Protein phosphorylation in isolated trabeculae from nonfailing and failing human hearts

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts

1982 • 2,259 citations

Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure.

1987 • 923 citations

Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation.

1994 • 696 citations

Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure.

1992 • 656 citations

Deficient production of cyclic AMP: pharmacologic evidence of an important cause of contractile dysfunction in patients with end-stage heart failure.

1987 • 500 citations

Phosphorylation of the Sarcoplasmic Reticulum and Sarcolemma

1982 • 441 citations

Regulation of Transforming Growth Factor-β Activation by Discrete Sequences of Thrombospondin 1

1995 • 413 citations

Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation.

1994 • 407 citations

Unchanged Protein Levels of SERCA II and Phospholamban but Reduced Ca ²⁺ Uptake and Ca ²⁺ -ATPase Activity of Cardiac Sarcoplasmic Reticulum From Dilated Cardiomyopathy Patients Compared With Patients With Nonfailing Hearts

1995 • 384 citations

INCREASE IN MYOCARDIAL Gi-PROTEINS IN HEART FAILURE

1988 • 315 citations

Cardiac Troponin I Phosphorylation Increases the Rate of Cardiac Muscle Relaxation

1995 • 314 citations

Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart.

1994 • 300 citations

Purification and complete sequence determination of the major plasma membrane substrate for cAMP-dependent protein kinase and protein kinase C in myocardium

1991 • 257 citations

Troponin I gene expression during human cardiac development and in end-stage heart failure.

1993 • 242 citations

Ca(2+)-transporting ATPase, phospholamban, and calsequestrin levels in nonfailing and failing human myocardium.

1994 • 228 citations

Abnormalities of diastolic function as a potential cause of exercise intolerance in chronic heart failure.

1990 • 206 citations

Alterations in Ca2+ sensitive tension due to partial extraction of C-protein from rat skinned cardiac myocytes and rabbit skeletal muscle fibers.

1991 • 192 citations

cAMP concentrations, cAMP dependent protein kinase activity, and phospholamban in non-failing and failing myocardium

1994 • 134 citations

Phosphorylation of the L‐type calcium channel β subunit is involved in β‐adrenergic signal transduction in canine myocardium

1993 • 111 citations

Basal and Isoprenaline-Stimulated cAMP Content in Failing Versus Nonfailing Human Cardiac Preparations

1989 • 99 citations

Titin, Myosin Light Chains and C-Protein in the Developing and Failing Human Heart

1994 • 92 citations

Differential sensitivity to isoprenaline of troponin I and phospholamban phosphorylation in isolated rat hearts

1990 • 89 citations

Altered expression of α-subunits of G proteins in failing human hearts

1989 • 80 citations

Phospholamban-mediated stimulation of Ca2+ uptake in sarcoplasmic reticulum from normal and failing hearts.

1990 • 80 citations

Phosphorylation of Ryanodine Receptors in Rat Myocytes during β-Adrenergic Stimulation

1992 • 79 citations

Identification of Soluble Protein Phosphatases That Dephosphorylate Voltage-sensitive Sodium Channels in Rat Brain

1995 • 73 citations

Reduced positive inotropic effects in diseased human ventricular myocardium

1986 • 61 citations

Mechanism underlying the reduced positive inotropic effects of the phosphodiesterase III inhibitors pimobendan, adibendan and saterinone in failing as compared to nonfailing human cardiac muscle preparations

1991 • 55 citations

Distribution of beta-adrenergic receptors in failing human myocardium. Implications for mechanisms of down-regulation.

1989 • 54 citations

Effects of α- and β-adrenergic agonists, phosphodiesterase inhibitors and adenosine on isolated human heart muscle preparations

1987 • 53 citations