Obesity exacerbates chemically induced neurodegeneration

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Measurement of protein using bicinchoninic acid

1985 • 17,516 citations

Modification of seizure activity by electrical stimulation: II. Motor seizure

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Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia

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The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension

1989 • 1,560 citations

Aging, energy, and oxidative stress in neurodegenerative diseases

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Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease

1989 • 1,369 citations

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

1985 • 1,236 citations

Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration

2000 • 1,215 citations

Overweight, Obesity, and Health Risk

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The Deadly Quartet

1989 • 789 citations

Circulating Insulin-Like Growth Factor I Mediates Effects of Exercise on the Brain

2000 • 734 citations

Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's disease

1992 • 575 citations

Current Protocols in Toxicology

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Long-lasting depletions of striatal dopamine and loss of dopamine uptake sites following repeated administration of methamphetamine

1980 • 533 citations

Role for Excitatory Amino Acids in Methamphetamine-Induced Nigrostriatal Dopaminergic Toxicity

1989 • 495 citations

Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults

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Neurotoxicity profiles of substituted amphetamines in the C57BL/6J mouse.

1994 • 408 citations

A mechanism for glucocorticoid toxicity in the hippocampus: increased neuronal vulnerability to metabolic insults

1985 • 406 citations

Exercise, Antidepressant Medications, and Enhanced Brain Derived Neurotrophic Factor Expression

1999 • 405 citations

Dietary restriction and 2‐deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease

1999 • 385 citations

Mitochondrial Adaptations to Obesity-Related Oxidant Stress

2000 • 362 citations

Dietary Restriction Benefits Learning and Motor Performance of Aged Mice

1987 • 341 citations

Regulation of Neuronal and Glial Proteins by Leptin: Implications for Brain Development*

1999 • 320 citations

Mitochondrial superoxide production in kainate-induced hippocampal damage

2000 • 301 citations

Dietary lipids and antioxidants in Parkinson's disease: A population‐based, case‐control study

1996 • 295 citations

Role of Dopamine Transporter in Methamphetamine-Induced Neurotoxicity: Evidence from Mice Lacking the Transporter

1998 • 259 citations

Environment-, drug- and stress-induced alterations in body temperature affect the neurotoxicity of substituted amphetamines in the C57BL/6J mouse.

1994 • 254 citations

Influence of methamphetamine on nigral and striatal tyrosine hydroxylase activity and on striatal dopamine levels

1976 • 217 citations

Effects of 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine and 1‐Methyl‐4‐Phenylpyridinium Ion on Activities of the Enzymes in the Electron Transport System in Mouse Brain

1987 • 214 citations

Glucocorticoids Enhance Oxidative Stress-Induced Cell Death in Hippocampal Neuronsin Vitro

1997 • 202 citations

Glucocorticoids may alter antioxidant enzyme capacity in the brain: baseline studies

1998 • 174 citations

Quantification of glial fibrillary acidic protein: Comparison of slot-immunobinding assays with a novel sandwich ELISA

1991 • 152 citations

Parallel increases in lipid and protein oxidative markers in several mouse brain regions after methamphetamine treatment

2001 • 149 citations

Glucocorticoids Regulate the Synthesis of Glial Fibrillary Acidic Protein in Intact and Adrenalectomized Rats but Do Not Affect Its Expression Following Brain Injury

1991 • 125 citations

CNS oxidative stress associated with the kainic acid rodent model of experimental epilepsy

2000 • 125 citations

A single dose model of methamphetamine-induced neurotoxicity in rats: effects on neostriatal monoamines and glial fibrillary acidic protein

1998 • 108 citations

Hypothalamic-pituitary-adrenal system function in patients with alzheimer's disease

1995 • 104 citations

Glucocorticoids regulate the concentration of glial fibrillary acidic protein throughout the brain

1989 • 90 citations

Thiol Oxidation and Loss of Mitochondrial Complex I Precede Excitatory Amino Acid-Mediated Neurodegeneration

1998 • 87 citations

Regulation of Neuronal and Glial Proteins by Leptin: Implications for Brain Development

1999 • 83 citations

Methamphetamine administration causes overexpression of nNOS in the mouse striatum

1999 • 73 citations

Methamphetamine generates peroxynitrite and produces dopaminergic neurotoxicity in mice: protective effects of peroxynitrite decomposition catalyst

1999 • 72 citations

Acute neuropathological changes in the caudate nucleus caused by MPTP and methamphetamine: Immunohistochemical studies

1990 • 71 citations

Quantitative immunochemistry on neuronal loss, reactive gliosis and BBB damage in cortex/striatum and hippocampus/amygdala after systemic kainic acid administration

2000 • 66 citations

Glucocorticoids Enhance Oxidative Stress-Induced Cell Death in Hippocampal Neurons in Vitro

1997 • 65 citations

Antioxidant Vitamin Levels in Plasma and Low Density Lipoprotein of Obese Girls

1998 • 62 citations

Obesity as a risk factor in drug-induced organ injury: increased liver and kidney damage by acetaminophen in the obese overfed rat.

1987 • 56 citations

Neuronal damage and MAP2 changes induced by the glutamate transport inhibitor dihydrokainate and by kainate in rat hippocampus in vivo

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Methamphetamine-induced striatal dopamine neurotoxicity and cyclooxygenase-2 protein expression in BALB/c mice

2000 • 42 citations

Measurement of Glial Fibrillary Acidic Protein

2002 • 38 citations

Kainic acid induces selective mitochondrial oxidative phosphorylation enzyme dysfunction in cerebellar granule neurons: protective effects of melatonin and GSH ethyl ester

2001 • 36 citations

Neurotoxic Effects of Substituted Amphetamines in Rats and Mice: Challenges to the Current Dogma

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Quantitative Immunoblots of Proteins Resolved from Brain Homogenates: Underestimation of Specific Protein Concentration and of Treatment Effects

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Brain deviations in adult obese-hyperglycemic mice (ob/ob)

1979 • 32 citations

Kainate-induced hippocampal DNA damage is attenuated in superoxide dismutase transgenic mice

1997 • 32 citations

The susceptibility of spontaneously diabetic mice cadmium-metallothionein nephrotoxicity

1994 • 31 citations

AP-1 DNA-binding activation by methamphetamine involves oxidative stress

1996 • 26 citations

Regional and temporal profiles of calcium accumulation and glial fibrillary acidic protein levels in rat brain after systemic injection of kainic acid

1994 • 26 citations

Presence of apolipoprotein E immunoreactivity in degenerating neurones of mice is dependent on the severity of kainic acid-induced lesion

2000 • 23 citations

Nitric oxide enhances MPP⁺ inhibition of complex I

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Obesity as a risk factor in drug-induced organ injury

1989 • 19 citations

Mitochondrial energy crisis in Parkinson's disease.

1993 • 16 citations