Soluble c-erbB-2 fragment in serum correlates with disease stage and predicts for shortened survival in patients with early-stage and advanced breast cancer

Neu-Protein Overexpression in Breast Cancer

1988 • 860 citations

Prognostic importance of c-erbB-2 expression in breast cancer. International (Ludwig) Breast Cancer Study Group.

1992 • 855 citations

Expression of c-erbB-2 oncoprotein: a prognostic indicator in human breast cancer.

1989 • 592 citations

The Soluble Interleukin-2 Receptor: Biology, Function, and Clinical Application

1990 • 590 citations

HER-2/neu oncogene protein and prognosis in breast cancer.

1989 • 579 citations

HER-2/neu in node-negative breast cancer: prognostic significance of overexpression influenced by the presence of in situ carcinoma.

1992 • 466 citations

HER-2/neu amplification predicts poor survival in node-positive breast cancer.

1990 • 456 citations

Prognostic significance of HER-2 oncoprotein expression in breast cancer: a 30-year follow-up.

1992 • 318 citations

Follow-up study of HER-2/neu amplification in primary breast cancer.

1991 • 268 citations

Correlation between c-erbB-2 amplification and risk of recurrent disease in node-negative breast cancer.

1991 • 267 citations

Proto-oncogene abnormalities in human breast cancer: correlations with anatomic features and clinical course of disease.

1987 • 143 citations

Elevated soluble c-erbB-2 antigen levels in the serum and effusions of a proportion of breast cancer patients.

1992 • 135 citations

Proto-oncogene abnormalities in human breast cancer: c-ERBB-2 amplification does not correlate with recurrence of disease.

1989 • 127 citations

The neu (c-erbB-2) oncogene.

1989 • 120 citations

In vitro and in vivo Release of Soluble erbB‐2 Protein from Human Carcinoma Cells

1990 • 94 citations

An antigen immunologically related to the external domain of gp185 is shed from nude mouse tumors overexpressing the c-erbB-2 (HER-2/neu) oncogene.

1991 • 74 citations

Antibody‐induced growth inhibition is mediated through immunochemically and functionally distinct epitopes on the extracellular domain of the c‐erbb‐2 (her‐2/neu) gene product p185

1993 • 65 citations

c-erbB-2 positive breast tumours behave more aggressively in the first years after diagnosis

1992 • 28 citations

PPACK-thrombin inhibits thrombin-induced platelet aggregation and cytoplasmic acidification but does not inhibit platelet shape change

1990 • 28 citations

Expression of c-erbB-2 in in situ and in Adjacent Invasive Ductal Adenocarcinomas of the Female

1992 • 28 citations

Nuclear and flow cytometric characteristics associated with overexpression of the c-erbB-2 oncoprotein in breast carcinoma

1991 • 22 citations