Basal expression of cyclooxygenase-2 and nuclear factor–interleukin 6 are dominant and coordinately regulated by interleukin 1 in the pancreatic islet

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Fast and sensitive silver staining of DNA in polyacrylamide gels

1991 • 2,914 citations

Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas

1967 • 2,783 citations

Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase.

1993 • 1,655 citations

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

1993 • 1,270 citations

Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids

1993 • 1,222 citations

Prostaglandin synthase 2

1996 • 1,212 citations

The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes.

1990 • 940 citations

Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction.

1994 • 862 citations

Prostaglandin Endoperoxide H Synthases-1 and -2

1996 • 721 citations

Expression of mRNA for cyclooxygenase‐1 and cyclooxygenase‐2 in human tissues

1993 • 708 citations

Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids.

1994 • 661 citations

The role of interleukin-1 in the pathogenesis of IDDM

1996 • 528 citations

The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells

1996 • 304 citations

Demonstration of an inducible cyclooxygenase in human endothelial cells using antibodies raised against the carboxyl-terminal region of the cyclooxygenase-2.

1993 • 293 citations

Constitutive and interleukin-1 (IL-1)-inducible factors interact with the IL-1-responsive element in the IL-6 gene.

1990 • 283 citations

The Endocrine pancreas

1991 • 261 citations

IL-1.beta. induces the coexpression of both nitric oxide synthase and cyclooxygenase by Islets of Langerhans: activation of cyclooxygenase by nitric oxide

1993 • 253 citations

Characterization and hormonal regulation of the promoter of the rat prostaglandin endoperoxide synthase 2 gene in granulosa cells. Identification of functional and protein-binding regions

1993 • 177 citations

Identification of a cyclooxygenase-related gene and its potential role in prostaglandin formation

1989 • 154 citations

A Role for Prostaglandin E in Defective Insulin Secretion and Carbohydrate Intolerance in Diabetes Mellitus

1977 • 144 citations

Structural Determination and Promoter Analysis of the Chicken Mitogen-Inducible Prostaglandin G/H Synthase Gene and Genetic Mapping of the Murine Homolog

1993 • 127 citations

Cytokines activate the nuclear factor κB (NF‐κB) and induce nitric oxide production in human pancreatic islets

1996 • 106 citations

The bimodal effect of interleukin 1 on rat pancreatic beta-cells – stimulation followed by inhibition – depends upon dose, duration of exposure, and ambient glucose concentration

1988 • 101 citations

Induction of Cyclooxygenase-2 and Prostaglandin F_2αReceptor Expression by Interleukin-1β in Cultured Human Granulosa-Luteal Cells¹

1997 • 83 citations

Insulin Secretion and cAMP Metabolism in HIT Cells: Reciprocal and Serial Passage-Dependent Relationships

1989 • 78 citations

Prostaglandin G/H synthase-2 is the constitutive and dominant isoform in cultured human lung epithelial cells

1996 • 78 citations

Cytokine Gene Expression in Pancreatic Islet-Infiltrating Leukocytes of BB Rats: Expression of Th1 Cytokines Correlates With β-Cell Destructive Insulitis and IDDM

1996 • 74 citations

Constitutive and Interleukin-1 (IL-1)-Inducible Factors Interact with the IL-1-Responsive Element in the IL-6 Gene

1990 • 58 citations

Cytokine gene expression in pancreatic islet-infiltrating leukocytes of BB rats: expression of Th1 cytokines correlates with beta-cell destructive insulitis and IDDM

1996 • 53 citations

Arachidonic acid metabolite regulation of insulin secretion

1986 • 49 citations

The cytoplasmic domain of the interleukin-1 receptor is required for nuclear factor-kappa B signal transduction.

1994 • 45 citations

G-Proteins and Hormonal Inhibition of Insulin Secretion From HIT-T15 Cells and Isolated Rat Islets

1992 • 41 citations

Stimulation by prostaglandin E2 of a high-affinity GTPase in the secretory granules of normal rat and human pancreatic islets

1994 • 40 citations

Induction of Cyclooxygenase-2 and Prostaglandin F2 Receptor Expression by Interleukin-1 in Cultured Human Granulosa-Luteal Cells

1997 • 37 citations

Interleukin-1α Exerts Glucose-Dependent Stimulatory and Inhibitory Effects on Islet Cell Phosphoinositide Hydrolysis and Insulin Secretion*

1989 • 26 citations

Short-term exposure of rat pancreatic islets to human interleukin-1β increases cellular uptake of calcium

1990 • 26 citations

Dual Functional Effects of Interleukin-1β on Purine Nucleotides and Insulin Secretion in Rat Islets and INS-1 Cells

1996 • 22 citations

Human interleukin-1? induced stimulation of insulin release from rat pancreatic islets is accompanied by an increase in mitochondrial oxidative events

1989 • 20 citations

Molecular regulation of prostaglandin synthesis

1995 • 17 citations

Interleukin 1 beta-mediated destruction of pancreatic beta-cells in vitro. A model of beta-cell destruction in insulin-dependent diabetes mellitus?

1994 • 7 citations