Trans receptor inhibition of human glioblastoma cells by erbB family ectodomains

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

1989 • 3,477 citations

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

Dimerization of cell surface receptors in signal transduction

1995 • 1,631 citations

Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin

1985 • 1,523 citations

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

The neu oncogene encodes an epidermal growth factor receptor-related protein

1986 • 1,131 citations

A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity.

1994 • 932 citations

Structural alterations of the epidermal growth factor receptor gene in human gliomas.

1992 • 853 citations

Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification.

1987 • 843 citations

Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops.

1992 • 689 citations

ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer.

1996 • 675 citations

Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin.

1987 • 648 citations

Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails.

1992 • 609 citations

A neu acquaintance for ErbB3 and ErbB4: A role for receptor heterodimerization in growth signaling

1994 • 601 citations

Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas.

1990 • 593 citations

Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology.

1993 • 534 citations

Clonal genomic alterations in glioma malignancy stages.

1988 • 520 citations

A point mutation in the neu oncogene mimics ligand induction of receptor aggregation

1989 • 432 citations

Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma.

1990 • 384 citations

Intermolecular association of the p185 protein and EGF receptor modulates EGF receptor function

1990 • 362 citations

Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts

1989 • 316 citations

Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: a mechanism for receptor transregulation

1990 • 246 citations

A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization.

1991 • 227 citations

Amplification of the epidermal‐growth‐factor‐receptor gene correlates with different growth behaviour in human glioblastoma

1994 • 204 citations

Differential expression of platelet-derived growth factor receptors in human malignant glioma cell lines.

1991 • 181 citations

Identification and Structural Analysis of the A Type Receptor for Platelet-derived Growth Factor

1989 • 179 citations

Lack of p16INK4 or retinoblastoma protein (pRb), or amplification-associated overexpression of cdk4 is observed in distinct subsets of malignant glial tumors and cell lines.

1995 • 166 citations

A Deletion Mutation within the Ligand Binding Domain Is Responsible for Activation of Epidermal Growth Factor Receptor Gene in Human Brain Tumors

1990 • 158 citations

Heterodimerization of epidermal growth factor receptorand wild-type or kinase-deficient Neu: a mechanism of interreceptor kinaseactivation and transphosphorylation.

1994 • 157 citations

BCL2-mediated tumorigenicity of a human T-lymphoid cell line: synergy with MYC and inhibition by BCL2 antisense.

1990 • 157 citations

Selective amplification of the cytoplasmic domain of the epidermal growth factor receptor gene in glioblastoma multiforme.

1988 • 157 citations

Evidence for epidermal growth factor (EGF)-induced intermolecular autophosphorylation of the EGF receptors in living cells.

1990 • 132 citations

Constitutive phosphorylation of Shc proteins in human tumors.

1995 • 130 citations

Inhibition of glioma cell growth by a truncated platelet-derived growth factor-beta receptor.

1994 • 116 citations

Epidermal growth factor (EGF) induces oligomerization of soluble, extracellular, ligand-binding domain of EGF receptor. A low resolution projection structure of the ligand-binding domain

1991 • 105 citations

Heterodimerization of c-erbB2 with different epidermal growth factor receptor mutants elicits stimulatory or inhibitory responses.

1992 • 104 citations

Heterogeneous response to the growth factors [EGF, PDGF (bb), TGF‐α, bFGF, IL‐2] on glioma spheroid growth, migration and invasion

1994 • 84 citations

Interaction of the neu/p185 and EGF receptor tyrosine kinases: Implications for cellular transformation and tumor therapy

1993 • 79 citations

p185c-neu and epidermal growth factor receptor associate into a structure composed of activated kinases.

1992 • 78 citations

Kinase-deficient neu proteins suppress epidermal growth factor receptor function and abolish cell transformation.

1994 • 68 citations

Inhibition of Thyrotropin-Stimulated DNA Synthesis by Microinjection of Inhibitors of Cellular Ras and Cyclic AMP-Dependent Protein Kinase

1993 • 67 citations

Accumulation of genetic defects during astrocytoma progression

1992 • 60 citations

Altered subcellular location of an activated and tumour-associated epidermal growth factor receptor.

1995 • 53 citations

Analysis of mammalian fibroblast transformation by normal and mutated human EGF receptors.

1989 • 53 citations

Tissue-Specific Transformation by Oncogenic Mutants of Epidermal Growth Factor Receptor

1994 • 41 citations

A complete description of the EGF-receptor exon structure: implication in oncogenic activation and domain evolution.

1993 • 39 citations

Intermolecular association and trans-phosphorylation of different neu-kinase forms permit SH2-dependent signaling and oncogenic transformation.

1995 • 33 citations

Cell cycle-dependent regulation of p185neu: a relationship between disruption of this regulation and transformation.

1995 • 23 citations

Association of Signaling Proteins with a Nonmitogenic Heterodimeric Complex Composed of Epidermal Growth Factor Receptor and Kinase-Inactive p185^c-neu"

1996 • 11 citations