Therapeutic cancer vaccines

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

2005 • 2,667 citations

Cancer/testis antigens, gametogenesis and cancer

2005 • 1,541 citations

Vaccination with Mage-3a1 Peptide–Pulsed Mature, Monocyte-Derived Dendritic Cells Expands Specific Cytotoxic T Cells and Induces Regression of Some Metastases in Advanced Stage IV Melanoma

1999 • 1,260 citations

Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients

2003 • 981 citations

Immune and clinical responses in patients with metastatic melanoma to CD34(+) progenitor-derived dendritic cell vaccine.

2001 • 828 citations

HUMAN T CELL RESPONSES AGAINST MELANOMA

2005 • 638 citations

Altered peptide ligand vaccination with Flt3 ligand expanded dendritic cells for tumor immunotherapy

2001 • 535 citations

Tumor Progression Can Occur despite the Induction of Very High Levels of Self/Tumor Antigen-Specific CD8+ T Cells in Patients with Melanoma

2005 • 462 citations

Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4+ and CD8+ T cell responses in humans

2004 • 446 citations

Principles and use of anti-CTLA4 antibody in human cancer immunotherapy

2006 • 437 citations

The response of autologous T cells to a human melanoma is dominated by mutated neoantigens

2005 • 427 citations

Vaccination of Metastatic Melanoma Patients With Autologous Tumor-Derived Heat Shock Protein gp96-Peptide Complexes: Clinical and Immunologic Findings

2002 • 387 citations

Cancer immunotherapy with mRNA‐transfected dendritic cells

2004 • 307 citations

Vaccination of Cancer Patients Against Telomerase Induces Functional Antitumor CD8+ T Lymphocytes

2004 • 254 citations

Contrasting frequencies of antitumor and anti-vaccine T cells in metastases of a melanoma patient vaccinated with a MAGE tumor antigen

2005 • 243 citations

Effects of Interleukin-12 on the Immune Response to a Multipeptide Vaccine for Resected Metastatic Melanoma

2001 • 243 citations

Vaccination with autologous tumor-derived heat-shock protein gp96 after liver resection for metastatic colorectal cancer.

2003 • 242 citations

A unique tumor antigen produced by a single amino acid substitution

1995 • 230 citations

Prolonged Survival After Complete Resection of Disseminated Melanoma and Active Immunotherapy With a Therapeutic Cancer Vaccine

2002 • 204 citations

The Immunodominant Antigen of an Ultraviolet-induced Regressor Tumor Is Generated by a Somatic Point Mutation in the DEAD Box Helicase p68

1997 • 148 citations

Immunotherapy of human cancer: lessons from mice

2000 • 143 citations

Adjuvant active specific immunotherapy of stage II and stage III colon cancer with an autologous tumor cell vaccine: first randomized phase III trials show promise

2001 • 133 citations

A point mutation in the alpha-actinin-4 gene generates an antigenic peptide recognized by autologous cytolytic T lymphocytes on a human lung carcinoma.

2001 • 119 citations

High frequency of cytolytic T lymphocytes directed against a tumor-specific mutated antigen detectable with HLA tetramers in the blood of a lung carcinoma patient with long survival.

2001 • 116 citations

Individually distinct transplantation antigens of chemically induced mouse tumors

1988 • 113 citations

Vaccines in cancer: GVAX®, a GM-CSF gene vaccine

2005 • 106 citations

Increased Immunogenicity of an Anchor-Modified Tumor-Associated Antigen Is Due to the Enhanced Stability of the Peptide/MHC Complex: Implications for Vaccine Design

2005 • 105 citations

High Frequency of Autologous Anti-Melanoma CTL Directed Against an Antigen Generated by a Point Mutation in a New Helicase Gene

2000 • 97 citations

A natural cytotoxic T cell response in a spontaneously regressing human melanoma targets a neoantigen resulting from a somatic point mutation

1999 • 80 citations

Cytotoxic T-lymphocyte response to autologous human squamous cell cancer of the lung: epitope reconstitution with peptides extracted from HLA-Aw68.

1994 • 77 citations

Untitled

2000 • 67 citations

A point mutation in the NFYC gene generates an antigenic peptide recognized by autologous cytolytic T lymphocytes on a human squamous cell lung carcinoma

2005 • 63 citations

Do human cancers express sharedprotectiveantigens? or The necessity of remembrance of things past

1996 • 61 citations

Vaccines with Enhanced Costimulation Maintain High Avidity Memory CTL

2005 • 58 citations

The immunoprotective MHC II epitope of a chemically induced tumor harbors a unique mutation in a ribosomal protein

2001 • 40 citations

Immunogenicity without Immunoselection: A Mutant but Functional Antioxidant Enzyme Retained in a Human Metastatic Melanoma and Targeted by CD8+ T Cells with a Memory Phenotype

2005 • 40 citations

Immunotherapy for prostate cancer

2003 • 32 citations

Results of a placebo-controlled phase III trial of immunotherapy with APC8015 for patients with hormone refractory prostate cancer (HRPC)

2005 • 30 citations

A perspective on monoclonal antibody therapy: Where we have been and where we are going

2000 • 17 citations

Autologous tumor-derived HSPPC-96 vs. physician’s choice (PC) in a randomized phase III trial in stage IV melanoma

2006 • 15 citations

Vaccination strategies for lymphomas

2003 • 5 citations