Selective opioid receptor agonists modulate mechanical allodynia in an animal model of neuropathic pain

Ethical guidelines for investigations of experimental pain in conscious animals

1983 • 7,639 citations

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

1988 • 5,129 citations

Mortality and Morbidity in Patients Receiving Encainide, Flecainide, or Placebo

1991 • 3,106 citations

Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain

1988 • 996 citations

Naltrindole, a highly selective and potent non-peptide δ opioid receptor antagonist

1988 • 599 citations

The nature of opioid responsiveness and its implications for neuropathic pain: new hypotheses derived from studies of opioid infusions

1990 • 574 citations

Antidepressant-induced analgesia in chronic non-malignant pain: a meta-analysis of 39 placebo-controlled studies

1992 • 562 citations

Peripheral opioid receptors mediating antinociception in inflammation. Evidence for involvement of mu, delta and kappa receptors.

1989 • 520 citations

Further evidence for ‘pain-related’ behaviours in a model of unilateral peripheral mononeuropathy

1990 • 504 citations

Both intravenous lidocaine and morphine reduce the pain of postherpetic neuralgia

1991 • 494 citations

Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction

1992 • 452 citations

The pharmacological basis of therapeutics

1966 • 412 citations

κ-Opioid receptors and analgesia

1990 • 318 citations

Efficacy of desipramine in painful diabetic neuropathy: a placebo-controlled trial

1991 • 302 citations

The Use of Antidepressants in the Treatment of Chronic Pain

1991 • 251 citations

Prolonged relief of neuralgia after regional anesthetic blocks. A call for further experimental and systematic clinical studies

1990 • 250 citations

Psychophysical observations on patients with neuropathic pain relieved by a sympathetic block

1989 • 249 citations

Antinociceptive effects of μ- and κ-agonists in inflammation are enhanced by a peripheral opioid receptor-specific mechanism

1988 • 215 citations

Morphine differentially affects the sensory and affective pain ratings in neurogenic and idiopathic forms of pain

1991 • 209 citations

Morphine responsiveness of chronic pain: double-blind randomised crossover study with patient-controlled analgesia

1992 • 202 citations

Anticonvulsant Drugs and Chronic Pain

1984 • 195 citations

The Use of Oral Mexiletine for the Treatment of Pain after Peripheral Nerve Injury

1992 • 189 citations

Dynorphin increases in the dorsal spinal cord in rats with a painful peripheral neuropathy

1990 • 187 citations

Analgesic effects of kelatorphan, a new highly potent inhibitor of multiple enkephalin degrading enzymes

1984 • 168 citations

Up-regulation of opioid gene expression in spinal cord evoked by experimental nerve injuries and inflammation

1991 • 161 citations

The analgesic effects of morphine, but not those of the enkephalinase inhibitor thiorphan, are enhanced in arthritic rats

1983 • 155 citations

Mechanisms of the analgesic actions of opiates and opioids

1991 • 148 citations

Attempts to gauge the relative importance of pre- and postsynaptic effects of morphine on the transmission of noxious messages in the dorsal horn of the rat spinal cord

1989 • 127 citations

Neurochemical and Anatomical Changes in the Dorsal Horn of Rats with an Experimental Painful Peripheral Neuropathy

1989 • 114 citations

Regulation of opioid binding sites in the superficial dorsal horn of the rat spinal cord following loose ligation of the sciatic nerve: Comparison with sciatic nerve section and lumbar dorsal rhizotomy

1992 • 109 citations

Bilateral and differential changes in spinal mu, delta and kappa opioid binding in rats with a painful, unilateral neuropathy

1991 • 108 citations

Multiplicative interaction between intrathecally and intracerebroventricularly administered mu opioid agonists but limited interactions between delta and kappa agonists for antinociception in mice.

1989 • 103 citations

Potent antinociceptive effects of Kelatorphan (a highly efficient inhibitor of multiple enkephalin-degrading enzymes) systemically administered in normal and arthritic rats

1989 • 100 citations

Neuropathic pain and injured nerve: Central mechanisms

1991 • 99 citations

Differential effects of various doses of morphine and naloxone on two nociceptive test thresholds in arthritic and normal rats

1990 • 92 citations

Deafferentation Pain Syndromes: Pathophysiology and Treatment

1991 • 86 citations

Behavioural evidence that systemic morphine may modulate a phasic pain-related behaviour in a rat model of peripheral mononeuropathy

1991 • 82 citations

Kappa-opioid receptor-mediated antinociception in the rat. II. Supraspinal in addition to spinal sites of action.

1989 • 75 citations

Opioid receptor types and antinociceptive activity in chronic inflammation: bothe κ- and μ-opiate agonistic effects are enhanced in arthritic rats

1986 • 72 citations

Pain complaint and the weather: weather sensitivity and symptom complaints in chronic pain patients

1992 • 66 citations

Development of conformationally constrained linear peptides exhibiting a high affinity and pronounced selectivity for .delta. opioid receptors

1988 • 62 citations

III - Prostaglandin hyperalgesia: Relevance of the peripheral effect for the analgesic action of opioid-antagonists

1979 • 61 citations

Can opiates relieve neuropathic pain?

1988 • 58 citations

Behavioural evidence for a bidirectional effect of systemic naloxone in a model of experimental neuropathy in the rat

1989 • 53 citations

Repeated low doses of morphine do not induce tolerance but increase the opioid antinociceptive effect in rats with a peripheral neuropathy

1990 • 49 citations

Antinociceptive and motor effects of delta/mu and kappa/mu combinations of intrathecal opioid agonists

1992 • 49 citations

κ- and δ-opioid agonists synergize to produce potent analgesia

1990 • 48 citations

The ‘tonic’ pain-related behaviour seen in mononeuropathic rats is modulated by morphine and naloxone

1991 • 46 citations

Behavioural evidence for a peripheral component in the enhanced antinociceptive effect of a low dose of systemic morphine in carrageenin-induced hyperalgesic rats

1991 • 42 citations

Contribution of supraspinal μ- and δ-opioid receptors to antinociception in the rat

1991 • 30 citations

Brain passage of BUBU, a highly selective and potent agonist for δ opioid receptors: In vivo binding and μ versus δ receptors occupancy

1991 • 19 citations

The highly selective δ agonist BUBU induces an analgesic effect in normal and arthritic rat and this action is not affected by repeated administration of low doses of morphine

1993 • 16 citations

Electrophysiological evidence that morphine can exert an antinociceptive effect in a neuropathic state: a study in the ventrobasal thalamus of rats after moderate ligation of one sciatic nerve

1991 • 8 citations