Obesity as a risk factor in drug-induced organ injury

Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism.

1973 • 1,467 citations

Dietary Obesity in Rats: Body Weight and Body Fat Accretion in Seven Strains of Rats

1970 • 349 citations

Metabolic Activation of Drugs to Toxic Substances

1975 • 281 citations

Predicting creatinine clearance and renal drug clearance in obese patients from estimated fat-free body mass

1988 • 248 citations

Drug Disposition in Obese Humans

1986 • 193 citations

Effects of N-acetylcysteine on acetaminophen covalent binding and hepatic necrosis in mice.

1985 • 165 citations

Liver in obesity.

1985 • 139 citations

Liver morphology in morbid obesity: a literature study.

1984 • 134 citations

Renal and hepatic necrosis after metabolic activation of 2-substituted furans and thiophenes, including furosemide and cephaloridine

1977 • 133 citations

Hepatic necrosis caused by furosemide

1974 • 101 citations

Enzymuria in Gentamicin-Induced Kidney Damage

1975 • 99 citations

Liver function in moderate obesity--study in 534 moderately obese subjects among 4613 male company employees.

1986 • 73 citations

Halothane Biotransformation in Obese and Nonobese Patients

1982 • 66 citations

Anesthetic Biotransformation and Renal Function in Obese Patients during and after Methoxyflurane or Halothane Anesthesia

1975 • 59 citations

Obesity as a risk factor in drug-induced organ injury: increased liver and kidney damage by acetaminophen in the obese overfed rat.

1987 • 56 citations

In vivo determination of body composition by tritium dilution in the rat

1979 • 41 citations

Disposition of enflurane in obese patients.

1980 • 31 citations

Phenobarbital in the genetically obese Zucker rat. II. In vivo and in vitro assessments of microsomal enzyme induction.

1984 • 22 citations

In vitro hepatic drug metabolism and microsomal enzyme induction in genetically obese rats

1980 • 21 citations

Phenobarbital induction and acetaminophen hepatotoxicity: resistance in the obese Zucker rodent.

1987 • 20 citations

Anesthetic Metabolism and Renal Function in Obese and Nonobese Fischer 344 Rats Following Enflurane or Isoflurane Anesthesia

1986 • 18 citations

Prospective Study of Liver Function following Repeat Halothane and Enflurane

1981 • 15 citations

Toxicity following methoxyflurane anaesthesia

1976 • 14 citations

Disposition of Enflurane in Obese Patients

1981 • 14 citations

An overfed rat model that reproduces acetaminophen disposition in obese humans.

1986 • 13 citations

Furosemide toxicity in isolated mouse hepatocyte suspensions

1987 • 11 citations

Pharmacokinetic characteristics of the obese overfed rat.

1989 • 9 citations

Obesity as a risk factor in drug induced organ injury. II. Increased renal cytochrome P-450 in the obese overfed rat.

1988 • 5 citations

Hepatic cytochrome P-450 and in vitro drug metabolism in an overfed rat model of obesity.

1988 • 4 citations

Pharmacokinetic characteristics of the obese overfed rat.

1989 • 2 citations

Deleted Work

1955 • 0 citations