Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs

1999 • 2,326 citations

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

2000 • 1,596 citations

FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress

2007 • 1,505 citations

Large-scale analysis of the human and mouse transcriptomes

2002 • 1,493 citations

Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements

1998 • 1,460 citations

FOXO transcription factors at the interface between longevity and tumor suppression

2005 • 1,250 citations

The FoxO code

2008 • 1,105 citations

FoxOs Are Lineage-Restricted Redundant Tumor Suppressors and Regulate Endothelial Cell Homeostasis

2007 • 1,018 citations

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

2000 • 983 citations

IL-7 is critical for homeostatic proliferation and survival of naïve T cells

2001 • 940 citations

Suppression of Ovarian Follicle Activation in Mice by the Transcription Factor Foxo3a

2003 • 898 citations

Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells

2007 • 854 citations

Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice

1994 • 835 citations

Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification

2004 • 660 citations

Forkhead Transcription Factor FKHR-L1 Modulates Cytokine-Dependent Transcriptional Regulation of p27^KIP1

2000 • 609 citations

The Forkhead Transcription Factor FoxO Regulates Transcription of p27Kip1 and Bim in Response to IL-2

2002 • 580 citations

Kruppel-like factor 2 regulates thymocyte and T-cell migration

2006 • 527 citations

Suppression of IL7Rα Transcription by IL-7 and Other Prosurvival Cytokines

2004 • 472 citations

Control of Cell Cycle Exit and Entry by Protein Kinase B-Regulated Forkhead Transcription Factors

2002 • 435 citations

Regulation of NF-κB, Th Activation, and Autoinflammation by the Forkhead Transcription Factor Foxo3a

2004 • 407 citations

Forkhead-box transcription factors and their role in the immune system

2004 • 404 citations

FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal

2006 • 392 citations

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

2008 • 383 citations

Control of T Cell Viability

2004 • 367 citations

Naïve and Memory CD4 ⁺ T Cell Survival Controlled by Clonal Abundance

2006 • 348 citations

It takes two to tango

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Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation

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Abnormal Angiogenesis in Foxo1 (Fkhr)-deficient Mice

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γ chain required for naïve CD4+ T cell survival but not for antigen proliferation

2000 • 314 citations

The Role of the Thymus and Recent Thymic Migrants in the Maintenance of the Adult Peripheral Lymphocyte Pool

1998 • 294 citations

Activation of PI3K Is Indispensable for Interleukin 7–mediated Viability, Proliferation, Glucose Use, and Growth of T Cell Acute Lymphoblastic Leukemia Cells

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Foxo1 directly regulates the transcription of recombination-activating genes during B cell development

2008 • 270 citations

Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis

2007 • 215 citations

Convergence of TCR and cytokine signaling leads to FOXO3a phosphorylation and drives the survival of CD4+ central memory T cells

2006 • 209 citations

Distinct Roles of the Phosphatidylinositol 3-Kinase and STAT5 Pathways in IL-7-Mediated Development of Human Thymocyte Precursors

1999 • 205 citations

FOXO-binding partners: it takes two to tango

2008 • 203 citations

Control of Cyclin G2 mRNA Expression by Forkhead Transcription Factors: Novel Mechanism for Cell Cycle Control by Phosphoinositide 3-Kinase and Forkhead

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Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor expression patterns

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Krüppel-Like Factor 2 Controls T Cell Trafficking by Activating L-Selectin (CD62L) and Sphingosine-1-Phosphate Receptor 1 Transcription

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FOXO1 Regulates L-Selectin and a Network of Human T Cell Homing Molecules Downstream of Phosphatidylinositol 3-Kinase

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'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR

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FOXO Transcription Factors as Regulators of Immune Homeostasis: Molecules to Die for?

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SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway

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GA binding protein regulates interleukin 7 receptor α-chain gene expression in T cells

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T lymphocytes need IL-7 but not IL-4 or IL-6 to survive in vivo

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T cell homeostasis: Keeping useful T cells alive and live T cells useful

2005 • 124 citations

Stable Activation of Phosphatidylinositol 3-Kinase in the T Cell Immunological Synapse Stimulates Akt Signaling to FoxO1 Nuclear Exclusion and Cell Growth Control

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Disruption of Peripheral Leptin Signaling in Mice Results in Hyperleptinemia without Associated Metabolic Abnormalities

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Peripheral T cell survival

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Homeostasis of T cell numbers: from thymus production to peripheral compartmentalization and the indexation of regulatory T cells

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Foxo in the immune system

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IL-7 transgenic mice: analysis of the role of IL-7 in the differentiation of thymocytes in vivo and in vitro

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Development of lymphocytes in interleukin 7‐transgenic mice

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Transcriptional Regulation of the Mouse IL-7 Receptor α Promoter by Glucocorticoid Receptor

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Role of interleukin‐7 in bone and T‐cell homeostasis

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Role of the forkhead transcription family member, FKHR, in thymocyte differentiation

2000 • 64 citations

Vav1 Promotes T Cell Cycle Progression by Linking TCR/CD28 Costimulation to FOXO1 and p27kip1 Expression

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Interleukin-7 (IL-7) Knockout Mice. Implications for Lymphopoiesis and Organ-Specific Immunity

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T cell homeostasis requires G protein‐coupled receptor‐mediated access to trophic signals that promote growth and inhibit chemotaxis

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