Splice variants as cancer biomarkers

Mechanisms of Alternative Pre-Messenger RNA Splicing

2003 • 2,547 citations

Listening to silence and understanding nonsense: exonic mutations that affect splicing

2002 • 2,143 citations

An extensive network of coupling among gene expression machines

2002 • 1,137 citations

Pitfalls in the Use of DNA Microarray Data for Diagnostic and Prognostic Classification

2002 • 1,013 citations

Genome-wide detection of alternative splicing in expressed sequences of human genes

2001 • 688 citations

The New Human Tissue Kallikrein Gene Family: Structure, Function, and Association to Disease*

2001 • 636 citations

CD44 in Cancer

2002 • 526 citations

Two Splice Variants of the Wilms' Tumor 1 Gene Have Distinct Functions during Sex Determination and Nephron Formation

2001 • 522 citations

Genomewide Analysis of mRNA Processing in Yeast Using Splicing-Specific Microarrays

2002 • 406 citations

Underediting of glutamate receptor GluR-B mRNA in malignant gliomas

2001 • 375 citations

Mutations affecting mRNA splicing are the most common molecular defects in patients with neurofibromatosis type 1

2000 • 354 citations

Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiation

2003 • 350 citations

Functional association between promoter structure and transcript alternative splicing

1997 • 340 citations

De Novo Ceramide Regulates the Alternative Splicing of Caspase 9 and Bcl-x in A549 Lung Adenocarcinoma Cells

2002 • 331 citations

Proteomic Patterns in Biological Fluids: Do They Represent the Future of Cancer Diagnostics?

2003 • 326 citations

Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers.

2001 • 278 citations

A functional p53-responsive intronic promoter is contained within the humanmdm2gene

1995 • 271 citations

The New Human Tissue Kallikrein Gene Family: Structure, Function, and Association to Disease

2001 • 268 citations

Localization of BRCA1 and a Splice Variant Identifies the Nuclear Localization Signal

1997 • 233 citations

Profiling alternative splicing on fiber-optic arrays

2002 • 211 citations

Alternative and aberrant splicing of MDM2 mRNA in human cancer

2002 • 192 citations

Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer

1997 • 191 citations

Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors

2003 • 186 citations

Stage-specific changes in SR splicing factors and alternative splicing in mammary tumorigenesis

1999 • 181 citations

Discovery of novel splice forms and functional analysis of cancer-specific alternative splicing in human expressed sequences

2003 • 175 citations

RNA hyperediting and alternative splicing of hematopoietic cell phosphatase (PTPN6) gene in acute myeloid leukemia

2000 • 162 citations

The complex life of WT1

2003 • 147 citations

Regulation of Ich-1 pre-mRNA alternative splicing and apoptosis by mammalian splicing factors

1998 • 144 citations

TID1, a human homolog of theDrosophilatumor suppressorl(2)tid, encodes two mitochondrial modulators of apoptosis with opposing functions

1999 • 142 citations

Antagonistic effects of T-Ag and VP16 reveal a role for RNA pol II elongation on alternative splicing

2001 • 141 citations

An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2

2001 • 140 citations

Differential alternative splicing activity of isoforms of polypyrimidine tract binding protein (PTB)

2001 • 133 citations

In prostatism patients the ratio of human glandular kallikrein to free PSA improves the discrimination between prostate cancer and benign hyperplasia within the diagnostic “gray zone” of total PSA 4 to 10 ng/mL

1998 • 133 citations

Proteomic Approaches to the Diagnosis, Treatment, and Monitoring of Cancer

2003 • 127 citations

Altered Expression of Fibroblast Growth Factor Receptors in Human Pituitary Adenomas

1997 • 126 citations

Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers.

2003 • 109 citations

Alternative splicing of fibroblast growth factor receptors in human prostate cancer

2001 • 93 citations

Fibroblast growth factor receptor-1 alpha-exon exclusion and polypyrimidine tract-binding protein in glioblastoma multiforme tumors.

2000 • 91 citations

HUMAN GLANDULAR KALLIKREIN 2: A POTENTIAL SERUM MARKER FOR PREDICTING THE ORGAN CONFINED VERSUS NONORGAN CONFINED GROWTH OF PROSTATE CANCER

2000 • 88 citations

Characterization of functional messenger RNA splice variants of BRCA1 expressed in nonmalignant and tumor-derived breast cells.

1996 • 80 citations

Differentiating pathogenic mutations from polymorphic alterations in the splice sites of BRCA1 and BRCA2

2003 • 78 citations

Safety and biodistribution of 99mTechnetium-labeled anti-CD44v6 monoclonal antibody BIWA 1 in head and neck cancer patients.

2000 • 73 citations

Coexpression of CD44 variant (v10/ex14) and CD44S in human mammary epithelial cells promotes tumorigenesis

1997 • 68 citations

Expression and Prognostic Value of CD44 Standard and Variant v3 and v6 Isoforms in Prostate Cancer

2001 • 65 citations

Alternative Pre-mRNA Splicing and Regulation of Programmed Cell Death

2003 • 64 citations

The human caspase-2 gene: alternative promoters, pre-mRNA splicing and AUG usage direct isoform-specific expression

2003 • 56 citations

Identification and molecular characterization of five novel kallikrein gene 13 (KLK13; KLK-L4) splice variants: differential expression in the human testis and testicular cancer.

2002 • 51 citations

Computational Analysis of Alternative Splicing Using EST Tissue Information

2002 • 51 citations

Gene expression in cancer: the application of microarrays

2003 • 50 citations

Heparan sulfate enhances invasion by human colon carcinoma cell lines through expression of CD44 variant exon 3.

2001 • 49 citations

Expression of CD44 Isoforms Correlates With the Metastatic Potential of Osteosarcoma

2002 • 47 citations

Increased level of exon 12 alternatively spliced BRCA2 transcripts in tumor breast tissue compared with normal tissue.

1999 • 47 citations

Quantitative analysis of hippostasin/KLK11 gene expression in cancerous and noncancerous prostatic tissues

2003 • 44 citations

Function and dysfunction of the human oncoprotein MDM2

2002 • 43 citations

CD44V6 in Gastric Carcinoma: A Marker of Tumor Progression

2001 • 41 citations

Control of Alternative Pre‐mRNA Splicing by RNA Pol II Elongation: Faster is Not Always Better

2003 • 40 citations

Complex alternative splicing of the hKLK3 gene coding for the tumor marker PSA (prostate‐specific‐antigen)

2003 • 39 citations

A Soluble Dominant Negative Fibroblast Growth Factor Receptor 4 Isoform in Human MCF-7 Breast Cancer Cells

2001 • 37 citations

Detection of metastatic prostate cancer using a splice variant-specific reverse transcriptase-polymerase chain reaction assay for human glandular kallikrein.

2000 • 36 citations

Identification and Characterization of Soluble Isoform of Fibroblast Growth Factor Receptor 3 in Human SaOS-2 Osteosarcoma Cells

2002 • 35 citations

Antisense inhibition of CD44 tailless splice variant in human articular chondrocytes promotes hyaluronan internalization

2001 • 34 citations

WT1 splicing alterations in Wilms' tumors.

2000 • 32 citations

Polypyrimidine tract-binding protein down-regulates fibroblast growth factor receptor 1 alpha-exon inclusion.

2003 • 31 citations

A Directly Spliced Exon 10–Containing CD44 Variant Promotes the Metastasis and Homotypic Aggregation of Aggressive Non-Hodgkin's Lymphoma

1998 • 29 citations

Prostate cancer overexpresses CD44 variants 7-9 at the messenger RNA and protein level.

2003 • 29 citations

Altered Expression of Fibroblast Growth Factor Receptors in Human Pituitary Adenomas

1997 • 27 citations

Ligand Activation of Alternatively Spliced Fibroblast Growth Factor Receptor-1 Modulates Pancreatic Adenocarcinoma Cell Malignancy

2002 • 25 citations

Qualitative gene profiling: a novel tool in genomics and in pharmacogenomics that deciphers messenger RNA isoforms diversity

2000 • 25 citations

Alternatively spliced MDM2 transcripts in human breast cancer in relation to tumor necrosis and lymph node involvement

2000 • 24 citations

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2001 • 18 citations

Prognostic significance of CD44v5 expression in human thymic epithelial neoplasms

2003 • 16 citations

Function and dysfunction of the human oncoprotein MDM2

2002 • 11 citations

Detection of circulating prostate tumor cells: alternative spliced variant of PSM induced false-positive result.

2002 • 8 citations

CD44v10: An Antimetastatic Membrane Glycoprotein for Pancreatic Cancer

2003 • 6 citations

Expression of CD44 in primary lung carcinomas using histological and cytological analyses.

2003 • 5 citations

CD44v10: An antimetastatic membrane glycoprotein for pancreatic cancer

2003 • 5 citations