The Soluble Interleukin-2 Receptor: Biology, Function, and Clinical Application

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

1980 • 5,022 citations

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

The differentiation and function of human T lymphocytes

1980 • 1,548 citations

Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro.

1985 • 1,143 citations

Contingent Genetic Regulatory Events in T Lymphocyte Activation

1989 • 1,108 citations

T cell growth factor receptors. Quantitation, specificity, and biological relevance

1981 • 1,087 citations

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

1988 • 940 citations

Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

1984 • 858 citations

Novel Interleukin-2 Receptor Subunit Detected by Cross-Linking Under High-Affinity Conditions

1986 • 585 citations

Molecular cloning of cDNA encoding human interleukin-2 receptor

1984 • 567 citations

Interleukin 2 high-affinity receptor expression requires two distinct binding proteins.

1987 • 565 citations

Demonstration of a non-Tac peptide that binds interleukin 2: a potential participant in a multichain interleukin 2 receptor complex.

1986 • 477 citations

The interleukin 2 receptor. Functional consequences of its bimolecular structure.

1987 • 409 citations

Rearrangement and expression of immunoglobulin genes and expression of Tac antigen in hairy cell leukemia.

1983 • 385 citations

The released interleukin 2 receptor binds interleukin 2 efficiently.

1986 • 348 citations

Simultaneous flow cytometric analysis of human T cell activation antigen expression and DNA content.

1983 • 326 citations

A second human interleukin-2 binding protein that may be a component of high-affinity interleukin-2 receptors

1987 • 306 citations

Soluble IL-2 receptor in rheumatoid arthritis. Correlation with disease activity, IL-1 and IL-2 inhibition.

1988 • 274 citations

Cloning, sequence and expression of human interleukin-2 receptor

1984 • 272 citations

Characterization and distribution of nucleic acid sequences of a novel type C retrovirus isolated from neoplastic human T lymphocytes.

1981 • 261 citations

Interleukin 2 binding molecule distinct from the Tac protein: analysis of its role in formation of high-affinity receptors.

1987 • 252 citations

Characterization of the human receptor for T-cell growth factor.

1983 • 240 citations

A Monoclonal Antibody 7G7/B6, Binds to an Epitope on the Human Interleukin-2 (IL-2) Receptor That is Distinct From That Recognized by IL-2 or Anti-Tac

1985 • 236 citations

Immune Activation in Measles

1989 • 184 citations

Soluble interleukin-2 receptor levels in patients with undifferentiated and lymphoblastic lymphomas: correlation with survival.

1987 • 171 citations

An analysis of the cellular requirements for the production of soluble interleukin-2 receptorsin vitro

1986 • 161 citations

Detection and functional studies of p60-65 (Tac antigen) on activated human B cells.

1984 • 136 citations

In vivo administration of purified human interleukin-2 to patients with cancer: development of interleukin-2 receptor positive cells and circulating soluble interleukin-2 receptors following interleukin-2 administration.

1987 • 134 citations

Immunology of Human Immunodeficiency Virus Infection and the Acquired Immunodeficiency Syndrome

1987 • 122 citations

Soluble interleukin 2 receptor molecules in the serum of patients with autoimmune diseases

1989 • 121 citations

Soluble interleukin-2 receptors in the serum of patients with Hodgkin's disease

1987 • 116 citations

High serum interleukin-2 receptor levels are related to advanced disease and a poor outcome in childhood non-Hodgkin's lymphoma

1987 • 104 citations

Increased serum levels of soluble interleukin-2 receptor in patients with systemic lupus erythematosus and rheumatoid arthritis

1988 • 89 citations

Immune activation in multiple sclerosis: study of IL-2, sIL-2R, and γ-IFN levels in serum and cerebrospinal fluid

1989 • 88 citations

SOLUBLE INTERLEUKIN-2 RECEPTORS IN SERUM AND BILE OF LIVER TRANSPLANT RECIPIENTS

1989 • 86 citations

Serum interleukin-2-receptor in rheumatoid arthritis: A prognostic indicator of disease activity?

1988 • 85 citations

Serum soluble IL-2 receptor as a tumor marker in patients with hairy cell leukemia

1988 • 82 citations

Soluble IL-2 receptor levels in serum from blood donors seropositive for HIV.

1988 • 79 citations

Soluble IL-2 receptor in AIDS. Correlation of its serum level with the classification of HIV-induced diseases and its characterization.

1989 • 77 citations

Pulmonary Involvement in Patients with HTLV-I-associated Myelopathy: Increased Soluble IL-2 Receptors in Bronchoalveolar Lavage Fluid

1989 • 76 citations

THE SOLUBLE INTERLEUKIN‐2 RECEPTOR IN HAEMATOLOGICAL DISORDERS

1987 • 74 citations

Acute immunologic effects of interleukin-2 therapy in cancer patients: decreased delayed type hypersensitivity response and decreased proliferative response to soluble antigens.

1988 • 73 citations

SOLUBLE INTERLEUKIN-2 RECEPTOR LEVEL AS AN INDICATOR OF LIVER ALLOGRAFT REJECTION

1989 • 68 citations

Conversion of low-affinity interleukin 2 receptors to a high-affinity state following fusion of cell membranes.

1986 • 64 citations

Soluble interleukin 2 receptors are released from the cell surface of normal murine B lymphocytes stimulated with interleukin 5.

1988 • 60 citations

Prolonged Elevations of Soluble lnterleukin-2 Receptors in Tuberculosis

1989 • 50 citations

Increased Levels of Soluble lnterleukin-2 Receptor in Non-Hodgkin’s Lymphomas: Relationship with Clinical, Histologic, and Phenotypic Features

1989 • 44 citations

Elevated serum-soluble interleukin-2 receptor (Tac antigen) levels in chronic myelogenous leukemia patients with blastic crisis

1989 • 42 citations

Dynamic Changes in Soluble Interleukin-2 Receptor Levels after Lung or Heart-Lung Transplantation

1989 • 42 citations

Increased soluble interleukin-2 receptor levels in the sera of type 1 diabetic patients.

1988 • 42 citations

Immune Interventions in Disease

1987 • 40 citations

High serum levels of soluble interleukin-2 receptors in sarcoidosis.

1987 • 36 citations

Soluble interleukin 2 receptors in patients with malignant lymphoma.

1988 • 35 citations

Evolution of the levels of soluble interleukin-2 receptors during Plasmodium falciparum and P. vivax malaria

1989 • 30 citations

The human interleukin-2 receptor: a molecular and biochemical analysis of structure and function.

1987 • 28 citations

Soluble IL‐2 receptors in acute and subacute encephalitis

1987 • 26 citations

Increased serum soluble interleukin 2 receptor levels in patients with viral liver diseases.

1988 • 21 citations

Soluble interleukin-2 receptors in the serum of patients with chronic renal failure.

1988 • 21 citations

Plasma levels of soluble CD8 antigen and interleukin-2 receptor antigen in patients with hairy cell leukemia, relationship with splenectomy and with clinical response to therapy.

1989 • 14 citations

Soluble interleukin 2 receptor level in liver allograft recipients: an indicator of rejection.

1989 • 11 citations

Serum levels of soluble tac peptide in acute and chronic hepatitis B virus infection

1989 • 8 citations

Serum interleukin-2 receptor in systemic lupus erythematosus and rheumatoid arthritis.

1988 • 4 citations

[Soluble interleukin-2 receptors levels in various stages from HTLV-I infection to ATL leukaemogenesis].

1989 • 3 citations

Deleted Work

1955 • 0 citations