Molecular pathology of Alzheimer's disease

The American Journal of Human Genetics

1950 • 5,048 citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

1991 • 2,375 citations

Apolipoprotein E polymorphism and atherosclerosis.

1988 • 2,007 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

1992 • 1,723 citations

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

1992 • 1,701 citations

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

1992 • 1,602 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid

1992 • 1,453 citations

Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

1992 • 1,438 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

1993 • 1,329 citations

Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene

1991 • 1,191 citations

A mutation in the Amyloid Precursor Protein Associated with Hereditary Alzheimer's Disease

1991 • 1,121 citations

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.

1988 • 1,073 citations

Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.

1992 • 982 citations

Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14

1992 • 941 citations

Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor

1993 • 909 citations

Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum.

1993 • 901 citations

Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments

1992 • 883 citations

In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity

1991 • 833 citations

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein

1993 • 800 citations

Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage.

1991 • 762 citations

Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the β–amyloid precursor protein gene

1992 • 725 citations

β-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

1990 • 620 citations

βA4 amyloid protein deposition in brain after head trauma

1991 • 465 citations

The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome

1989 • 463 citations

Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14

1992 • 458 citations

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation.

1990 • 453 citations

Alzheimer amyloid protein precursor complexes with brain GTP-binding protein Go

1993 • 430 citations

Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder

1990 • 396 citations

Mapping of a gene predisposing to early–onset Alzheimer's disease to chromosome 14q24.3

1992 • 332 citations

Alzheimer's disease : basic mechanisms, diagnosis and therapeutic strategies

1991 • 327 citations

Phosphorylation of microtubule-associated protein tau: identification of the site for Ca2(+)-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles.

1990 • 298 citations

Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons

1990 • 283 citations

Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European families

1987 • 275 citations

A locus for familial early–onset Alzhelmer's disease on the long arm of chromosome 14, proximal to the α1–antichymotrypsin gene

1992 • 267 citations

In vivo neurotoxicity of beta-amyloid [β(1–40)] and the β(25–35) fragment

1992 • 225 citations

Large amounts of neocortical βA4 deposits without neuritic plaques nor tangles in a psychometrically assessed, non-demented person

1990 • 174 citations

The 717Val→Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups

1991 • 131 citations

Lack of alzheimer pathology after β-amyloid protein injections in rat brain

1992 • 125 citations

Molecular and prospective phenotypic characterization of a pedigree with familial Alzheimer's disease and a missense mutation in codon 717 of the β‐amyloid precursor protein gene

1992 • 123 citations

Hippocampal Neurons Predisposed to Neurofibrillary Tangle Formation Are Enriched in Type II Calcium/Calmodulin-Dependent Protein Kinase

1990 • 112 citations

Clinical comparison of Alzheimer's disease in pedigrees with the codon 717 Val→Ile mutation in the amyloid precursor protein gene

1993 • 90 citations

Association of an apolipoprotein CII allele with familial dementia of the Alzheimer type

1987 • 86 citations

Failure of beta-amyloid protein fragment 25–35 to cause hippocampal damage in the rat

1992 • 72 citations

Implants containing β-amyloid protein are not neurotoxic to young and old rat brain

1992 • 71 citations

Isolation, characterization, and chromosomal localization of human brain cDNA clones coding for the precursor of the amyloid of brain in Alzheimer's disease, Down's syndrome and aging.

1987 • 69 citations

Synthetic amyloid β-protein fails to produce specific neurotoxicity in monkey cerebral cortex

1992 • 60 citations

Age of onset in familial early onset Alzheimer's disease correlates with genetic aetiology

1993 • 45 citations

Toxicity of synthetic aβ peptides and modeling of alzheimer's disease

1992 • 40 citations

Association of an apolipoprotein CII allele with familial dementia of the Alzheimer type

1987 • 39 citations

Evidence for Allelic Heterogeneity in Familial Early-Onset Alzheimer's Disease

1991 • 25 citations

Christ‐Siemens‐Touraine syndrom—a clinical and genetic analysis of a large Brazilian kindred: III. Carrier detection

1979 • 20 citations

Screening for the APP codon mutations in Alzheimer's disease

1993 • 6 citations

Analysis of the beta-amyloid protein precursor of Alzheimer's disease: mRNAs and protein products.

1990 • 5 citations

Meteorological Conditions at the Time of the Eruption of Mount Tarawera, New Zealand

1887 • 3 citations

On some Phenomena connected with the Freezing of Aërated Water

1887 • 2 citations

Chronology of Elasticians

1886 • 2 citations