The response of autologous T cells to a human melanoma is dominated by mutated neoantigens

Combination Immunotherapy of B16 Melanoma Using Anti–Cytotoxic T Lymphocyte–Associated Antigen 4 (Ctla-4) and Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf)-Producing Vaccines Induces Rejection of Subcutaneous and Metastatic Tumors Accompanied by Autoimmune Depigmentation

1999 • 1,000 citations

The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas.

1993 • 986 citations

Immune and clinical responses in patients with metastatic melanoma to CD34(+) progenitor-derived dendritic cell vaccine.

2001 • 828 citations

Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma

1996 • 806 citations

T cell defined tumor antigens

1997 • 641 citations

A New Era for Cancer Immunotherapy Based on the Genes that Encode Cancer Antigens

1999 • 578 citations

The Makings of a Tumor Rejection Antigen

1999 • 389 citations

Vaccination of Metastatic Melanoma Patients With Autologous Tumor-Derived Heat Shock Protein gp96-Peptide Complexes: Clinical and Immunologic Findings

2002 • 387 citations

Immunological and clinical responses in metastatic renal cancer patients vaccinated with tumor RNA-transfected dendritic cells.

2003 • 362 citations

Functional avidity maturation of CD8+ T cells without selection of higher affinity TCR

2001 • 349 citations

Rapid cloning of HLA-A,B cDNA by using the polymerase chain reaction: frequency and nature of errors produced in amplification.

1990 • 306 citations

Mutation detection using Surveyor™ nuclease

2004 • 301 citations

A monoclonal cytolytic T-lymphocyte response observed in a melanoma patient vaccinated with a tumor-specific antigenic peptide encoded by geneMAGE-3

2001 • 222 citations

Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors

2001 • 209 citations

High-Avidity CTL Exploit Two Complementary Mechanisms to Provide Better Protection Against Viral Infection Than Low-Avidity CTL

2001 • 207 citations

Immunity against cancer: lessons learned from melanoma

2001 • 190 citations

Durable complete clinical responses in a phase I/II trial using an autologous melanoma cell/dendritic cell vaccine

2003 • 186 citations

A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast

2001 • 163 citations

Correlation between tumor regression and T cell responses in melanoma patients vaccinated with a MAGE antigen

2004 • 155 citations

Immunotherapy: Bewitched, Bothered, and Bewildered No More

2004 • 136 citations

Detection of intracellular expression and secretion of interferon‐γ at the single‐cell level after activation of human T cells with tetanus toxoid in vitro

1990 • 130 citations

The use of HLA-A*0201-transfected K562 as standard antigen-presenting cells for CD8+ T lymphocytes in IFN-γ ELISPOT assays

2002 • 124 citations

High frequency of cytolytic T lymphocytes directed against a tumor-specific mutated antigen detectable with HLA tetramers in the blood of a lung carcinoma patient with long survival.

2001 • 116 citations

Identification of New Melanoma Epitopes on Melanosomal Proteins Recognized by Tumor Infiltrating T Lymphocytes Restricted by HLA-A1, -A2, and -A3 Alleles

1998 • 114 citations

Individually distinct transplantation antigens of chemically induced mouse tumors

1988 • 113 citations

Analysis of antigens recognized on human melanoma cells by A2‐restricted cytolytic t lymphocytes (CTL)

1993 • 101 citations

Cytotoxic T cells directed to tumor antigens not expressed on normal melanocytes dominate HLA-A2.1-restricted immune repertoire to melanoma.

1996 • 90 citations

A natural cytotoxic T cell response in a spontaneously regressing human melanoma targets a neoantigen resulting from a somatic point mutation

1999 • 80 citations

Multiple HLA Class II-Restricted Melanocyte Differentiation Antigens Are Recognized by Tumor-Infiltrating Lymphocytes from a Patient with Melanoma

2002 • 78 citations

Cytotoxic T cells directed to tumor antigens not expressed on normal melanocytes dominate HLA-A2.1-restricted immune repertoire to melanoma.

1996 • 76 citations

Characterization of human cytomegalovirus peptide–specific CD8+ T-cell repertoire diversity following in vitro restimulation by antigen-pulsed dendritic cells

2002 • 71 citations

Characterization of two Epstein‐Barr virus epitopes restricted by HLA‐B7

1995 • 64 citations

Examination of CD8+ T Cell Function in Humans Using MHC Class I Tetramers: Similar Cytotoxicity but Variable Proliferation and Cytokine Production Among Different Clonal CD8+ T Cells Specific to a Single Viral Epitope

2000 • 62 citations

Regulating self-tolerance by deregulating gene expression

2004 • 54 citations

Identification of GP100-derived, melanoma-specific cytotoxic T-lymphocyte epitopes restricted by HLA-A3 supertype molecules by primaryin vitro immunization with peptide-pulsed dendritic cells

1998 • 51 citations

Antitumor Immunity at Work in a Melanoma Patient

1999 • 48 citations

Point Mutation in Essential Genes with Loss or Mutation of the Second Allele

2001 • 47 citations

Analysis of a natural immune response against tumor antigens in a melanoma survivor: lessons applicable to clinical trial evaluations.

2001 • 42 citations

Linking Genomics to Immunotherapy by Reverse Immunology - ‘Immunomics’ in the New Millennium

2001 • 29 citations

Cited By (0)

No citing papers found in database