Dityrosine as a product of oxidative stress and fluorescent probe

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Three-dimensional structure of calmodulin

1985 • 1,035 citations

Target Enzyme Recognition by Calmodulin: 2.4 Å Structure of a Calmodulin-Peptide Complex

1992 • 1,031 citations

Protein damage and degradation by oxygen radicals. II. Modification of amino acids.

1987 • 840 citations

Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts.

1996 • 771 citations

Protein damage and degradation by oxygen radicals. III. Modification of secondary and tertiary structure.

1987 • 572 citations

Electrochemical Analysis of Protein Nitrotyrosine and Dityrosine in the Alzheimer Brain Indicates Region-Specific Accumulation

1998 • 507 citations

Peroxynitrite-Mediated Inactivation of Manganese Superoxide Dismutase Involves Nitration and Oxidation of Critical Tyrosine Residues

1998 • 506 citations

Dityrosine, a specific marker of oxidation, is synthesized by the myeloperoxidase-hydrogen peroxide system of human neutrophils and macrophages.

1993 • 486 citations

Formation of Nitrating and Chlorinating Species by Reaction of Nitrite with Hypochlorous Acid

1996 • 440 citations

Human studies related to protein oxidation: protein carbonyl content as a marker of damage.

2000 • 396 citations

Aromatic hydroxylation and nitration of phenylalanine and tyrosine by peroxynitrite

1994 • 377 citations

Tyrosine Modification by Reactive Nitrogen Species: A Closer Look

1995 • 371 citations

The Oxidation of Tyramine, Tyrosine, and Related Compounds by Peroxidase

1959 • 363 citations

Tyrosyl radical generated by myeloperoxidase catalyzes the oxidative cross-linking of proteins.

1993 • 345 citations

Tyrosyl radical generated by myeloperoxidase is a physiological catalyst for the initiation of lipid peroxidation in low density lipoprotein.

1994 • 334 citations

Positive cooperative binding of calcium to bovine brain calmodulin

1980 • 334 citations

Release of ovoperoxidase from sea urchin eggs hardens the fertilization membrane with tyrosine crosslinks

1977 • 313 citations

Mechanism of Carbon Dioxide-Catalyzed Oxidation of Tyrosine by Peroxynitrite

1996 • 297 citations

The cross-links in resilin identified as dityrosine and trityrosine

1964 • 289 citations

Liquid chromatographic determination of amino acids after gas-phase hydrolysis and derivatization with (dimethylamino)azobenzenesulfonyl chloride

1986 • 278 citations

Eosinophil Peroxidase Nitrates Protein Tyrosyl Residues

1999 • 257 citations

Evidence for roles of radicals in protein oxidation in advanced human atherosclerotic plaque

1998 • 243 citations

Kinetics of Oxidation of Tyrosine and Dityrosine by Myeloperoxidase Compounds I and II

1995 • 234 citations

Formation of o-tyrosine and dityrosine in proteins during radiolytic and metal-catalyzed oxidation

1993 • 222 citations

Regulatory and structural motifs of chicken gizzard myosin light chain kinase.

1990 • 208 citations

Dityrosine and tyrosine oxidation products are endogenous markers for the selective proteolysis of oxidatively modified red blood cell hemoglobin by (the 19 S) proteasome.

1993 • 197 citations

Ultraviolet Irradiation Effects in Poly-L-tyrosine and Model Compounds. Identification of Bityrosine as a Photoproduct^*

1967 • 191 citations

Dityrosine: Preparation, Isolation, and Analysis

1996 • 183 citations

The myoglobin protein radical. Coupling of Tyr-103 to Tyr-151 in the H2O2-mediated cross-linking of sperm whale myoglobin.

1988 • 180 citations

Characterization of a new type of cross-linkage in resilin, a rubber-like protein

1963 • 161 citations

Dityrosine is a prominent component of the yeast ascospore wall. A proof of its structure.

1986 • 159 citations

Dityrosine Formation Outcompetes Tyrosine Nitration at Low Steady-state Concentrations of Peroxynitrite

2000 • 155 citations

High affinity binding of the mastoparans by calmodulin

1983 • 154 citations

Actin carbonylation: from a simple marker of protein oxidation to relevant signs of severe functional impairment

2001 • 154 citations

Photooxidation of Phenol, Cresols, and Dihydroxybenzenes^1,2

1966 • 152 citations

Human Phagocytes Employ the Myeloperoxidase-Hydrogen Peroxide System to Synthesize Dityrosine, Trityrosine, Pulcherosine, and Isodityrosine by a Tyrosyl Radical-dependent Pathway

1996 • 147 citations

Oxidized amino acids in lens protein with age. Measurement of o-tyrosine and dityrosine in the aging human lens

1993 • 140 citations

Binding of simple peptides, hormones, and neurotransmitters by calmodulin

1982 • 139 citations

The superoxide radical reacts with tyrosine-derived phenoxyl radicals by addition rather than by electron transfer

1993 • 137 citations

Photodynamic Crosslinking of Proteins. III. Kinetics of the FMN‐ and Rose Bengal‐sensitized Photooxidation and Intermolecular Crosslinking of Model Tyrosine‐containing N‐(2‐Hydroxypropyl)methacrylamide Copolymers

1999 • 125 citations

Purification and properties of ovoperoxidase, the enzyme responsible for hardening the fertilization membrane of the sea urchin egg.

1984 • 115 citations

Evidence for dityrosine in elastin

1967 • 113 citations

Role of the Carbonate Radical Anion in Tyrosine Nitration and Hydroxylation by Peroxynitrite

2000 • 102 citations

Mechanism of the Formation and Proteolytic Release of H2O2-induced Dityrosine and Tyrosine Oxidation Products in Hemoglobin and Red Blood Cells

2001 • 100 citations

Involvement of peroxidase in chorion hardening in Aedes aegypti

1996 • 92 citations

Formation of insoluble gels and dityrosine by the action of peroxidase on soluble collagens

1968 • 88 citations

Damage of amino acids and proteins induced by nitrogen dioxide, a free radical toxin, in air

1994 • 84 citations

Dityrosine formation in calmodulin

1987 • 82 citations

Formation of dityrosine and other fluorescent amino acids by reaction of amino acids with lipid hydroperoxides

1991 • 80 citations

Fluorescence anisotropy decay demonstrates calcium-dependent shape changes in photo-cross-linked calmodulin

1988 • 79 citations

Immunochemical Detection of Protein Dityrosine in Atherosclerotic Lesion of Apo-E-Deficient Mice Using a Novel Monoclonal Antibody

2000 • 76 citations

Nitration and Oxidation of a Hydrophobic Tyrosine Probe by Peroxynitrite in Membranes: Comparison with Nitration and Oxidation of Tyrosine by Peroxynitrite in Aqueous Solution

2001 • 76 citations

Isolation of insoluble secretory product from bovine thyroid: extracellular storage of thyroglobulin in covalently cross-linked form.

1992 • 69 citations

Biochemistry of the nematode cuticle: relevance to parasitic nematodes of livestock

1993 • 67 citations

Oxidative Protein Cross-linking Reactions Involvingl-Tyrosine in Transforming Growth Factor-β1-stimulated Fibroblasts

2001 • 66 citations

The hydrogen peroxide/copper ion system, but not other metal-catalyzed oxidation systems, produces protein-bound dityrosine

2001 • 60 citations

Dityrosine Formation in Calmodulin: Cross-Linking and Polymerization Catalyzed by Arthromyces Peroxidase

1996 • 57 citations

Candida albicans cell walls contain the fluorescent cross-linking amino acid dityrosine

1995 • 44 citations

Fluorometric characterization of dityrosine: Complex formation with boric acid and borate ion

1991 • 39 citations

Purification and Characterization of Chorion Peroxidase from Aedes aegypti Eggs

2000 • 36 citations

Determination of dityrosine, phosphotyrosine, phosphothreonine, and phosphoserine by high-performance liquid chromatography

1990 • 34 citations

NADPH-initiated cytochrome P450-mediated free metal ion-independent oxidative damage of microsomal proteins. Exclusive prevention by ascorbic acid.

1994 • 32 citations

Peptides Recognizing Calmodulin

1986 • 31 citations

Hypochlorite oxidation causes cross-lingking of Lp(a)

1994 • 30 citations

Calmodulin-linked equilibria in smooth muscle myosin light chain kinase

1986 • 28 citations

Synthesis of tyrosine-derived cross-links in Ascaris suum cuticular proteins.

1993 • 28 citations

Development of fluorescence and cross-links in eye lens crystallin by interaction with lipid peroxy radicals

1991 • 27 citations

A qualitative fluorescence-based assay for tyrosyl radical scavenging activity: Ovothiol A is an efficient scavenger

1989 • 26 citations

Dityrosine Formation in Calmodulin: Conditions for Intermolecular Crosslinking

1994 • 22 citations

Analytical sedimentation studies of turkey gizzard myosin light chain kinase and telokin

1992 • 20 citations

Frequency-domain measurements of the rotational dynamics of the tyrosine groups of calmodulin

1988 • 18 citations

Time-resolved fluorescence spectroscopy. Applications to calmodulin

1991 • 10 citations

Peptide cross-linking to calmodulin: attachment of [Tyr8]substance P

1988 • 5 citations

Flexibility Involving the Intermolecular Dityrosyl Cross-Links of Enzymatically Polymerized Calmodulin

1998 • 1 citations