Relationship of neurologic status in macaques infected with the simian immunodeficiency virus to cerebrospinal fluid quinolinic acid and kynurenic acid

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1986 • 3,586 citations

Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy

1986 • 1,694 citations

The AIDS Dementia Complex

1988 • 1,387 citations

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

1986 • 1,283 citations

Quinolinic Acid: An Endogenous Metabolite That Produces Axon-Sparing Lesions in Rat Brain

1983 • 1,247 citations

The Brain in AIDS: Central Nervous System HIV-1 Infection and AIDS Dementia Complex

1988 • 1,244 citations

Anatomical organization of excitatory amino acid receptors and their pathways

1987 • 877 citations

Blood–Brain Barrier Transport of Kynurenines: Implications for Brain Synthesis and Metabolism

1991 • 705 citations

Zinc Selectively Blocks the Action of N -Methyl-D-Aspartate on Cortical Neurons

1987 • 678 citations

Secretion of Neurotoxins by Mononuclear Phagocytes Infected with HIV-1

1990 • 628 citations

HIV-1 Coat Protein Neurotoxicity Prevented by Calcium Channel Antagonists

1990 • 595 citations

Quinolinic acid in cerebrospinal fluid and serum in HIV‐1 Infection: Relationship to clinical and neurological status

1991 • 563 citations

Two classes of N-methyl-D-aspartate recognition sites: differential distribution and differential regulation by glycine.

1988 • 495 citations

Neurotoxicity of excitatory amino acids

1990 • 466 citations

Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid

1984 • 416 citations

Synergistic effects of HIV coat protein and NMDA receptor-mediated neurotoxicity

1991 • 397 citations

Tryptophan degradation in mice initiated by indoleamine 2,3-dioxygenase.

1986 • 372 citations

Loss of neurons in the frontal cortex in AIDS brains

1990 • 355 citations

l-Kynurenine Its synthesis and possible regulatory function in brain

1980 • 299 citations

Animal models of AIDS

1989 • 219 citations

Identification and quantification of kynurenic acid in human brain tissue

1988 • 217 citations

Human macrophages degrade tryptophan upon induction by interferon-gamma

1987 • 182 citations

Induction of Tryptophan DegradationIn VitroandIn Vivo: A γ-Interferon-Stimulated Activity

1986 • 181 citations

Localization of simian immunodeficiency virus in the central nervous system of rhesus monkeys.

1991 • 177 citations

Prolonged exposure to submicromolar concentrations of quinolinic acid causes excitotoxic damage in organotypic cultures of rat corticostriatal system

1989 • 175 citations

Kynurenic acid and quinolinic acid act at N-methyl-D-aspartate receptors in the rat hippocampus.

1986 • 174 citations

Cerebrospinal fluid neopterin in human immunodeficiency virus type 1 infection

1990 • 161 citations

Quinolinate neurotoxicity in cortical cell culture

1987 • 146 citations

Quinolinic acid: regional variations in neuronal sensitivity

1983 • 145 citations

Interferons and indoleamine 2,3-dioxygenase: Role in antimicrobial and antitumor effects

1989 • 139 citations

Neopterin and interferon‐gamma in serum and cerebrospinal fluid of patients with HIV‐associated neurologic disease

1991 • 138 citations

Quantification of quinolinic acid in rat brain, whole blood, and plasma by gas chromatography and negative chemical ionization mass spectrometry: Effects of systemic l-tryptophan administration on brain and blood quinolinic acid concentrations

1988 • 126 citations

Comparison of simian immunodeficiency virus and human immunodeficiency virus encephalitides in the immature host

1988 • 118 citations

Studies on the disposition of quinolinic acid after intracerebral or systemic administration in the rat

1984 • 115 citations

Brain Quinolinic Acid in Huntington's Disease

1988 • 111 citations

Determination of serum kynurenine and hepatic tryptophan dioxygenase activity by high-performance liquid chromatography

1988 • 111 citations

Immune Activation and Decreased Tryptophan in Patients with HIV-1 Infection

1990 • 105 citations

Cerebrospinal fluid levels of quinolinic acid in Huntington's disease and schizophrenia

1988 • 105 citations

Simian immunodeficiency virus?induced meningoencephalitis: Natural history and retrospective study

1988 • 97 citations

Elevated neopterin and beta2-microglobulin levels in blood and cerebrospinal fluid occur early in HIV-1 infection

1989 • 88 citations

Tryptophan Degradation in Patients Infected by Human Immunodeficiency Virus

1988 • 83 citations

Cerebrospinal fluid ß ₂ microglobulin in patients infected with human immunodeficiency virus

1989 • 80 citations

Increased Cerebrospinal Fluid Quinolinic Acid, Kynurenic Acid, and L‐Kynurenine in Acute Septicemia

1990 • 80 citations

Chronic effects of γ-interferon on quinolinic acid and indoleamine-2,3-dioxygenase in brain of C57BL6 mice

1991 • 80 citations

Systemic endotoxin increasesl-tryptophan, 5-hydroxyindoleacetic acid, 3-hydroxykynurenine and quinolinic acid content of mouse cerebral cortex

1989 • 76 citations

Presence of 3‐Hydroxyanthranilic Acid in Rat Tissues and Evidence for Its Production from Anthranilic Acid in the Brain

1990 • 74 citations

Increased ratio of quinolinic acid to kynurenic acid in cerebrospinal fluid of D retrovirus—infected rhesus macaques: Relationship to clinical and viral status

1990 • 73 citations

Regional brain and cerebrospinal fluid quinolinic acid concentrations in Huntington's disease

1991 • 69 citations

Serial pathogenesis study of SIV brain infection.

1991 • 62 citations

Simian retrovirus D serogroup 1 has a broad cellular tropism for lymphoid and nonlymphoid cells

1988 • 60 citations

Early SIV encephalopathy

1991 • 60 citations

Quantification of kynurenic acid in cerebrospinal fluid: effects of systemic and central l-kynurenine administration

1990 • 54 citations

Interferon: A mediator of indoleamine 2,3-dioxygenase induction by lipopolysaccharide, poly(I) · poly(C), and pokeweed mitogen in mouse lung

1986 • 50 citations

Cerebral cortex and lung indoleamine-2,3-dioxygenase activity is increased in type-D retrovirus infected macaques

1991 • 49 citations

Serial pathogenesis study of SIV brain infection

1991 • 48 citations

(18O)quinolinic acid: Its esterification without back exchange for use as internal standard in the quantification of brain and CSF quinolinic acid

1988 • 47 citations

Induction of indoleamine dioxygenase by interferon in mice: A study with different recombinant interferons and various cytokines

1988 • 46 citations

Systemic Lipopolysaccharide and Pokeweed Mitogen Increase Quinolinic Acid Content of Mouse Cerebral Cortex

1988 • 41 citations

4-chloro-3-hydroxyanthranilate inhibits brain 3-hydroxyanthranate oxidase

1988 • 40 citations

Peripheral neuropathy associated with eosinophilia‐myalgia syndrome

1990 • 40 citations

Sustained increases in cerebrospinal fluid quinolinic acid concentrations in rhesus macaques (Macaca mulatta) naturally infected with simian retrovirus type-D

1990 • 32 citations

Cerebrospinal fluid and serum neopterin and biopterin in D-retrovirus-infected rhesus macaques (Macaca mulatta)

1991 • 24 citations

Asymptomatic Infection of the Central Nervous System by the Macaque Immunosuppressive Type D Retrovirus, SRV-1

1989 • 22 citations