Attempts to gauge the relative importance of pre- and postsynaptic effects of morphine on the transmission of noxious messages in the dorsal horn of the rat spinal cord

Ethical guidelines for investigations of experimental pain in conscious animals

1983 • 7,639 citations

Peripheral and spinal mechanisms of nociception.

1987 • 1,025 citations

Lack of analgesic effect of opioids on neuropathic and idiopathic forms of pain

1988 • 996 citations

Opiate analgesics inhibit substance P release from rat trigeminal nucleus

1977 • 968 citations

Opiate receptor binding in primate spinal cord: distribution and changes after dorsal root section

1976 • 642 citations

Multiple opiate receptor sites on primary afferent fibres

1980 • 621 citations

Enkephalin inhibits release of substance P from sensory neurons in culture and decreases action potential duration.

1979 • 546 citations

Electrophysiology of opioids.

1983 • 377 citations

Nociceptive action of excitatory amino acids in the mouse: effects of spinally administered opioids, phencyclidine and sigma agonists.

1987 • 373 citations

The mechanism of inhibition of neuronal activity by opiates in the spinal cord of cat

1976 • 321 citations

Substantia gelatinosa neurones hyperpolarized in vitro by enkephalin

1983 • 236 citations

The electron microscopic localization of methionine-enkephalin within the superficial layers (I and II) of the spinal cord

1980 • 234 citations

Some Effects of Deafferentation on Neurons of the Cat Spinal Cord

1967 • 231 citations

Depressive effects of morphine upon lamina V cells activities in the dorsal horn of the spinal cat

1975 • 198 citations

Pharmacological characterization of substance P-induced nociception in mice: modulation by opioid and noradrenergic agonists at the spinal level.

1983 • 193 citations

The effects of methionine- and leucine-enkephalin on spinal neurones of the cat

1979 • 184 citations

Deafferentation hypersensitivity in the rat after dorsal rhizotomy: A possible animal model of chronic pain

1979 • 176 citations

Specific-Opiate-Induced Depression of Transmitter Release from Dorsal Root Ganglion Cells in Culture

1978 • 163 citations

The actions of neuropeptides on dorsal horn neurons in the rat spinal cord slice preparation: an intracellular study

1982 • 159 citations

Parallel clinical and behavioural studies of adjuvant-induced arthritis in the rat: Possible relationship with ‘chronic pain’

1987 • 157 citations

Electrophysiological characteristics of dorsal horn cells in rats with cutaneous inflammation resulting from chronic arthritis

1982 • 156 citations

Ultrastructural localization and biochemical features of immunoreactive LEU-enkephalin in monkey dorsal horn

1981 • 154 citations

A new method for the evaluation of analgesic activity using adjuvant-induced arthritis in the rat

1975 • 150 citations

Effect of dorsal rhizotomy on the autoradiographic distribution of opiate and neurotensin receptors and neurotensin-like immunoreactivity within the rat spinal cord

1981 • 150 citations

Effects of Morphine and Naloxone on Dorsal Horn Neurones in the Cat

1974 • 143 citations

Deafferentation in animals as a model for the study of pain: an alternative hypothesis

1984 • 143 citations

Indirect evidence for presynaptic location of opiate receptors on chemosensitive primary sensory neurones

1979 • 134 citations

Opiates and Pain Pathways: Demonstration of Enkephalin Synapses on Dorsal Horn Projection Neurons

1982 • 121 citations

Sensory receptors in ankle joint capsules of normal and arthritic rats

1985 • 115 citations

Demonstration of postsynaptic opioid modulation of thalamic projection neurons by the combined techniques of retrograde horseradish peroxidase and enkephalin immunocytochemistry

1984 • 98 citations

Animal models of chronic pain: Their possible validation from human experience with posterior rhizotomy and congenital analgesia (Part I of the Second John J. Bonica Lecture)

1981 • 87 citations

Differential excitatory and inhibitory effects of opiates on non-nociceptive and nociceptive neurones in the spinal cord of the cat

1978 • 81 citations

The arthritic rat as a model of clinical pain?

1990 • 79 citations

Autoradiographic study of μ and δ opioid binding sites and neutral endopeptidase-24.11 in rat after dorsal root rhizotomy

1989 • 77 citations

Use of Freund's adjuvant arthritis test in anti-flammatory drug screening in the rat: value of animal selection and preparation at the breeding center.

1976 • 72 citations

Actions of opioids on primate spinothalamic tract neurons

1986 • 72 citations

Electrophysiological study of cervical dorsal horn cells in partially deafferented rats

1981 • 66 citations

Mesure de la vitesse de renouvellement du lactate chez le rat par perfusion de 14-C-U (l) lactate

1972 • 63 citations

Presynaptic effects of morphine and methionine-enkephalin in feline spinal cord

1979 • 61 citations

Multiple membrane actions of enkephalin revealed using cultured spinal neurons

1978 • 52 citations

Pain and Society

1985 • 50 citations

Morphine depresses dorsal horn neuron responses to controlled noxious and non-noxious cutaneous stimulation.

1980 • 42 citations

Potent and long lasting antinociceptive effects after injection of low doses of a mu-opioid receptor agonist, fentanyl, into the brachial plexus sheath of the rat

1990 • 40 citations

Functional Response of Multiple Opioid Systems to Chronic Arthritic Pain in the Rat^a

1986 • 20 citations

Peptide receptor functions on cultured spinal neurons.

1980 • 7 citations