Activation of Group II Metabotropic Glutamate Receptors in the Nucleus Accumbens Shell Attenuates Context-Induced Relapse to Heroin Seeking

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

The rat brain in stereotaxic coordinates

1983 • 28,962 citations

Autoradiographic localization of dopamine D1 and D2 receptors in rat nucleus accumbens: Resistance to differential rearing conditions

1991 • 3,177 citations

The Neural Basis of Addiction: A Pathology of Motivation and Choice

2005 • 2,660 citations

Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex

2002 • 2,076 citations

Context, time, and memory retrieval in the interference paradigms of Pavlovian learning.

1993 • 1,802 citations

The reinstatement model of drug relapse: history, methodology and major findings

2002 • 1,586 citations

Context, ambiguity, and unlearning: sources of relapse after behavioral extinction

2002 • 1,567 citations

Conditioned place preference: what does it add to our preclinical understanding of drug reward?

2000 • 1,210 citations

Specificity in the projection patterns of accumbal core and shell in the rat

1991 • 1,186 citations

Putting a spin on the dorsal–ventral divide of the striatum

2004 • 1,141 citations

The patterns of afferent innervation of the core and shell in the “Accumbens” part of the rat ventral striatum: Immunohistochemical detection of retrogradely transported fluoro‐gold

1993 • 1,084 citations

Role of unconditioned and conditioned drug effects in the self-administration of opiates and stimulants.

1984 • 1,060 citations

On the significance of subterritories in the “accumbens” part of the rat ventral striatum

1992 • 1,022 citations

Ventral striatal control of appetitive motivation: role in ingestive behavior and reward-related learning

2004 • 915 citations

Multiple Parallel Memory Systems in the Brain of the Rat

2002 • 884 citations

Dopamine and drug addiction: the nucleus accumbens shell connection

2004 • 883 citations

Neurobiology of Relapse to Heroin and Cocaine Seeking: A Review

2002 • 874 citations

Prefrontal Glutamate Release into the Core of the Nucleus Accumbens Mediates Cocaine-Induced Reinstatement of Drug-Seeking Behavior

2003 • 869 citations

Organization of the projections from the subiculum to the ventral striatum in the rat. A study using anterograde transport of Phaseolus vulgaris leucoagglutinin

1987 • 857 citations

The neuropsychological basis of addictive behaviour

2001 • 796 citations

Contextual control of the extinction of conditioned fear

1979 • 786 citations

Metabotropic glutamate receptors: electrophysiological properties and role in plasticity

1999 • 770 citations

Stress-induced relapse to heroin and cocaine seeking in rats: a review

2000 • 695 citations

Methods of Assessing the Reinforcing Properties of Abused Drugs

1987 • 684 citations

Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system.

2001 • 678 citations

Convergence and Segregation of Ventral Striatal Inputs and Outputs

1999 • 669 citations

Psychomotor stimulant addiction: a neural systems perspective.

2002 • 635 citations

Dynamics of Drug Dependence

1973 • 608 citations

The metabotropic glutamate receptors, MGLUR2 and MGLUR3, show unique postsynaptic, presynaptic and glial localizations

1996 • 584 citations

Psychomotor Stimulant Addiction: A Neural Systems Perspective

2002 • 573 citations

Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat

1993 • 554 citations

Glutamate Transmission in the Nucleus Accumbens Mediates Relapse in Cocaine Addiction

2000 • 545 citations

The Role of the Dorsomedial Prefrontal Cortex, Basolateral Amygdala, and Dorsal Hippocampus in Contextual Reinstatement of Cocaine Seeking in Rats

2004 • 518 citations

Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: An in situ hybridization study

1993 • 518 citations

Differential control over cocaine-seeking behavior by nucleus accumbens core and shell

2004 • 478 citations

Classical Conditioning in Drug‐Dependent Humansa

1992 • 473 citations

Dopamine Release in the Dorsal Striatum during Cocaine-Seeking Behavior under the Control of a Drug-Associated Cue

2002 • 462 citations

Molecular Substrates for Retrieval and Reconsolidation of Cocaine-Associated Contextual Memory

2005 • 457 citations

Central amygdala ERK signaling pathway is critical to incubation of cocaine craving

2005 • 445 citations

Addictive and non‐addictive drugs induce distinct and specific patterns of ERK activation in mouse brain

2004 • 432 citations

The accumbens: beyond the core-shell dichotomy

1997 • 415 citations

Control of cocaine-seeking behavior by drug-associated stimuli in rats: Effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbens

2000 • 412 citations

Involvement of the Dorsal Striatum in Cue-Controlled Cocaine Seeking

2005 • 386 citations

Renewal of drug seeking by contextual cues after prolonged extinction in rats.

2002 • 377 citations

The pharmacology of mesolimbic dopamine neurons: a dual-probe microdialysis study in the ventral tegmental area and nucleus accumbens of the rat brain

1996 • 376 citations

Cocaine Experience Establishes Control of Midbrain Glutamate and Dopamine by Corticotropin-Releasing Factor: A Role in Stress-Induced Relapse to Drug Seeking

2005 • 369 citations

Compartmental organization of the ventral striatum of the rat: Immunohistochemical distribution of enkephalin, substance P, dopamine, and calcium‐binding protein

1989 • 359 citations

Cocaine-predictive stimulus induces drug-seeking behavior and neural activation in limbic brain regions after multiple months of abstinence: Reversal by D ₁ antagonists

2001 • 357 citations

The role of the fornix/fimbria and some related subcortical structures in place learning and memory

1989 • 356 citations

Sources of relapse after extinction in Pavlovian and instrumental learning

1991 • 350 citations

Glutamate systems in cocaine addiction

2003 • 349 citations

Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sites

2001 • 338 citations

Rewarding Actions of Phencyclidine and Related Drugs in Nucleus Accumbens Shell and Frontal Cortex

1996 • 331 citations

Second-order schedules of drug reinforcement in rats and monkeys: measurement of reinforcing efficacy and drug-seeking behaviour

2000 • 309 citations

Cocaine Administered into the Medial Prefrontal Cortex Reinstates Cocaine-Seeking Behavior by Increasing AMPA Receptor-Mediated Glutamate Transmission in the Nucleus Accumbens

2002 • 303 citations

Occasion Setting in Pavlovian Conditioning

1992 • 292 citations

Dissociable Effects of Antagonism of NMDA and AMPA/KA Receptors in the Nucleus Accumbens Core and Shell on Cocaine-seeking Behavior

2001 • 287 citations

Sensitization to Morphine Induced by Viral-Mediated Gene Transfer

1997 • 279 citations

Role of conditioned reinforcers in the initiation, maintenance and extinction of drug-seeking behavior

1976 • 248 citations

A Role of Ventral Tegmental Area Glutamate in Contextual Cue-Induced Relapse to Heroin Seeking

2004 • 244 citations

Differential involvement of the core and shell subregions of the nucleus accumbens in conditioned cue-induced reinstatement of cocaine seeking in rats

2004 • 239 citations

Immunohistochemical localization of metabotropic glutamate receptors mGluR1a and mGluR2/3 in the rat basal ganglia

1998 • 237 citations

Preferential Effects of the Metabotropic Glutamate 2/3 Receptor Agonist LY379268 on Conditioned Reinstatement versus Primary Reinforcement: Comparison between Cocaine and a Potent Conventional Reinforcer

2004 • 236 citations

Segregation of Amphetamine Reward and Locomotor Stimulation between Nucleus Accumbens Medial Shell and Core

2003 • 230 citations

The ups and downs of addiction: role of metabotropic glutamate receptors

2004 • 220 citations

Distribution of a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat and mouse: an immunohistochemical study with a monoclonal antibody

1998 • 217 citations

Conducting exposure treatment in multiple contexts can prevent relapse

1998 • 210 citations

Group II Metabotropic Glutamate Receptors Modulate Extracellular Glutamate in the Nucleus Accumbens

2002 • 210 citations

Enduring Resistance to Extinction of Cocaine-Seeking Behavior Induced by Drug-Related Cues

2001 • 203 citations

Clonidine blocks stress‐induced reinstatement of heroin seeking in rats: an effect independent of locus coeruleus noradrenergic neurons

2000 • 199 citations

Dissociable Effects of Lidocaine Inactivation of the Rostral and Caudal Basolateral Amygdala on the Maintenance and Reinstatement of Cocaine-Seeking Behavior in Rats

2002 • 198 citations

Basolateral amygdala inactivation abolishes conditioned stimulus- and heroin-induced reinstatement of extinguished heroin-seeking behavior in rats

2002 • 194 citations

The ventral hippocampus and fear conditioning in rats

2001 • 186 citations

Alterations in behaviour and glutamate transmission following presentation of stimuli previously associated with cocaine exposure

2001 • 160 citations

Effect of Dopamine Receptor Antagonists on Renewal of Cocaine Seeking by Reexposure to Drug-associated Contextual Cues

2002 • 159 citations

Selective memory impairments produced by transient lidocaine-induced lesions of the nucleus accumbens in rats.

1994 • 155 citations

Reinstatement of drug-seeking behavior produced by heroin-predictive environmental stimuli

1997 • 155 citations

The Ventral Hippocampus Supports a Memory Representation of Context and Contextual Fear Conditioning: Implications for a Unitary Function of the Hippocampus.

2005 • 149 citations

Intravenous Self-Administration: Response Rates, the Effects of Pharmacological Challenges, and Drug Preference

1987 • 148 citations

Second-order schedules of drug self-administration in animals

2002 • 146 citations

Glutamate-associated plasticity in the ventral tegmental area is necessary for conditioning environmental stimuli with morphine

2004 • 143 citations

Mapping of chemical trigger zones for reward

2004 • 140 citations

Persistent Cue-Evoked Activity of Accumbens Neurons after Prolonged Abstinence from Self-Administered Cocaine

2003 • 136 citations

Renewal of drug seeking by contextual cues after prolonged extinction in rats.

2002 • 132 citations

The Conditioned Reinforcing Effects of Stimuli Associated with Morphine Reinforcement

1968 • 130 citations

Selective memory impairments produced by transient lidocaine-induced lesions of the nucleus accumbens in rats.

1994 • 118 citations

Spatial localization in the Morris water maze in rats: Acquisition is affected by intra-accumbens injections of the dopaminergic antagonist haloperidol.

1994 • 116 citations

The nucleus accumbens and learning and memory

1997 • 114 citations

Previous Exposure to Psychostimulants Enhances the Reinstatement of Cocaine Seeking by Nucleus Accumbens AMPA

2004 • 112 citations

Stimuli associated with drug injections as events that control behavior.

1975 • 110 citations

Metabotropic Glutamate Receptors in the Rat Nucleus Accumbens

1997 • 101 citations

Spatial localization in the Morris water maze in rats: Acquisition is affected by intra-accumbens injections of the dopaminergic antagonist haloperidol.

1994 • 92 citations

The novel mGluR2/3 agonist LY379268 attenuates cue-induced reinstatement of heroin seeking

2005 • 90 citations

Amphetamine-Induced Plasticity of AMPA Receptors in the Ventral Tegmental Area: Effects on Extracellular Levels of Dopamine and Glutamate in Freely Moving Rats

2001 • 86 citations

Effects of the AMPA/kainate receptor antagonist DNQX in the nucleus accumbens on drug-induced conditioned place preference

1993 • 79 citations

Activation of group II mGlu receptors blocks the enhanced drug taking induced by previous exposure to amphetamine

2005 • 78 citations

Hippocampal and amygdaloid interactions in the nucleus accumbens

1999 • 70 citations

The effects of nucleus accumbens core and shell lesions on intravenous heroin self-administration and the acquisition of drug-seeking behaviour under a second-order schedule of heroin reinforcement

2000 • 69 citations

Ionotropic Glutamate Receptors in the Ventral Tegmental Area Regulate Cocaine-Seeking Behavior in Rats

2005 • 67 citations

An infusion of bupivacaine into the nucleus accumbens disrupts the acquisition but not the expression of contextual fear conditioning.

1999 • 67 citations

DNQX in the nucleus accumbens inhibits cocaine-induced conditioned place preference

1995 • 65 citations

Neuropsychopharmacology of drug seeking: Insights from studies with second-order schedules of drug reinforcement

2005 • 64 citations

Blockade of ionotropic glutamatergic transmission in the ventral tegmental area reduces heroin reinforcement in rat

2002 • 63 citations

Heroin-Specific Stimuli Reinstate Operant Heroin-Seeking Behavior in Rats After Prolonged Extinction

2000 • 56 citations

Selective action of (−)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268), a group II metabotropic glutamate receptor agonist, on basal and phencyclidine-induced dopamine release in the nucleus accumbens shell

2004 • 55 citations

An infusion of bupivacaine into the nucleus accumbens disrupts the acquisition but not the expression of contextual fear conditioning.

1999 • 54 citations

Neurochemical correlates of relapse to d-amphetamine self-administration by rats induced by stimulation of the ventral subiculum

2003 • 54 citations

The mGlu2/3 receptor agonist LY379268 blocks the expression of locomotor sensitization by amphetamine

2002 • 52 citations

Distribution and abundance of metabotropic glutamate receptor subtype 2 in rat brain revealed by [³H]LY354740 binding in vitro and quantitative radioautography: Correlation with the sites of synthesis, expression, and agonist stimulation of [³⁵S]GTPγs binding

2005 • 52 citations

Involvement of the medial septum in stress‐induced relapse to heroin seeking in rats

2000 • 50 citations

Anatomical and Neurochemical Substrates of Drug Reward Determined by the Conditioned Place Preference Technique

1987 • 31 citations

Different anterograde amnesias of fear after tetrodotoxin inactivation and infusion of the GABA A agonist muscimol

2001 • 18 citations