Strategies and Methods for Research on Sex Differences in Brain and Behavior

The Physiology of Reproduction

1988 • 7,765 citations

Pharmacological implications of microsomal enzyme induction.

1967 • 2,883 citations

Physicians Desk Reference

1994 • 2,653 citations

Two Receptor Systems for Corticosterone in Rat Brain: Microdistribution and Differential Occupation

1985 • 2,530 citations

ORGANIZING ACTION OF PRENATALLY ADMINISTERED TESTOSTERONE PROPIONATE ON THE TISSUES MEDIATING MATING BEHAVIOR IN THE FEMALE GUINEA PIG¹

1959 • 1,889 citations

Hormones, Brain and Behavior

2009 • 1,548 citations

Sexual Differentiation of the Central Nervous System

1981 • 1,475 citations

The Control of Progesterone Secretion During the Estrous Cycle and Early Pseudopregnancy in the Rat: Prolactin, Gonadotropin and Steroid Levels Associated with Rescue of the Corpus Luteum of Pseudopregnancy¹²

1975 • 1,281 citations

Corticosteroid Inhibition of ACTH Secretion*

1984 • 1,212 citations

Gonadal Steroid Induction of Structural Sex Differences in the Central Nervous System

1984 • 1,170 citations

Puberty and depression: the roles of age, pubertal status and pubertal timing

1998 • 957 citations

Sexual differentiation of the brain

1981 • 911 citations

Organizational and activational effects of sex steroids on brain and behavior: A reanalysis

1985 • 811 citations

Effect of Stress on the Activity of the Hypothalamic-Pituitary-Gonadal Axis: Peripheral and Central Mechanisms1

1991 • 788 citations

Menstrual Synchrony and Suppression

1971 • 776 citations

Human behavioral sex differences: A role for gonadal hormones during early development?

1995 • 757 citations

Differential Behavioral Effects of Gonadal Steroids in Women with and in Those without Premenstrual Syndrome

1998 • 709 citations

Estrogen and/or androgen replacement therapy and cognitive functioning in surgically menopausal women

1988 • 708 citations

Variations in the Hypothalamic-Pituitary-Adrenal Response to Stress during the Estrous Cycle in the Rat

1991 • 664 citations

Salivary Cortisol: A Better Measure of Adrenal Cortical Function than Serum Cortisol

1983 • 648 citations

Exploring the Biological Contributions to Human Health

2001 • 638 citations

Testosterone Measured by 10 Immunoassays and by Isotope-Dilution Gas Chromatography–Mass Spectrometry in Sera from 116 Men, Women, and Children

2003 • 617 citations

VIVE LA DIFFÉRENCE: Males vs Females in Flies vs Worms

1996 • 601 citations

Insights from the study of animals lacking functional estrogen receptor

1994 • 587 citations

The oestrous cycle in the mouse

1922 • 547 citations

Exploring the Biological Contributions to Human Health: Does Sex Matter?

2001 • 542 citations

The oestrous cycle in the rat and its associated phenomena

1922 • 541 citations

Role of Estrogen as Initiator of Daily LH Surges in the Ovariectomized Rat¹²

1975 • 534 citations

Induction of Mating Behavior in Rats by Luteinizing Hormone-Releasing Factor

1973 • 533 citations

Testosterone influences spatial cognition in older men.

1994 • 524 citations

SEX DIFFERENCES IN ADRENAL CORTICAL SECRETION IN THE RAT¹

1961 • 522 citations

Sex Differences in Pharmacokinetics and Pharmacodynamics

2004 • 491 citations

Minireview: Sex Differences in Adult and Developing Brains: Compensation, Compensation, Compensation

2003 • 488 citations

Sex Differences and Opposite Effects of Stress on Dendritic Spine Density in the Male Versus Female Hippocampus

2001 • 477 citations

Alterations in the Hypothalamic-Pituitary-Ovarian and the Hypothalamic-Pituitary-Adrenal Axes in Athletic Women*

1989 • 473 citations

Androgens Prevent Normally Occurring Cell Death in a Sexually Dimorphic Spinal Nucleus

1985 • 470 citations

A Model System for Study of Sex Chromosome Effects on Sexually Dimorphic Neural and Behavioral Traits

2002 • 465 citations

A model system for study of sex chromosome effects on sexually dimorphic neural and behavioral traits.

2002 • 464 citations

Effect of Estrogen on Brain Activation Patterns in Postmenopausal Women During Working Memory Tasks

1999 • 431 citations

Estrogen control of central neurotransmission: Effect on mood, mental state, and memory

1996 • 426 citations

SRY AND SEX DETERMINATION IN MAMMALS

1993 • 422 citations

Testosterone influences spatial cognition in older men.

1994 • 411 citations

Sex-Related Differences in Drug Metabolism

1975 • 408 citations

Use of salivary biomarkers in biobehavioral research: cotton-based sample collection methods can interfere with salivary immunoassay results

2001 • 407 citations

The influence of ovarian steroids on hypothalamic-pituitary-adrenal regulation in the female rat

1995 • 385 citations

Hormonal factors in the sex differentiation of the mammalian foetus

1970 • 376 citations

Sex chromosomes and brain gender

2004 • 366 citations

Psychosexual Development of Women with Congenital Adrenal Hyperplasia

1996 • 349 citations

Sexually dimorphic gene expression in mouse brain precedes gonadal differentiation

2003 • 345 citations

THE ESTROGEN-PROGESTERONE INDUCTION OF MATING RESPONSES IN THE SPAYED FEMALE RAT¹

1939 • 345 citations

Hormones in saliva: mode of entry and consequent implications for clinical interpretation.

1983 • 335 citations

Convergent Pathways for Steroid Hormone- and Neurotransmitter-Induced Rat Sexual Behavior

1994 • 332 citations

Neuroendocrine Aberrations in Women With Functional Hypothalamic Amenorrhea*

1989 • 320 citations

Differentiation of coital behavior in mammals: A comparative analysis

1979 • 317 citations

Cyclic Estradiol Treatment Normalizes Body Weight and Restores Physiological Patterns of Spontaneous Feeding and Sexual Receptivity in Ovariectomized Rats

2002 • 317 citations

Human Saliva as a Diagnostic Specimen

2001 • 316 citations

Passage of Steroids Through Silicone Rubber

1966 • 309 citations

XY female mice resulting from a heritable mutation in the primary testis determining gene, Tdy

1990 • 304 citations

Sex chromosome genes directly affect brain sexual differentiation

2002 • 299 citations

Neuroendocrine Control of the Ovarian Cycle of the Rat

2006 • 298 citations

Positive and Negative Feedback Control by Estrogen of Luteinizing Hormone Secretion in the Rhesus Monkey12

1973 • 292 citations

Hormonal control of a developing neuromuscular system. II. Sensitive periods for the androgen-induced masculinization of the rat spinal nucleus of the bulbocavernosus

1983 • 280 citations

A Quantitative Analysis of the Physiological Role of Estradiol and Progesterone in the Control of Tonic and Surge Secretion of Luteinizing Hormone in the Rat*

1978 • 279 citations

Ageing of the Hypothalamo-Pituitary- Testicular Axis in Men

1995 • 273 citations

The Premenstrual Syndrome

1984 • 269 citations

Sex difference and estrous cycle variations in amphetamine-elicited rotational behavior

1982 • 268 citations

Brain aromatase is neuroprotective

2001 • 267 citations

Inhibition of Luteinizing Hormone Secretion Induced by Synthetic LRH by Long-term Treatment with Glucocorticoids in Human Subjects

1975 • 262 citations

A Beneficial Effect of Estrogen on Working Memory in Postmenopausal Women Taking Hormone Replacement Therapy

2000 • 247 citations

Role of the developing rat testis in differentiation of the neural tissues mediating mating behavior.

1965 • 247 citations

Mouse homologues of the human AZF candidate gene RBM are expressed in spermatogonia and spermatids, and map to a Y chromosome deletion interval associated with a high incidence of sperm abnormalities

1998 • 230 citations

The Temporal Relationship between Estrogen-Inducible Progestin Receptors in the Female Rat Brain and the Time Course of Estrogen Activation of Mating Behavior*

1980 • 229 citations

Hormonal control of a developing neuromuscular system. I. Complete Demasculinization of the male rat spinal nucleus of the bulbocavernosus using the anti-androgen flutamide

1983 • 223 citations

Hormone Administration: Peripheral and Intracranial Implants

1977 • 208 citations

Regulation of the human menstrual cycle

1971 • 206 citations

Cytoplasmic progestin-receptors in guinea pig brain: Characteristics and relationship to the induction of sexual behavior

1979 • 205 citations

Hormone profiles in humans experiencing military survival training

2000 • 205 citations

Effects of Estradiol and Progesterone on Catecholamine Turnover Rates in Discrete Hypothalamic Regions in Ovariectomized Rats

1981 • 204 citations

Biology of the Laboratory Mouse.

1941 • 200 citations

Pulsatile Gonadotropin Secretion in Women with Hypothalamic Amenorrhea: Evidence that Reduced Frequency of Gonadotropin-Releasing Hormone Secretion Is the Mechanism of Persistent Anovulation*

1985 • 200 citations

Ovarian and Hypothalamic Control of the Daily Surges of Prolactin Secretion During Pseudopregnancy in the Rat¹²

1974 • 198 citations

Principles of Gender-Specific Medicine

2010 • 198 citations

The contribution of adrenal and reproductive hormones to the opposing effects of stress on trace conditioning males versus females.

2001 • 192 citations

Twenty-Four-Hour ACTH and Cortisol Pulsatility in Depressed Women

2001 • 191 citations

Sexual differentiation of monoaminergic neurons - genetic or epigenetic?

1991 • 189 citations

Alteration in the Hypothalamic-Pituitary-Ovarian Axis in Depressed Women

2000 • 186 citations

Hormones in male sexual development

2000 • 185 citations

A role for ovarian hormones in sexual differentiation of the brain

1998 • 182 citations

Estrogen Receptors Are Essential for Female Sexual Receptivity

1997 • 177 citations

Stability of salivary steroids: the influences of storage, food and dental care

2001 • 176 citations

Reliability and validity of a daily diary for premenstrual syndrome

1996 • 175 citations

Induction of Estrous Behavior in Ovariectomized Rats by Sequential Replacement of Estrogen and Progesterone to the Ventromedial Hypothalamus

1983 • 173 citations

Are XX and XY brain cells intrinsically different?

2003 • 166 citations

GnRH Release from the Mediobasal Hypothalamus: in vitro Inhibition by Corticotropin-Releasing Factor

1986 • 166 citations

Chronobiological aspects of endocrinology.

1974 • 162 citations

The length of heat in the albino rat as determined by the copulatory response

1941 • 161 citations

Spontaneous meal patterns in female rats with and without access to running wheels

2000 • 161 citations

Sex determination in marsupials: evidence for a marsupial—eutherian dichotomy

1988 • 158 citations

Steroid Receptor Levels in Intact and Ovariectomized Estrogen-Treated Rats: An Examination of Quantitative, Temporal and Endocrine Factors Influencing the Efficacy of an Estradiol Stimulus

1981 • 158 citations

Successful Treatment of Severe Premenstrual Syndrome by Combined Use of Gonadotropin-Releasing Hormone Agonist and Estrogen/Progestin*

1991 • 157 citations

A Y-chromosomal effect on blastocyst cell number in mice

1993 • 156 citations

Hormonal control of sexual receptivity during the estrous cycle of the rat

1970 • 154 citations

Hormones in Saliva

1986 • 154 citations

CIRCANNUAL CYCLE IN PLASMA TESTOSTERONE LEVELS IN MAN.

1976 • 154 citations

Stimulation of Female Sex Behavior in Adrenalectomized Rats with Estrogen Alone

1968 • 150 citations

A conceptual model of the influence of stress on female reproduction

2003 • 149 citations

Hypercortisolism in Patients With Functional Hypothalamic-Amenorrhea*

1988 • 149 citations

Puberty and the maturation of the male brain and sexual behavior: recasting a behavioral potential

2002 • 147 citations

Impact of Continuously Administered Catechol Estrogens on Uterine Growth and Luteinizing Hormone Secretion*

1979 • 146 citations

Feminine Sexual Behavior

2002 • 145 citations

Sexual Differentiation of the Brain

1981 • 145 citations

Human salivary steroids: Methodological considerations and applications in physical anthropology

1988 • 144 citations

Synaptic remodelling in arcuate nucleus after injection of estradiol valerate in adult female rats

1986 • 142 citations

Behavioral Effects of PrenatalVersusPostnatal Androgen Excess in Children with 21-Hydroxylase-Deficient Congenital Adrenal Hyperplasia¹

2000 • 137 citations

Latency between intravenous injection of progestins and the appearance of estrous behavior in estrogen-treated ovariectomized rats

1972 • 137 citations

SEX IN THE 90s: SRY and the Switch to the Male Pathway

1998 • 137 citations

Direct Radioimmunoassay (RIA) of salivary testosterone: correlation with free and total serum testosterone

1985 • 136 citations

Spatial reference memory and neocortical neurochemistry vary with the estrous cycle in C57BL/6 mice.

2001 • 133 citations

Estrous Cyclicity in Mammals

1981 • 133 citations

Biology of the Laboratory Mouse

1942 • 132 citations

Estrous synchrony: Modulation of ovarian cycle length by female pheromones

1984 • 130 citations

Neurotrophin expression in the reproductively senescent forebrain is refractory to estrogen stimulation

2001 • 129 citations

Induction of receptivity in ovariectomized female rats by a single intravenous injection of estradiol-17β

1970 • 128 citations

Mechanisms for Ovarian Cycle Disruption by Immune/inflammatory Stress

2002 • 126 citations

Tricyclic dose requirements across pregnancy

1993 • 119 citations

A Discontinuous Schedule of Estradiol Treatment Is Sufficient to Activate Progesterone-Facilitated Feminine Sexual Behavior and to Increase Cytosol Receptors for Progestins in the Hypothalamus of the Rat

1982 • 116 citations

GENE INTERACTIONS IN GONADAL DEVELOPMENT

1999 • 114 citations

Psychobiology of Sexual Behavior in the Guinea Pig

1969 • 114 citations

Neuroendocrine Control of the Ovarian Cycle of the Rat

2014 • 111 citations

The relation of serum 17-hydroxyprogesterone and estradiol-17β levels during the human menstrual cycle

1971 • 110 citations

A Window for the Study of Prenatal Sex Hormone Influences on Postnatal Development

1989 • 107 citations

Plasma Monoamine Oxidase Activity in Regularly Menstruating Women and in Amenorrheic Women Receiving Cyclic Treatment with Estrogens and a Progestin

1971 • 107 citations

Ovarian hormones after postnatal day 20 reduce neuron number in the rat primary visual cortex

2002 • 103 citations

Spatial cognition in humans: possible modulation by androgens and estrogens.

1995 • 102 citations

Sensitive salivary estradiol assay for monitoring ovarian function

1990 • 101 citations

Short stressor induced long-lasting increases of vasopressin stores in hypothalamic corticotropin-releasing hormone (CRH) neurons in adult rats.

1996 • 101 citations

Androgen deprivation and cognition in prostate cancer

2003 • 100 citations

Variation in maternal care and individual differences in play, exploration, and grooming of juvenile Norway rat offspring

1992 • 97 citations

Sexual differentiation of the brain and behavior.

2002 • 94 citations

OESTRADIOL-17α AND PITUITARY RESPONSIVENESS TO LUTEINIZING HORMONE RELEASING FACTOR IN THE RAT: A STUDY USING RECTANGULAR PULSES OF OESTRADIOL-17β MONITORED BY NON-CHROMATOGRAPHIC RADIOIMMUNOASSAY

1977 • 92 citations

Inhibition of sexual behavior in female guinea pigs by a progestin receptor antagonist

1984 • 90 citations

Short Stressor Induced Long‐Lasting Increases of Vasopressin Stores in Hypothalamic Corticotropin‐Releasing Hormone (CRH) Neurons in Adult Rats

1996 • 89 citations

Maternal behavior of rats is affected by hormonal condition of pups.

1982 • 87 citations

Accuracy of the peak day of cervical mucus as a biological marker of fertility

2002 • 83 citations

Temporal relationship between cell nuclear progestin receptor levels and sexual receptivity following intravenous progesterone administration

1981 • 81 citations

Does Cortisol Mediate Endotoxin-Induced Inhibition of Pulsatile Luteinizing Hormone and Gonadotropin-Releasing Hormone Secretion?

2002 • 80 citations

Steroid Hormone Analysis in Human Saliva

1993 • 80 citations

Hypothalamo-Pituitary-Adrenocortical Regulation Following Lesions of the Central Nucleus of the Amygdala

1997 • 80 citations

Antiestrogens: Effects of tamoxifen, nafoxidine, and CI-628 on sexual behavior, cytoplasmic receptors, and nuclear binding of estrogen

1979 • 78 citations

Concepts of Genetic and Hormonal Induction of Vertebrate Sexual Differentiation in the Twentieth Century, with Special Reference to the Brain

2002 • 75 citations

Sex differences in the effects of gonadectomy on amphetamine-induced rotational behavior in rats

1986 • 74 citations

Individual differences in changes in mood and platelet monoamine oxidase (MAO) activity during hormonal replacement therapy in menopausal women

1996 • 71 citations

Imipramine disposition in users of oral contraceptive steroids

1984 • 70 citations

Social Recognition in Ovariectomized and Estradiol-Treated Female Rats

1993 • 69 citations

Induction of estrus in female mice: Estrogen-progesterone interactions

1970 • 69 citations

THE USE OF AN LHRH AGONIST, BUSERELIN, IN THE LONG‐TERM MANAGEMENT OF PREMENSTRUAL SYNDROMES

1987 • 66 citations

Status Report on Measurement of Salivary Estrogens and Androgens

1993 • 65 citations

Serotonin in the Central Nervous System and Periphery.

1997 • 63 citations

Attenuation by a 5a-Reductase Inhibitor of the Activational Effect of Testosterone Propionate on Penile Erections in Castrated Male Rats*

1981 • 62 citations

Progesterone facilitation of lordosis in male and female Sprague-Dawley rats following priming with estradiol pulses

1988 • 60 citations

A Comparison of Antidepressant Response in Younger and Older Women

2003 • 59 citations

PSYCHONEUROENDOCRINOLOGY OF DEPRESSION

1998 • 59 citations

Sex Reversals in the Mating Pattern of the Rat

1938 • 59 citations

Sex differences in mouse cortical thickness are independent of the complement of sex chromosomes

2003 • 59 citations

Facilitation and Inhibition of the Estrogen-Induced Luteinizing Hormone Surge in the Rat by Progesterone: Effects on Cytoplasmic and Nuclear Estrogen Receptors in the Hypothalamus-Preoptic Area, Pituitary, and Uterus*

1981 • 55 citations

Measurements of Salivary Progesterone^a

1993 • 55 citations

Inhibition of Estrous Behavior by Progesterone in Rats: Role of Neural Estrogen and Progestin Receptors*

1979 • 54 citations

Biology and receptor interactions of estriol and estriol derivatives in vitro and in vivo

1984 • 53 citations

INDUCTION OF SEXUAL RECEPTIVITY IN OVARIECTOMIZED RATS BY PULSE ADMINISTRATION OF OESTRADIOL-17β

1981 • 51 citations

Saliva Estriol Measurements: An Alternative to the Assay of Serum Unconjugated Estriol in Assessing Feto- Placental Function

1983 • 50 citations

Induction of CCK mRNA levels in the limbic-hypothalamic circuit: Time course and site-specific effects of estrogen

1996 • 50 citations

Onset of the receptive and proceptive components of feminine sexual behavior in rats following the intravenous administration of progesterone

1983 • 50 citations

Maintenance of Progesterone-Facilitated Sexual Behavior in Female Rats Requires Continued Hypothalamic Protein Synthesis and Nuclear Progestin Receptor Occupation*

1987 • 48 citations

The Pharmacologic Treatment of Depression

2002 • 44 citations

EFFECTS OF STEROID HORMONES ON GONADOTROPHIN SECRETION IN FEMALE RATS AFTER OVARIECTOMY DURING THE OESTROUS CYCLE

1974 • 42 citations

Experiential and strain determinants of the estrogen-progesterone induction of sexual receptivity in spayed female mice

1971 • 42 citations

Sex differences in adult and developing brains; compensation, compensation, compensation

2004 • 40 citations

A hormonal basis for sex differences in the self-grooming of rats

1986 • 40 citations

Severe rheumatoid arthritis prohibits the pregnancy-induced decrease in alpha3-fucosylation of alpha1-acid glycoprotein.

1998 • 38 citations

The role of estrogen and progesterone in the control of preputial gland sex attractant odors in the female rat

1982 • 36 citations

PULSE ADMINISTRATION OF ESTRADIOL-17β CANCELS SEX DIFFERENCE IN BEHAVIORAL ESTROGEN SENSITIVITY

1983 • 36 citations

Long-term retention of estradiol by brain cell nuclei and female rat sexual behavior

1979 • 35 citations

On the Nature of Mammalian and Human Pheromones

1998 • 34 citations

Alteration of Oocytes and Follicles by Delayed Ovulation1

1970 • 34 citations

Male and female mating behavior in prepubertally castrated male rats receiving estrogens.

1939 • 33 citations

Estrogen conditioning and progesterone facilitation of lordosis in guinea pigs

1971 • 33 citations

Hormones in Development and Aging

1981 • 32 citations

Phenotype characteristics of transgenic male mice expressing human aromatase under ubiquitin C promoter

2003 • 31 citations

Biochemical and Immunocytochemical Assessment of Neural Progestin Receptors Following Estradiol Treatments that Eliminate the Sex Difference in Progesterone‐Facilitated Lordosis in Guinea‐Pigs

1990 • 30 citations

Effect of Different Chronic Intermittent Stressors and Acetyl-/-Carnitine on Hypothalamic β-Endorphin and GnRH and on Plasma Testosterone Levels in Male Rats

1993 • 29 citations

Inhibitory and facilitatory effects of various anti-estrogens on the induction of female sexual behavior by estradiol benzoate in guinea pigs

1977 • 29 citations

Direct solid-phase chemiluminescence immunoassay for salivary progesterone.

1986 • 27 citations

Fluctuating levels of antidepressants premenstrually

1992 • 25 citations

Mechanisms of Stress on Reproduction: Evidence for a Complex Intra-Hypothalamic Circuit

1998 • 25 citations

Immediate and residual effects of tamoxifen and ethynylestradiol in the female rat hypothalamus

2003 • 22 citations

Neuromodulatory regulation of gonadotropin-releasing hormone pulsatile discharge in women

1990 • 21 citations

Priming Action of Estrogen: Minimum Duration of Exposure for Feedback and Behavioral Effects

1979 • 21 citations

A prototype for ovulation detection: Pros and cons

1991 • 21 citations

Infravesical Obstruction in Aromatase Over Expressing Transgenic Male Mice With Increased Ratio of Serum Estrogen-To-Androgen Concentration

2002 • 21 citations

Effective intervals for the administration of estradiol pulses and the induction of sexual behavior in female rats

1987 • 20 citations

Pain: Sex/Gender Differences

2009 • 18 citations

Development of steroid-induced lordosis in female guinea pigs: Effects of different estradiol and progesterone treatments, clonidine, and early weaning

1989 • 17 citations

Source of Ovarian Preovulatory Progesterone

1971 • 16 citations

Handbook of female psychopharmacology

2004 • 9 citations

Hormonal and Nonhormonal Mechanisms of Sexual Differentiation of the Brain

2004 • 5 citations

Psychopharmacology During Pregnancy and Lactation

2024 • 1 citations