Quantitative immunochemistry on neuronal loss, reactive gliosis and BBB damage in cortex/striatum and hippocampus/amygdala after systemic kainic acid administration

A soluble protein characteristic of the nervous system

1965 • 1,678 citations

Glial fibrillary acidic protein (GFAP): the major protein of glial intermediate filaments in differentiated astrocytes

1985 • 714 citations

Widespread patterns of neuronal damage following systemic or intracerebral injections of kainic acid: A histological study

1980 • 700 citations

Quantitative aspects of reactive gliosis: A review

1992 • 548 citations

Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity

1998 • 538 citations

Kainic acid induced seizures: Neurochemical and histopathological changes

1983 • 526 citations

GFAP Is Necessary for the Integrity of CNS White Matter Architecture and Long-Term Maintenance of Myelination

1996 • 521 citations

Role of glial cells in the regulation of the brain ion microenvironment

1989 • 448 citations

Excitatory amino acids directly depolarize rat brain astrocytes in primary culture

1984 • 358 citations

Glutamate receptor-mediated toxicity in optic nerve oligodendrocytes

1997 • 352 citations

Stimulation of astroglial 5-HT1A receptors releases the serotonergic growth factor, protein S-100, and alters astroglial morphology

1990 • 317 citations

Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein.

1992 • 289 citations

Astrocytes: Form, Functions, and Roles in Disease

1994 • 278 citations

Microglial and Astroglial Reactions to Ischemic and Kainic Acid-Induced Lesions of the Adult Rat Hippocampus

1993 • 266 citations

Astrocyte heterogeneity

1990 • 254 citations

Brain Region and Gene Specificity of Neuropeptide Gene Expression in Cultured Astrocytes

1989 • 219 citations

Neuron-glia interactions.

1979 • 213 citations

The S-100: A protein family in search of a function

1995 • 211 citations

GFAP‐positive hippocampal astrocytes in situ respond to glutamatergic neuroligands with increases in [Ca²⁺]_i

1995 • 201 citations

Immunohistochemical study of glial reaction and serum-protein extravasation in relation to neuronal damage in rat hippocampus after ischemia

1990 • 185 citations

Fluorescence measurement of changes in intracellular calcium induced by excitatory amino acids in cultured cortical astrocytes

1990 • 174 citations

Neuron-glia interactions.

1979 • 168 citations

Impaired induction of blood-brain barrier properties in aortic endothelial cells by astrocytes from GFAP-deficient mice.

1998 • 137 citations

Immunohistochemical co-localization of S-100b and the glial fibrillary acidic protein in rat brain

1986 • 136 citations

Immunocytochemical evidence for a distinct GFAP-negative subpopulation of astrocytes in the adult rat hippocampus

1998 • 135 citations

The role of brain edema in epileptic brain damage induced by systemic kainic acid injection

1984 • 134 citations

Biochemical and immunocytochemical changes in glial fibrillary acidic protein after sab wounds

1990 • 126 citations

Pharmacological characterization of the glutamate receptor in cultured astrocytes

1989 • 123 citations

Regional Heterogeneity in the Response of Astrocytes following Traumatic Brain Injury in the Adult Rat

1996 • 116 citations

Neurotrophic activity of S-100β in cultures of dorsal root ganglia from embryonic chick and fetal rat

1991 • 114 citations

S-100 protein, but not calmodulin, binds to the glial fibrillary acidic protein and inhibits its polymerization in a Ca(2+)-dependent manner

1993 • 113 citations

Impaired induction of blood-brain barrier properties in aortic endothelial cells by astrocytes from GFAB-deficient mice

1998 • 108 citations

Morphological and Immunophenotypic Microglial Changes in the Denervated Fascia Dentata of Adult Rats: Correlation with Blood–Brain Barrier Damage and Astroglial Reactions

1997 • 106 citations

Blood-brain barrier changes with kainic acid-induced limbic seizures

1983 • 93 citations

Neuron-specific enolase as a marker of neuronal lesions during various comas in man☆

1982 • 92 citations

S-100β stimulates neurite outgrowth in the rat sciatic nerve grafted with acellular muscle transplants

1997 • 92 citations

Glutamate receptor‐linked changes in membrane potential and intracellular Ca²⁺ in primary rat astrocytes

1989 • 90 citations

S-100β has a neuronal localisation in the rat hindbrain revealed by an antigen retrieval method

1995 • 79 citations

Reaction of astrocytes in the gerbil hippocampus following transient ischemia: Immunohistochemical observations with antibodies against glial fibrillary acidic protein, glutamine synthetase, and S-100 protein

1992 • 74 citations

Calcium-mediated breakdown of glial filaments and neurofilaments in rat optic nerve and spinal cord

1981 • 72 citations

Demyelination, and remyelination by Schwann cells and oligodendrocytes after kainate-induced neuronal depletion in the central nervous system

1992 • 68 citations

GFAP and S100β Expression in the Cortex and Hippocampus in Response to Mild Cortical Contusion

1997 • 68 citations

Interneurons versus efferent neurons: Heterogeneity in their neurite outgrowth response to glia from several brain regions

1988 • 56 citations

Qualitative analysis of membrane currents in glial cells from normal and gliotic tissue in situ: down-regulation of Na+ current and lack of P2 purinergic responses

1997 • 55 citations

Extracellular potassium influences DNA and protein syntheses and glial fibrillary acidic protein expression in cultured glial cells

1990 • 55 citations

Induction of cortical spreading depression with potassium chloride upregulates levels of messenger RNA for glial fibrillary acidic protein in cortex and hippocampus: inhibition by MK-801

1993 • 54 citations

Hippocampal kindling alters the concentration of glial fibrillary acidic protein and other marker proteins in rat brain

1990 • 52 citations

S100β prevents the death of motor neurons in newborn rats after sciatic nerve section

1997 • 51 citations

Gliotoxic actions of excitatory amino acids

1992 • 48 citations

Neurite extension factor induces rapid morphological differentiation of mouse neuroblastoma cells in defined medium

1987 • 47 citations

GLIAL FIBRILLARY ACIDIC PROTEIN: A REVIEW OF STRUCTURE, FUNCTION, AND CLINICAL APPLICATION

1988 • 46 citations

Neuronal and Glial Proteins: Structure, Function, and Clinical Application

1988 • 46 citations

Metabotropic Glutamate Receptor Activation Modulates Kainate and Serotonin Calcium Response in Astrocytes

1997 • 42 citations

S100 immunoreactivity in a subpopulation of oligodendrocytes and Ranvier's nodes of adult rat brain

1995 • 42 citations

Intermediate filaments in astrocytes

1999 • 42 citations

Blood-brain barrier dysfunctions following systemic injection of kainic acid in the rat

1992 • 40 citations

Damage of substantia nigra pars reticulata during pilocarpine-induced status epilepticus in the rat: immunohistochemical study of neurons, astrocytes and serum-protein extravasation

1991 • 36 citations

Changes in Neurofilament Protein NF‐L and NF‐H Immunoreactivity Following Kainic Acid‐Induced Seizures

1994 • 35 citations

The effect of anN-methyl-d-aspartate lesion in the hippocampus on glial and neuronal marker proteins

1991 • 34 citations

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)- induced damage of striatal dopaminergic fibers attenuates subsequent astrocyte response to MPTP

1990 • 31 citations

Expression of glial fibrillary acidic protein by differentiated astrocytes is regulated by serum antagonistic factors

1988 • 30 citations

A morphological study on glutamate-induced swelling of cultured astrocytes: Involvement of calcium and chloride ion mechanisms

1991 • 30 citations

Regional and temporal profiles of calcium accumulation and glial fibrillary acidic protein levels in rat brain after systemic injection of kainic acid

1994 • 26 citations

A simple quantitative dot-immunobinding assay for glial and neuronal marker proteins in SDS-solubilized brain tissue extracts

1990 • 25 citations

Mechanisms Underlying Glutamate-induced Swelling of Astrocytes in Primary Culture

1990 • 21 citations

Neuron-Glia Interrelations During Phylogeny

1995 • 19 citations

Presence of S-100β in cholinergic neurones of the rat hindbrain

1996 • 8 citations

Extravasated Protein as a Cause of Limbic Seizure-Induced Brain Damage: An Evaluation Using Kainic Acid

1986 • 7 citations

Neuronal and Glial Marker Proteins in the Evaluation of the Protective Action of MK 801

1991 • 6 citations

Behavioral and biochemical effects of intraventricular kainic acid.

1980 • 5 citations