NADPH-initiated cytochrome P450-mediated free metal ion-independent oxidative damage of microsomal proteins. Exclusive prevention by ascorbic acid.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Superoxide Dismutase

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The Carbon Monoxide-binding Pigment of Liver Microsomes

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Age-related changes in oxidized proteins.

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Metal-catalyzed oxidation of proteins. Physiological consequences

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Protein damage and degradation by oxygen radicals. II. Modification of amino acids.

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Cytochrome P-450. Multiplicity of isoforms, substrates, and catalytic and regulatory mechanisms

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[92] The preparation and properties of microsomal TPNH-cytochrome c reductase from pig liver

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Preparation and Properties of Partially Purified Cytochrome P-450 and Reduced Nicotinamide Adenine Dinucleotide Phosphate-Cytochrome P-450 Reductase from Rabbit Liver Microsomes

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Conversion of Amino Acid Residues in Proteins and Amino Acid Homopolymers to Carbonyl Derivatives by Metal-catalyzed Oxidation Reactions

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Inactivation of key metabolic enzymes by mixed-function oxidation reactions: Possible implication in protein turnover and ageing

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Ascorbic Acid: Chemistry, Metabolism, and Uses

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Protein oxidation and proteolysis during aging and oxidative stress

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Oxidative modification of glutamine synthetase. I. Inactivation is due to loss of one histidine residue.

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Turnover of bacterial glutamine synthetase: oxidative inactivation precedes proteolysis.

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Proteins damaged by oxygen radicals are rapidly degraded in extracts of red blood cells.

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Oxidation of proteins by mixed-function oxidation systems: implication in protein turnover, ageing and neutrophil function

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Preferential degradation of the oxidatively modified form of glutamine synthetase by intracellular mammalian proteases.

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SOME PROPERTIES OF THE ASCORBATE FREE RADICAL^*

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[51] Protein degradation as an index of oxidative stress

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Purification of a liver alkaline protease which degrades oxidatively modified glutamine synthetase. Characterization as a high molecular weight cysteine proteinase.

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Increased carbonyl content of proteins in synovial fluid from patients with rheumatoid arthritis.

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Oxidation state of tissue thiol groups and content of protein carbonyl groups in chickens with inherited muscular dystrophy

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Regulation of Intracellular Protein Turnover: Covalent Modification as a Mechanism of Marking Proteins for Degradation

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Structural changes in bovine lens crystallins induced by ascorbate, metal, and oxygen

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Inactivation of Escherichia coli glutamine synthetase by xanthine oxidase, nicotinate hydroxylase, horseradish peroxidase, or glucose oxidase: Effects of ferredoxin, putidaredoxin, and menadione

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Inhibition of protein carbonyl formation and lipid peroxidation by glutathione in rat liver microsomes

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Protective role of ascorbic acid against lipid peroxidation and myocardial injury

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The role of an endogenous nonheme iron in microsomal redox reactions

1992 • 28 citations