Two suppressors ofsel-12encode C2H2zinc-finger proteins that regulate presenilin transcription inCaenorhabditis elegans

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Genomic sequencing.

1984 • 8,343 citations

Alzheimer's Disease: Genes, Proteins, and Therapy

2001 • 5,919 citations

The Nematode Caenorhabditis elegans

1988 • 2,868 citations

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

1999 • 2,051 citations

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

1999 • 1,880 citations

A molecular evolutionary framework for the phylum Nematoda

1998 • 1,851 citations

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1998 • 1,786 citations

Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans

2001 • 1,779 citations

Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans

2000 • 1,277 citations

Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo

1996 • 1,013 citations

aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation

2002 • 795 citations

Nuclear Access and Action of Notch In Vivo

1998 • 730 citations

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1995 • 705 citations

Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi

2001 • 697 citations

Presenilin 1 is linked with γ-secretase activity in the detergent solubilized state

2000 • 526 citations

γ-Secretase, notch, Aβ and alzheimer's disease: Where do the presenilins fit in?

2002 • 505 citations

CoREST is an integral component of the CoREST- human histone deacetylase complex

2001 • 484 citations

Regulation of Histone Acetylation and Transcription by INHAT, a Human Cellular Complex Containing the Set Oncoprotein

2001 • 469 citations

Corepressor-Dependent Silencing of Chromosomal Regions Encoding Neuronal Genes

2002 • 454 citations

Functional Interaction between SEL-10, an F-box Protein, and the Nuclear Form of Activated Notch1 Receptor

2001 • 374 citations

The Presenilin 1 Protein Is a Component of a High Molecular Weight Intracellular Complex That Contains β-Catenin

1998 • 373 citations

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

1996 • 360 citations

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1999 • 358 citations

Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex

2002 • 354 citations

The Proteolytic Fragments of the Alzheimer's Disease-associated Presenilin-1 Form Heterodimers and Occur as a 100–150-kDa Molecular Mass Complex

1998 • 329 citations

Stable Histone Deacetylase Complexes Distinguished by the Presence of SANT Domain Proteins CoREST/kiaa0071 and Mta-L1

2001 • 323 citations

Operons in C. elegans: Polycistronic mRNA precursors are processed by trans-splicing of SL2 to downstream coding regions

1993 • 293 citations

A core–BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes

2002 • 289 citations

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

2000 • 263 citations

Regulation of Interneuron Function in the C. elegans Thermoregulatory Pathway by the ttx-3 LIM Homeobox Gene

1997 • 262 citations

sel-10, a negative regulator of lin-12 activity inCaenorhabditis elegans, encodes a member of the CDC4 family of proteins

1997 • 234 citations

Presenilin and nicastrin regulate each other and determine amyloid β-peptide production via complex formation

2002 • 232 citations

Endoproteolytic Processing and Stabilization of Wild-type and Mutant Presenilin

1997 • 205 citations

Human presenilin‐1, but not familial Alzheimer’s disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing

1997 • 201 citations

LAG-3 is a putative transcriptional activator in the C. elegans Notch pathway

2000 • 190 citations

REST Repression of Neuronal Genes Requires Components of the hSWI·SNF Complex

2002 • 180 citations

Stable Association of Presenilin Derivatives and Absence of Presenilin Interactions with APP

1998 • 177 citations

The Oncoprotein Set/TAF-1β, an Inhibitor of Histone Acetyltransferase, Inhibits Active Demethylation of DNA, Integrating DNA Methylation and Transcriptional Silencing

2002 • 170 citations

Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions.

1992 • 159 citations

Temporal reiteration of a precise gene expression pattern during nematode development.

1996 • 157 citations

HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling

1997 • 155 citations

Presenilin is required for proper morphology and function of neurons in C. elegans

2000 • 106 citations

Notch and Presenilin: a proteolytic mechanism emerges

2001 • 106 citations

The presenilin protein family member SPE-4 localizes to an ER/Golgi derived organelle and is required for proper cytoplasmic partitioning during Caenorhabditis elegans spermatogenesis

1998 • 99 citations

Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel- 12 and hop- 1 in Notch-pathway signaling

1999 • 80 citations

A Local, High-Density, Single-Nucleotide Polymorphism Map Used to Clone Caenorhabditis elegans cdf-1

1999 • 78 citations

Suppressors of the egg-laying defective phenotype of sel-12 presenilin mutants implicate the CoREST corepressor complex in LIN-12/Notch signaling in C. elegans

2002 • 73 citations

SEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in Caenorhabditis elegans

2000 • 67 citations

Loss of spr-5 bypasses the requirement for the C.elegans presenilin sel-12 by derepressing hop-1

2002 • 59 citations

spr-2 , a suppressor of the egg-laying defect caused by loss of sel-12 presenilin in Caenorhabditis elegans , is a member of the SET protein subfamily

2000 • 40 citations

The SEL-12 Presenilin Mediates Induction of the Caenorhabditis elegans Uterine π Cell Fate

2001 • 29 citations

The Caenorhabditis elegans Presenilin sel-12 Is Required for Mesodermal Patterning and Muscle Function

2002 • 16 citations