Brain aromatase is neuroprotective

Sexual Differentiation of the Central Nervous System

1981 • 1,475 citations

Estrogen Actions in the Central Nervous System¹

1999 • 1,381 citations

Estrogen Replacement Therapy for Treatment of Mild to Moderate Alzheimer Disease

2000 • 985 citations

Neuroprotection by estradiol

2001 • 922 citations

Neuroprotection against Oxidative Stress by Estrogens: Structure-Activity Relationship

1997 • 769 citations

Estrogen Actions in the Central Nervous System

1999 • 641 citations

Estrogen Replacement Therapy in Older Women

1994 • 596 citations

Estrogen for Alzheimer’s disease in women

2000 • 555 citations

Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides

1998 • 545 citations

Neuroprotective effects of estrogens: potential mechanisms of action

2000 • 515 citations

Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat

1997 • 512 citations

Neuron loss, granule cell axon reorganization, and functional changes in the dentate gyrus of epileptic kainate‐treated rats

1997 • 501 citations

A review of brain aromatase cytochrome P450

1996 • 492 citations

Estradiol Modulates bcl-2 in Cerebral Ischemia: A Potential Role for Estrogen Receptors

1999 • 453 citations

Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity

1998 • 444 citations

Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it.

1992 • 442 citations

Neurosteroidogenesis in Astrocytes, Oligodendrocytes, and Neurons of Cerebral Cortex of Rat Brain

1999 • 432 citations

Neuron loss, granule cell axon reorganization, and functional changes in the dentate gyrus of epileptic kainate-treated rats

1997 • 400 citations

Aromatase expression by astrocytes after brain injury: implications for local estrogen formation in brain repair

1999 • 366 citations

Estrogen protects primary cortical neurons from glutamate toxicity

1996 • 329 citations

AROMATIZATION OF ANDROSTENEDIONE BY THE DIENCEPHALON¹

1971 • 320 citations

Neurosteroids: Deficient cognitive performance in aged rats depends on low pregnenolone sulfate levels in the hippocampus

1997 • 299 citations

Testosterone reduces neuronal secretion of Alzheimer's β-amyloid peptides

2000 • 292 citations

Disruption of Sexual Behavior in Male Aromatase-Deficient Mice Lacking Exons 1 and 2 of thecyp19Gene

1998 • 288 citations

17β-Estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors

1997 • 278 citations

BDNF Mediates the Effects of Testosterone on the Survival of New Neurons in an Adult Brain

1999 • 267 citations

Role of astroglia in estrogen regulation of synaptic plasticity and brain repair

1999 • 266 citations

Estradiol protects mesencephalic dopaminergic neurons from oxidative stress-induced neuronal death

1998 • 242 citations

Neuroprotective effects of estradiol in the adult rat hippocampus: Interaction with insulin-like growth factor-I signalling

1999 • 196 citations

Testosterone increases and estradiol decreases middle cerebral artery occlusion lesion size in male rats

1998 • 187 citations

Neuroprotection by Estrogens in a Mouse Model of Focal Cerebral Ischemia and in Cultured Neurons: Evidence for a Receptor-Independent Antioxidative Mechanism

1999 • 183 citations

Dehydroepiandrosterone and its sulfated derivative reduce neuronal death and enhance astrocytic differentiation in brain cell cultures

1987 • 174 citations

Neuroprotective Effects of Estrogens on Hippocampal Cells in Adult Female Rats After Status Epilepticus

2000 • 161 citations

Estrogen Receptor Antagonist ICI182,780 Exacerbates Ischemic Injury in Female Mouse

2000 • 158 citations

Analysis of cell death in the trochlear nucleus of the chick embryo: Calibration of the optical disector counting method reveals systematic bias

1999 • 155 citations

Two weeks of transdermal estradiol treatment in postmenopausal elderly women and its effect on memory and mood: verbal memory changes are associated with the treatment induced estradiol levels

1999 • 148 citations

Estrogen decreases corpus striatal neurotoxicity in response to 6-hydroxydopamine

1997 • 144 citations

Estrogens attenuate neuronal injury due to hemoglobin, chemical hypoxia, and excitatory amino acids in murine cortical cultures

1997 • 138 citations

The female sex hormone oestrogen as a neuroprotectant

1999 • 137 citations

Hippocampal damage produced by systemic injections of domoic acid in mice

1991 • 135 citations

Rapid Upregulation of Aromatase mRNA and Protein Following Neural Injury in the Zebra Finch (Taeniopygia guttata)

2001 • 132 citations

The Role of Aromatization in the Restoration of Male Rat Reproductive Behavior

1997 • 129 citations

Domoic Acid Neurotoxicity in Cultured Cerebellar Granule Neurons Is Mediated Predominantly by NMDA Receptors that Are Activated as a Consequence of Excitatory Amino Acid Release

1997 • 128 citations

β-Estradiol protects hippocampal CA1 neurons against transient forebrain ischemia in gerbil

1997 • 126 citations

Estradiol protects against injury-induced cell death in cortical explant cultures: a role for estrogen receptors

2000 • 126 citations

Expression of CYP19 (aromatase) mRNA in different areas of the human brain

1999 • 125 citations

Trophic Effects of Estradiol on Fetal Rat Hypothalamic Neurons

1992 • 104 citations

The heat shock-induced hyperphosphorylation of τ is estrogen-independent and prevented by androgens: Implications for Alzheimer disease

1997 • 89 citations

Glutamate receptor requirement for neuronal death from anoxia-reoxygenation: an in Vitro model for assessment of the neuroprotective effects of estrogens.

1999 • 88 citations

Effect of testosterone on the regeneration of the hypoglossal nerve in rats

1982 • 87 citations

Intracerebral Infusion of an Aromatase Inhibitor, Sexual Behavior and Brain Estrogen Receptor-Like Immunoreactivity in Intact Male Rats

1995 • 86 citations

Gonadal hormones affect neuronal vulnerability to excitotoxin-induced degeneration.

1999 • 81 citations

Estrogens in the Pathogenesis and Treatment of Alzheimer's Disease in Postmenopausal Women

1994 • 79 citations

Effects of the nonsteroidal aromatase inhibitor, Fadrozole, on sexual behavior in male rats

1992 • 76 citations

Estrogen protects against while testosterone exacerbates vulnerability of the lateral striatal artery to chemical hypoxia by 3-nitropropionic acid

1998 • 74 citations

Neuroprotective effects of chronic estradiol benzoate treatment on hippocampal cell loss induced by status epilepticus in the female rat

2000 • 69 citations

Hormonal control of behaviour: steroid action in the brain

1991 • 61 citations

17 β-Estradiol Attenuates Fimbrial Lesion-Induced Decline of ChAT-Immunoreactive Neurons in the Rat Medial Septum

1997 • 58 citations

Trophic Effects of Androgen: Receptor Expression and the Survival of Laryngeal Motor Neurons after Axotomy

1996 • 47 citations

Effects of Testosterone and Aromatase Inhibition on Estrogen Receptor-Like Immunoreactivity in Male Rat Brain

1994 • 44 citations

Androgenic Enhancement of Motor Neuron Regeneration

1994 • 40 citations

In vitro potency and selectivity of the non-steroidal androgen aromatase inhibitor CGS 16949A compared to steroidal inhibitors in the brain

1992 • 38 citations

Domoic acid-induced neurodegeneration resulting in memory loss is mediated by Ca2+ overload and inhibition of Ca2+ + calmodulin-stimulated adenylate cyclase in rat brain (review).

2000 • 30 citations