Behavioural evidence for a peripheral component in the enhanced antinociceptive effect of a low dose of systemic morphine in carrageenin-induced hyperalgesic rats

Ethical guidelines for investigations of experimental pain in conscious animals

1983 • 7,639 citations

Peripheral opioid receptors mediating antinociception in inflammation. Evidence for involvement of mu, delta and kappa receptors.

1989 • 520 citations

Proceedings of the Vth World Congress on Pain

1988 • 349 citations

II - Prostaglandin hyperalgesia: The peripheral analgesic activity of morphine, enkephalins and opioid antagonists

1979 • 317 citations

Opioid analgesia at peripheral sites: a target for opioids released during stress and inflammation?

1987 • 228 citations

Antinociceptive effects of μ- and κ-agonists in inflammation are enhanced by a peripheral opioid receptor-specific mechanism

1988 • 215 citations

Opioid Analgesia at Peripheral Sites

1987 • 189 citations

Local and remote modifications of nociceptive sensitivity during carrageenin-induced inflammation in the rat

1987 • 179 citations

The analgesic effects of morphine, but not those of the enkephalinase inhibitor thiorphan, are enhanced in arthritic rats

1983 • 155 citations

Dose-dependent analgesic and hyperalgesic effects of systemic naloxone in arthritic rats

1981 • 149 citations

Opiates suppress carrageenan-induced edema and hyperthermia at doses that inhibit hyperalgesia

1990 • 148 citations

Peripheral effect of fentanyl upon nociception in inflamed tissue of the rat

1988 • 130 citations

Reaction thresholds to pressure in edematous hindpaws of rats and responses to analgesic drugs.

1965 • 126 citations

Potent antinociceptive effects of Kelatorphan (a highly efficient inhibitor of multiple enkephalin-degrading enzymes) systemically administered in normal and arthritic rats

1989 • 100 citations

Differential effects of various doses of morphine and naloxone on two nociceptive test thresholds in arthritic and normal rats

1990 • 92 citations

Opioid receptor types and antinociceptive activity in chronic inflammation: bothe κ- and μ-opiate agonistic effects are enhanced in arthritic rats

1986 • 72 citations

III - Prostaglandin hyperalgesia: Relevance of the peripheral effect for the analgesic action of opioid-antagonists

1979 • 61 citations

Local inhibition of inflammatory pain by naloxone and its N-methyl quarternary analogue

1983 • 60 citations

Behavioural evidence for a bidirectional effect of systemic naloxone in a model of experimental neuropathy in the rat

1989 • 53 citations

Chapter 21 Paradoxical effects of low doses of naloxone in experimental models of inflammatory pain

1988 • 42 citations

Potent and long lasting antinociceptive effects after injection of low doses of a mu-opioid receptor agonist, fentanyl, into the brachial plexus sheath of the rat

1990 • 40 citations

Behavioural and electrophysiological studies on the paradoxical antinociceptive effects of an extremely low dose of naloxone in an animal model of acute and localized inflammation

1988 • 29 citations

The bidirectional dose-dependent effect of systemic naloxone is also related to the intensity and duration of pain-related disorders: a study in a rat model of peripheral mononeuropathy

1990 • 27 citations