UK-37,248, A novel, selective thromboxane synthetase inhibitor with platelet anti-aggregatory and anti-thrombotic activity

Aggregation of Blood Platelets by Adenosine Diphosphate and its Reversal

1962 • 4,273 citations

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

1976 • 3,613 citations

Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.

1975 • 3,075 citations

Prostaglandins and Thromboxanes

1978 • 1,310 citations

Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxides

1976 • 1,012 citations

Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac arteries and inhibits platelet aggregation

1976 • 956 citations

Release of Additional Factors in Anaphylaxis and its Antagonism by Anti-inflammatory Drugs

1969 • 886 citations

Low dose aspirin and inhibition of thromboxane B2 production in healthy subjects

1980 • 642 citations

Detection and Isolation of an Endoperoxide Intermediate in Prostaglandin Biosynthesis

1973 • 640 citations

Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides

1976 • 533 citations

Coronary Arterial Smooth Muscle Contraction by a Substance Released from Platelets: Evidence That It Is Thromboxane A ₂

1976 • 504 citations

UNSTABLE METABOLITES OF ARACHIDONIC ACID AND THEIR ROLE IN HAEMOSTASIS AND THROMBOSIS

1978 • 447 citations

Oxygenation of polyunsaturated fatty acids during prostaglandin biosynthesis by sheep vesicular glands

1972 • 362 citations

Further studies on the enzymatic conversion of prostaglandin endoperoxide into prostacyclin by porcine aorta microsomes

1978 • 306 citations

: A selective inhibitor of thromboxane synthetase

1977 • 303 citations

Prostaglandin Synthetase Inhibitors I

1979 • 279 citations

Arachidonic Acid Causes Sudden Death in Rabbits

1974 • 241 citations

Thromboxane release during pacing-induced angina pectoris: possible vasoconstrictor influence on the coronary vasculature.

1980 • 224 citations

Mechanism of prostaglandin biosynthesis. I. Characterization and assay of bovine prostaglandin synthetase

1971 • 190 citations

Platelet and Blood Vessel Arachidonate Metabolism and Interactions

1979 • 181 citations

Prostaglandin Endoperoxides IX. Characterization of Rabbit Aorta Contracting Substance (RCS) from Guinea Pig Lung and Human Platelets

1975 • 179 citations

ADMINISTRATION TO MAN OF UK-37,248-01, A SELECTIVE INHIBITOR OF THROMBOXANE SYNTHETASE

1981 • 168 citations

Detection of thromboxane B2 in peripheral blood of patients with Prinzmetal's angina

1979 • 164 citations

Reduction of hydroperoxides in the prostaglandin biosynthetic pathway by a microsomal peroxidase.

1979 • 162 citations

On the Formation and Effects of Thromboxane A₂ in Human Platelets

1976 • 150 citations

Thromboxane Generation and Platelet Aggregation in Survivals of Myocardial Infarction

1978 • 125 citations

Inhibition of human platelet thromboxane synthetase by 9,11-azoprosta-5,13-dienoic acid.

1977 • 111 citations

Diversion of prostaglandin endoperoxide metabolism by selective inhibition of thromboxane A2 biosynthesis in lung, spleen or platelets

1977 • 106 citations

On the inhibitory potency of imidazole and its derivatives on thromboxane synthetase

1978 • 98 citations

Platelet adhesion and aggregation in diabetes mellitus

1979 • 87 citations

Biosynthesis of thromboxanes in human platelets. I. Characterization and assay of thromboxane systhetase

1977 • 66 citations

Selective inhibition of thromboxane A2 biosynthesis in blood platelets

1977 • 58 citations

Inhibitors of thromboxane synthase in human platelets

1977 • 46 citations

N-0164 inhibits generation of thromboxane-A2-like activity from prostaglandin endoperoxides by human platelet microsomes

1976 • 45 citations

Influence of indomethacin on cation excretion after acute unilateral nephrectomy in dogs

1980 • 38 citations

Inhibition of arachidonic acid induced mortality in rabbits with several non-steroidal anti-inflammatory agents

1977 • 30 citations

An imbalance in arachidonic acid metabolism in diabetes.

1980 • 23 citations

Thromboxane B2 and 6-keto-prostaglandin F1α synthesis during infusion of collagen and arachidonic acid in rabbits: Inhibition by aspirin and sulfinpyrazone

1980 • 20 citations

3-(1-imidazolylmethyl) indoles: potent and selective inhibitors of human blood platelet thromboxane synthetase

1981 • 18 citations

Selective inhibition of thromboxane synthetase by pyridine and its derivatives

1980 • 17 citations

Detection and bioassay of pharmacologically active substances released by arachidonic acid from guinea-pig perfused lungs

1978 • 12 citations

METABOLISM OF ARACHIDONIC ACID AND ITS ENDOPEROXIDE (PGH₂) TO MYOTROPIC PRODUCTS IN GUINEA‐PIG AND RABBIT ISOLATED LUNGS

1980 • 10 citations

Differential synthesis and metabolism of prostaglandins and thromboxanes released from normal and sensitized guinea-pig lungs [proceedings].

1977 • 8 citations

Platelet adhesion and aggregation.

1972 • 6 citations