citations

Localization of nerve growth factor receptor mRNA in the rat basal forebrain within situ hybridization histochemistry

1990 • 19 citations