c-erbB-2 positive breast tumours behave more aggressively in the first years after diagnosis

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

1984 • 1,153 citations

The neu oncogene encodes an epidermal growth factor receptor-related protein

1986 • 1,131 citations

Neu-Protein Overexpression in Breast Cancer

1988 • 860 citations

Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project: prognostic significance of erbB-2 protein overexpression in primary breast cancer.

1990 • 602 citations

Expression of c-erbB-2 oncoprotein: a prognostic indicator in human breast cancer.

1989 • 592 citations

Correlation of c-erbB-2 gene amplification and protein expression in human breast carcinoma with nodal status and nuclear grading.

1988 • 570 citations

OVEREXPRESSION OF THE c-erbB-2 ONCOPROTEIN IN HUMAN BREAST CARCINOMAS: IMMUNOHISTOLOGICAL ASSESSMENT CORRELATES WITH GENE AMPLIFICATION

1987 • 409 citations

AMPLIFICATION OF c-erbB-2 ONCOGENE IN HUMAN ADENOCARCINOMAS IN VIVO

1986 • 400 citations

Alterations to either c-erbB-2(neu) or c-myc proto-oncogenes in breast carcinomas correlate with poor short-term prognosis.

1987 • 360 citations

c-erbB-2 protein overexpression in breast cancer is a risk factor in patients with involved and uninvolved lymph nodes

1991 • 335 citations

Correlation between long-term survival in breast cancer patients and amplification of two putative oncogene-coamplification units: hst-1/int-2 and c-erbB-2/ear-1.

1989 • 321 citations

c-erbB-2 oncoprotein expression in primary and advanced breast cancer

1991 • 245 citations

The long term prognostic significance of c-erbB-2 in primary breast cancer

1991 • 225 citations

Association of multiple copies of the c-erbB-2 oncogene with spread of breast cancer.

1987 • 214 citations

An immunohistochemical evaluation of c-erbB-2 expression in human breast carcinoma

1988 • 206 citations

Structure and expression of c‐erbB‐2 and EGF receptor genes in inflammatory and non‐inflammatory breast cancer: Prognostic significance

1989 • 197 citations

Expression of the c‐erbB‐2 protein in normal and transformed cells

1987 • 197 citations

HER-2 amplification, steroid receptors and epidermal growth factor receptor in primary breast cancer.

1989 • 150 citations

Inhibition of c-erbB-2 oncogene expression by estrogens in human breast cancer cells.

1990 • 144 citations

Proto-oncogene abnormalities in human breast cancer: correlations with anatomic features and clinical course of disease.

1987 • 143 citations

The relationship between c-erbB-2 expression, S-phase fraction and prognosis in breast cancer

1991 • 134 citations

Proto-oncogene abnormalities in human breast cancer: c-ERBB-2 amplification does not correlate with recurrence of disease.

1989 • 127 citations

Immunohistochemical distribution of c‐erbB‐2 in in situ breast carcinoma—a detailed morphological analysis

1990 • 127 citations

Analysis of c-erbB-2 expression in breast carcinomas with clinical follow-up.

1989 • 115 citations

The subcellular localization of the neu protein in human normal and neoplastic cells

1989 • 108 citations

The expression of the neu oncogene product in breast lesions and in normal fetal and adult human tissues

1989 • 105 citations

An evaluation of immunoreactivity for c-erbB-2 protein as a marker of poor short-term prognosis in breast cancer

1989 • 102 citations

c‐erbB‐2 oncogene product staining in gastric adenocarcinoma. An immunohistochemical study

1989 • 97 citations

Amplification of the c-erb B-2 oncogene and prognosis of breast adenocarcinoma.

1990 • 95 citations

The significance of oncogene amplification in primary breast cancer

1989 • 94 citations

c-erbB-2/c-erbA co-amplification indicative of lymph node metastasis, and c-myc amplification of high tumour grade, in human breast carcinoma

1989 • 72 citations

Pattern of expression of c-erbB-2 oncoprotein in human fetuses

1989 • 70 citations

Amplification of c‐myc and c‐erbB‐2 proto‐oncogenes in human solid tumors: Frequency and clinical significance

1989 • 35 citations

In situ distribution of oncogene products and growth factor receptors in breast carcinoma: c-erbB-2 oncoprotein, EGFr, and PDGFr-β-subunit

1990 • 28 citations