Mechanism underlying the reduced positive inotropic effects of the phosphodiesterase III inhibitors pimobendan, adibendan and saterinone in failing as compared to nonfailing human cardiac muscle preparations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts

1982 • 2,259 citations

Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure.

1986 • 1,297 citations

Multiple cyclic nucleotide phosphodiesterase activities from rat brain

1971 • 1,054 citations

Plasma norepinephrine in congestive heart failure

1978 • 919 citations

Activity of the sympathetic nervous system and renin-angiotensin system assessed by plasma hormone levels and their relation to hemodynamic abnormalities in congestive heart failure

1982 • 617 citations

Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart.

1988 • 545 citations

Neurohormonal interactions and adaptations in congestive heart failure.

1988 • 540 citations

Deficient production of cyclic AMP: pharmacologic evidence of an important cause of contractile dysfunction in patients with end-stage heart failure.

1987 • 500 citations

Heart Failure in Outpatients

1982 • 452 citations

New Positive Inotropic Agents in the Treatment of Congestive Heart Failure

1986 • 402 citations

Increase of Gi alpha in human hearts with dilated but not ischemic cardiomyopathy.

1990 • 324 citations

INCREASE IN MYOCARDIAL Gi-PROTEINS IN HEART FAILURE

1988 • 315 citations

The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors

1987 • 303 citations

Multiple molecular forms of cyclic nucleotide phosphodiesterase in cardiac and smooth muscle and in platelets

1986 • 249 citations

Assay of cyclic nucleotide phosphodiesterase and resolution of multiple molecular forms of the enzyme.

1979 • 244 citations

Subclasses of cyclic AMP-specific phosphodiesterase in left ventricular muscle and their involvement in regulating myocardial contractility.

1987 • 218 citations

Reduction of beta-adrenoceptor density and evaluation of positive inotropic responses in isolated, diseased human myocardium

1988 • 200 citations

Forskolin, adenylate cyclase, and cell physiology: an overview.

1984 • 181 citations

Additive effects of dobutamine and amrinone on myocardial contractility and ventricular performance in patients with severe heart failure.

1986 • 172 citations

Study of the normal and failing isolated human heart: Decreased response of failing heart to isoproterenol

1983 • 172 citations

Inotropic drugs and their mechanisms of action

1984 • 151 citations

Pharmacology and inotropic potential of forskolin in the human heart.

1984 • 131 citations

Vasodilator and inotropic drugs for the treatment of chronic heart failure: Distinguishing hype from hope

1988 • 113 citations

Adenosine inhibition of catecholamine-induced increase in force of contraction in guinea-pig atrial and ventricular heart preparations. Evidence against a cyclic AMP- and cyclic GMP-dependent effect.

1984 • 109 citations

Relation of positive inotropic and chronotropic effects of pimobendan, UD-CG 212 Cl, milrinone and other phosphodiesterase inhibitors to phosphodiesterase III inhibition in guinea-pig heart

1989 • 104 citations

Basal and Isoprenaline-Stimulated cAMP Content in Failing Versus Nonfailing Human Cardiac Preparations

1989 • 99 citations

An improved assay of cyclic 3?,5?-nucleotide phosphodiesterases with QAE-Sephadex columns

1980 • 88 citations

UD-CG 115 ? a cardiotonic pyridazinone which elevates cyclic AMP and prolongs the action potential in guinea-pig papillary muscle

1984 • 74 citations

Inotropic and vasodilator effects of amrinone on isolated human tissue

1984 • 66 citations

Effects of α- and β-adrenergic agonists, phosphodiesterase inhibitors and adenosine on isolated human heart muscle preparations

1987 • 53 citations

Mechanism of action and cardiotonic activity of a new phosphodiesterase inhibitor, the benzimidazole derivative adibendan (BM 14.478), in guinea-pig hearts

1988 • 36 citations

Effects of the benzimidazole derivatives pimobendan and 2-(4-hydroxy-phenyl)-5-(5-methyl-3-oxo-4,5-dihydro-2H-6- pyridazinyl) benzimidazole . HCl on phosphodiesterase activity and force of contraction in guinea-pig hearts.

1985 • 36 citations

Effects of Chronic Heart Failure on the Capacity of Glucagon to Enhance Contractility and Adenyl Cyclase Activity of Human Papillary Muscles

1971 • 35 citations

The effectiveness of inotropic agents in isolated cardiac preparations from the human heart

1988 • 33 citations

Cardiovascular effects of the positive inotropic agents pimobendan and sulmazole in vivo.

1985 • 33 citations

The role of cyclic AMP in the positive inotropic effect mediated by ?1- and ?2-adrenoceptors in isolated human right atrium

1987 • 32 citations

Pimobendane (UD-CG115 BS) in Chronic Congestive Heart Failure

1988 • 31 citations

Selective inhibition of cyclic AMP phosphodiesterase from various human tissues by milrinone, a potent cardiac bipyridine

1988 • 30 citations

Enhancement of the effectiveness of milrinone to increase force of contraction by stimulation of cardiac beta-adrenoceptors in the failing human heart

1988 • 28 citations

Observations on the intracoronary administration of milrinone and dobutamine to patients with congestive heart failure

1989 • 17 citations

Selective inhibition of cAMP phosphodiesterase III activity by the cardiotonic agent saterinone in guinea pig myocardium.

1988 • 11 citations

Hemodynamic Profile of BM 14.478: A New Positive Inotropic and Vasodilating Agent

1988 • 10 citations

Acute and Long-Term Hemodynamic Effects of Pimobendan (UD-CG 115 BS) in Comparison with Captopril

1989 • 10 citations

Positive inotropic and vasodilatory actions of saterinone in vivo.

1988 • 4 citations