Apoptosis, nucleosomes, and nephritis in systemic lupus erythematosus

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1992 • 2,932 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.

1994 • 1,722 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 • 1,549 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1991 • 1,185 citations

Protection from Fas-Mediated Apoptosis by a Soluble Form of the Fas Molecule

1994 • 1,120 citations

Phagocyte recognition of cells undergoing apoptosis

1993 • 1,000 citations

Nucleosome Structure

1980 • 923 citations

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.

1991 • 876 citations

Dominance and Crypticity of T Cell Antigenic Determinants

1993 • 838 citations

Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus.

1993 • 637 citations

Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus.

1994 • 555 citations

Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice.

1993 • 506 citations

Necrosis and apoptosis: distinct modes of cell death with fundamentally different significance.

1982 • 500 citations

Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide.

1993 • 410 citations

T cell receptor alpha/beta expressing double-negative (CD4-/CD8-) and CD4+ T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritis.

1989 • 402 citations

Disappearance of the Lymphoid System in Bcl-2 Homozygous Mutant Chimeric Mice

1993 • 402 citations

Programmed cell death, apoptosis and killer genes

1993 • 396 citations

Induction of various autoantibodies by mutant gene lpr in several strains of mice.

1984 • 390 citations

Endogenous circulating DNA in systemic lupus erythematosus. Occurrence as multimeric complexes bound to histone.

1990 • 367 citations

Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells.

1993 • 341 citations

SYSTEMIC LUPUS ERYTHEMATOSUS: PROTOTYPE OF IMMUNE COMPLEX NEPHRITIS IN MAN

1971 • 320 citations

The central role of chromatin in autoimmune responses to histones and DNA in systemic lupus erythematosus.

1994 • 307 citations

Expression of Bcl-2 and Bcl-2-Ig fusion transcripts in normal and neoplastic cells.

1987 • 297 citations

Biophysiology of glomerular filtration and proteinuria.

1984 • 290 citations

Autoimmune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene.

1993 • 287 citations

Anti-nucleosome antibodies complexed to nucleosomal antigens show anti-DNA reactivity and bind to rat glomerular basement membrane in vivo.

1994 • 267 citations

The defect in Fas mRNA expression in MRL/lpr mice is associated with insertion of the retrotransposon, ETn.

1993 • 241 citations

A monoclonal antibody against GBM heparan sulfate induces an acute selective proteinuria in rats

1992 • 237 citations

Genesis and evolution of antichromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen.

1993 • 234 citations

Pathogenic anti-DNA autoantibody-inducing T helper cell lines from patients with active lupus nephritis: isolation of CD4-8- T helper cell lines that express the gamma delta T-cell antigen receptor.

1990 • 205 citations

The apoptosis-1/Fas protein in human systemic lupus erythematosus.

1994 • 200 citations

An intrinsic B cell defect is required for the production of autoantibodies in the lpr model of murine systemic autoimmunity.

1991 • 198 citations

Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways.

1994 • 198 citations

Prevention of nephritis in major histocompatibility complex class II-deficient MRL-lpr mice.

1994 • 194 citations

Antigen-induced apoptosis in developing t cells: a mechanism for negative selection of the t cell receptor repertoire*

1989 • 186 citations

Monoclonal autoantibodies to subnucleosomes from a MRL/Mp(-)+/+ mouse. Oligoclonality of the antibody response and recognition of a determinant composed of histones H2A, H2B, and DNA.

1992 • 174 citations

Current status of the structural and functional basis of glomerular filtration and proteinuria.

1991 • 162 citations

Distribution of GBM heparan sulfate proteoglycan core protein and side chains in human glomerular diseases

1993 • 159 citations

Selection of the T cell receptor repertoire in Lpr mice.

1993 • 155 citations

Histones have high affinity for the glomerular basement membrane. Relevance for immune complex formation in lupus nephritis.

1989 • 151 citations

Comparison of pathogenic and non-pathogenic murine antibodies to DNA: antigen binding and structural characteristics

1994 • 150 citations

Autoimmune gld mutation uncouples suicide and cytokine/proliferation pathways in activated, mature T cells

1993 • 146 citations

Correction of accelerated autoimmune disease by early replacement of the mutated lpr gene with the normal Fas apoptosis gene in the T cells of transgenic MRL-lpr/lpr mice.

1994 • 145 citations

Failure to detect circulating DNA--anti-DNA complexes by four radioimmunological methods in patients with systemic lupus erythematosus.

1977 • 137 citations

Drug-induced anti-histone autoantibodies display two patterns of reactivity with substructures of chromatin.

1991 • 134 citations

Mature CD4+ T lymphocytes from MRL/lpr mice are resistant to receptor-mediated tolerance and apoptosis.

1993 • 125 citations

Association of Antibody to Histone Complex H2A–H2B with Symptomatic Procainamide-Induced Lupus

1988 • 115 citations

The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow.

1993 • 115 citations

Nucleosomes and DNA bind to specific cell-surface molecules on murine cells and induce cytokine production

1992 • 114 citations

CD3‐mediated apoptosis of human medullary thymocytes and activated peripheral T cells: Respective roles of interleukin‐1, interleukin‐2, interferon‐γ and accessory cells

1993 • 113 citations

Immunogenic DNA-related factors. Nucleosomes spontaneously released from normal murine lymphoid cells stimulate proliferation and immunoglobulin synthesis of normal mouse lymphocytes.

1990 • 112 citations

The spontaneous apoptotic cell death of normal human lymphocytes in vitro: The release of, and immunoproliferative response to, nucleosomes in vitro

1991 • 108 citations

Autoantibodies associated with lupus induced by diverse drugs target a similar epitope in the (H2A-H2B)-DNA complex.

1992 • 104 citations

Circulating DNA and lupus nephritis

1988 • 103 citations

Anti-DNA antibodies can bind to the glomerulus via two distinct mechanisms

1992 • 100 citations

Defective mononuclear phagocyte function in systemic lupus erythematosus: dissociation of Fc receptor-ligand binding and internalization.

1984 • 99 citations

Cross-reactions of anti-DNA antibodies and the central dogma of lupus nephritis

1985 • 98 citations

Costimulation with integrin ligands intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 augments activation-induced death of antigen-specific CD4+ T lymphocytes.

1993 • 98 citations

Cross-reactivity of monoclonal anti-DNA antibodies with heparan sulfate is mediated via bound DNA/histone complexes

1990 • 92 citations

A monoclonal anti-double-stranded DNA autoantibody binds to a 94-kDa cell-surface protein on various cell types via nucleosomes or a DNA-histone complex.

1989 • 91 citations

Immunochemistry of DNA

1989 • 76 citations

Accelerated programmed cell death of MRL-lpr/lpr T lymphocytes.

1992 • 71 citations

Differential activation of antigen-stimulated suicide and cytokine production pathways in CD4+ T cells is regulated by the antigen-presenting cell.

1993 • 62 citations

lpr T cells are necessary for autoantibody production in lpr mice.

1993 • 60 citations

Decrease of heparan sulfate staining in the glomerular basement membrane in murine lupus nephritis.

1995 • 47 citations

Death and T Cells

1993 • 44 citations

Glomerular immune deposits in murine lupus models may contain histones

1992 • 44 citations

Production and analysis of IgG monoclonal anti-DNA antibodies from systemic lupus erythematosus (SLE) patients

1993 • 42 citations

Anti-heparan sulphate reactivity in sera from patients with systemic lupus erythematosus with renal or non-renal manifestations

1990 • 39 citations

A role for histones and ubiquitin in lupus nephritis?

1994 • 38 citations

Nucleosome‐specific antibody from an autoimmune mrl/mp‐lpr/lpr mouse

1993 • 36 citations

Higher anti-heparan sulphate reactivity during systemic lupus erythematosus (SLE) disease exacerbations with renal manifestations; a long term prospective analysis

1993 • 35 citations

Systemic lupus erythematosus

1991 • 32 citations

Antibodies to vascular heparan sulfate proteoglycan in patients with systemic lupus Erythematosus

1991 • 29 citations

Anti-double stranded DNA, anti-histone, and anti-nucleosome IgG reactivities in children with systemic lupus erythematosus.

1994 • 28 citations

The origin and pathogenic role of anti-DNA autoantibodies

1990 • 25 citations

Ultrastructural localization of DNA in immune deposits of human lupus nephritis.

1993 • 23 citations

Mononuclear phagocyte system dysfunction in murine SLE: abnormal clearance kinetics precede clinical disease.

1991 • 19 citations

Transcriptional overexpression of the proto-oncogene bcl-2 in patients with systemic Lupus erythematosus.

1992 • 19 citations

Unique phenotype and distinct TCR V beta repertoire in human peripheral blood alpha beta TCR+, CD4-, and CD8- double negative T cells.

1994 • 17 citations

Surface charge distribution is a determinant of antigen deposition in the renal glomerulus: studies employing ‘charge-hybrid’ molecules

1991 • 10 citations

Differential activation of antigen-stimulated suicide and cytokine production pathways in CD4+ T cells is regulated by the antigen-presenting cell

1993 • 4 citations