Cytokine regulation of endothelial cell function: from molecular level to the bedside

Nitric oxide synthases: Roles, tolls, and controls

1994 • 2,945 citations

The Prognostic Value of C-Reactive Protein and Serum Amyloid A Protein in Severe Unstable Angina

1994 • 2,343 citations

Interleukin-8 as a Macrophage-Derived Mediator of Angiogenesis

1992 • 2,130 citations

Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines.

1995 • 1,762 citations

Inhibition of NF-κB by Sodium Salicylate and Aspirin

1994 • 1,743 citations

Transcriptional regulation of endothelial cell adhesion molecules: NF‐κB and cytokine‐inducible enhancers

1995 • 1,715 citations

T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines.

1996 • 1,496 citations

Circulating adhesion molecules in disease

1993 • 1,425 citations

The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor

1995 • 1,311 citations

Cytokines and endothelial cell biology

1990 • 1,275 citations

The Functional Role of the ELR Motif in CXC Chemokine-mediated Angiogenesis

1995 • 1,222 citations

Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells.

1993 • 1,079 citations

Inhibition of Angiogenesis In Vivo by Interleukin 12

1995 • 734 citations

High-dose recombinant tumor necrosis factor alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma.

1992 • 730 citations

Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo.

1995 • 710 citations

Induction and Stabilization of IκBα by Nitric Oxide Mediates Inhibition of NF-κB

1995 • 707 citations

Cytokine regulation of endothelial cell function

1992 • 684 citations

IL-1 stimulates IL-6 production in endothelial cells.

1989 • 541 citations

Endothelial cell binding of NAP-1/IL-8: role in neutrophil emigration

1992 • 477 citations

Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1).

1992 • 476 citations

Nitric Oxide Modulates the Expression of Monocyte Chemoattractant Protein 1 in Cultured Human Endothelial Cells

1995 • 475 citations

The IP-10 chemokine binds to a specific cell surface heparan sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation.

1995 • 456 citations

The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity.

1992 • 446 citations

Activation of cultured vascular endothelial cells by antiphospholipid antibodies.

1995 • 425 citations

Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component.

1992 • 420 citations

NF-kappa B and I kappa B alpha: an inducible regulatory system in endothelial activation.

1994 • 416 citations

Expression of functional CD40 by vascular endothelial cells.

1995 • 414 citations

Tumor necrosis factor alpha (TNF-alpha)-induced cell adhesion to human endothelial cells is under dominant control of one TNF receptor type, TNF-R55.

1993 • 395 citations

The type II ‘decoy’ receptor: A novel regulatory pathway for interleukin 1

1994 • 382 citations

Role of B61, the Ligand for the Eck Receptor Tyrosine Kinase, in TNF-α-Induced Angiogenesis

1995 • 368 citations

Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity.

1994 • 365 citations

ESM-1 Is a Novel Human Endothelial Cell-specific Molecule Expressed in Lung and Regulated by Cytokines

1996 • 359 citations

Induction of Interleukin 6 (IL-6) by Hypoxia in Vascular Cells

1995 • 348 citations

Hypoxic induction of interleukin-8 gene expression in human endothelial cells.

1994 • 346 citations

Cytokine-inducible expression in endothelial cells of an I kappa B alpha-like gene is regulated by NF kappa B.

1993 • 338 citations

Regulation of the production of the RANTES chemokine by endothelial cells. Synergistic induction by IFN-gamma plus TNF-alpha and inhibition by IL-4 and IL-13.

1995 • 318 citations

The Duffy antigen/receptor for chemokines (DARC) is expressed in endothelial cells of Duffy negative individuals who lack the erythrocyte receptor.

1995 • 299 citations

Tumor necrosis factor and interleukin-1 induce expression of the verocytotoxin receptor globotriaosylceramide on human endothelial cells: implications for the pathogenesis of the hemolytic uremic syndrome

1992 • 295 citations

Complement-mediated regulation of tissue factor activity in endothelium.

1995 • 295 citations

Functional interactions of T cells with endothelial cells: the role of CD40L-CD40-mediated signals.

1995 • 280 citations

Regulation of the tissue factor gene

1995 • 275 citations

Inhibition of endothelial cell activation by adenovirus-mediated expression of I kappa B alpha, an inhibitor of the transcription factor NF-kappa B.

1996 • 252 citations

A20 Blocks Endothelial Cell Activation through a NF-κB-dependent Mechanism

1996 • 248 citations

Production of the RANTES chemokine in delayed-type hypersensitivity reactions: involvement of macrophages and endothelial cells.

1994 • 223 citations

IgG antiendothelial cell autoantibodies from scleroderma patients induce leukocyte adhesion to human vascular endothelial cells in vitro. Induction of adhesion molecule expression and involvement of endothelium-derived cytokines.

1996 • 219 citations

Enhancement by the complement membrane attack complex of tumor necrosis factor-alpha-induced endothelial cell expression of E-selectin and ICAM-1.

1995 • 214 citations

Alpha-tocopherol inhibits agonist-induced monocytic cell adhesion to cultured human endothelial cells.

1994 • 213 citations

Endothelial Cell Activation and Thromboregulation during Xenograft Rejection

1994 • 210 citations

Cloning of mouse ptx3, a new member of the pentraxin gene family expressed at extrahepatic sites

1996 • 208 citations

Critical involvement of transmembrane tumor necrosis factor-alpha in endothelial programmed cell death mediated by ionizing radiation and bacterial endotoxin

1995 • 207 citations

Glucocorticoid-mediated Repression of NFκB Activity in Endothelial Cells Does Not Involve Induction of IκBα Synthesis

1996 • 204 citations

Interleukin-1 induces interleukin-8 secretion from endothelial cells by a juxtacrine mechanism

1994 • 204 citations

Selective inhibition of E-selectin, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 expression by inhibitors of I kappa B-alpha phosphorylation.

1995 • 190 citations

Activation of the CPP32 Apoptotic Protease by Distinct Signaling Pathways with Differential Sensitivity to Bcl-xL

1996 • 190 citations

Production of chemokines, interleukin-8 and monocyte chemoattractant protein-1, during monocyte: endothelial cell interactions

1995 • 184 citations

Nitric Oxide Inhibits Macrophage-Colony Stimulating Factor Gene Transcription in Vascular Endothelial Cells

1995 • 180 citations

Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells

1996 • 172 citations

Cytokines from activated T cells induce normal endothelial cells to acquire the phenotypic and functional features of AIDS-Kaposi's sarcoma spindle cells.

1995 • 171 citations

Regulation of the Tissue Factor Promoter in Endothelial Cells

1995 • 160 citations

A critical role for monocytes and CD14 in endotoxin-induced endothelial cell activation.

1993 • 151 citations

Tumor necrosis factor alpha-induced angiogenesis depends on in situ platelet-activating factor biosynthesis.

1994 • 149 citations

Anti‐endothelial cell IgG antibodies from patients with Wegener's granulomatosis bind to human endothelial cells in vitro and induce adhesion molecule expression and cytokine secretion

1996 • 141 citations

IL-6 and IL-8 production from cultured human endothelial cells stimulated by infection with Rickettsia conorii via a cell-associated IL-1 alpha-dependent pathway.

1995 • 140 citations

Interleukin-4 (IL-4) and IL-13 bind to a shared heterodimeric complex on endothelial cells mediating vascular cell adhesion molecule-1 induction in the absence of the common gamma chain

1996 • 140 citations

gro-beta, a -C-X-C- chemokine, is an angiogenesis inhibitor that suppresses the growth of Lewis lung carcinoma in mice.

1995 • 138 citations

Chemokine gene expression and secretion by cytokine-activated human microvascular endothelial cells. Differential regulation of monocyte chemoattractant protein-1 and interleukin-8 in response to interferon-gamma.

1994 • 137 citations

Ryanodine Receptor-Ankyrin Interaction Regulates Internal Ca2+ Release in Mouse T-lymphoma Cells

1995 • 137 citations

Endogenous interleukin 1 alpha must be transported to the nucleus to exert its activity in human endothelial cells.

1994 • 134 citations

IL-8 specifically binds to endothelial but not to smooth muscle cells.

1995 • 129 citations

Cloning of a novel tumor necrosis factor-alpha-inducible primary response gene that is differentially expressed in development and capillary tube-like formation in vitro.

1992 • 129 citations

Intravenous interleukin-8 inhibits granulocyte emigration from rabbit mesenteric venules without altering L-selectin expression or leukocyte rolling.

1993 • 127 citations

Mechanism of the Tumor Necrosis Factor α-mediated Induction of Endothelial Tissue Factor

1995 • 125 citations

Selective interaction of a subset of interferon-gamma response element-binding proteins with the intercellular adhesion molecule-1 (ICAM-1) gene promoter controls the pattern of expression on epithelial cells.

1994 • 122 citations

Sp1 Is a Component of the Cytokine-inducible Enhancer in the Promoter of Vascular Cell Adhesion Molecule-1

1995 • 121 citations

Internalization of Staphylococcus aureus by endothelial cells induces cytokine gene expression

1995 • 119 citations

Disparate localization of 55-kd and 75-kd tumor necrosis factor receptors in human endothelial cells.

1995 • 117 citations

Regulation of endothelial and mesothelial cell function by interleukin- 13: selective induction of vascular cell adhesion molecule-1 and amplification of interleukin-6 production

1994 • 116 citations

IL-8 and angiogenesis: evidence that human endothelial cells lack receptors and do not respond to IL-8 in vitro

1995 • 110 citations

Effects of Transforming Growth Factor β and Interleukin-1β on Expression of Cyclooxygenase 1 and 2 and Phospholipase A2 mRNA in Lung Fibroblasts and Endothelial Cells in Culture

1993 • 109 citations

Identification and Characterization of a Novel Cytokine-inducible Nuclear Protein from Human Endothelial Cells

1995 • 109 citations

IL-4 and IL-13 activate the JAK2 tyrosine kinase and Stat6 in cultured human vascular endothelial cells through a common pathway that does not involve the gamma c chain.

1996 • 109 citations

Functional activities of receptors for tumor necrosis factor-alpha on human vascular endothelial cells

1994 • 106 citations

Selective Elevation of Monocyte Chemotactic Protein-1 in the Cerebrospinal Fluid of AIDS Patients with Cytomegalovirus Encephalitis

1996 • 103 citations

Cyclin-dependent Kinase Site-regulated Signal-dependent Nuclear Localization of the SWI5 Yeast Transcription Factor in Mammalian Cells

1995 • 100 citations

Tissue-specific expression of murine IP-10 mRNA following systemic treatment with interferon γ

1992 • 95 citations

Human cytomegalovirus alters interleukin-6 production by endothelial cells

1994 • 94 citations

Cerebral malaria: Mediators, mechanical obstruction or more?

1994 • 88 citations

Platelet-Activating Factor Produced by Endothelial Cells. A Molecule with Autocrine and Paracrine Properties

1995 • 83 citations

Characterization of a novel tumor necrosis factor-alpha-induced endothelial primary response gene.

1992 • 81 citations

Divergent effects of interleukin‐10 on cytokine production by mononuclear phagocytes and endothelial cells

1993 • 80 citations

Infection of human endothelial cells with Epstein-Barr virus.

1995 • 77 citations

Chemoattractants induce rapid release of the interleukin 1 type II decoy receptor in human polymorphonuclear cells.

1995 • 76 citations

B94, a primary response gene inducible by tumor necrosis factor-alpha, is expressed in developing hematopoietic tissues and the sperm acrosome.

1994 • 69 citations

Tumor necrosis factor alpha induces endothelial galactosyl transferase activity and verocytotoxin receptors. Role of specific tumor necrosis factor receptors and protein kinase C

1995 • 69 citations

Both tumor necrosis factor receptors, TNFR60 and TNFR80, are involved in signaling endothelial tissue factor expression by juxtacrine tumor necrosis factor alpha

1995 • 62 citations

Antigen presentation by human dermal microvascular endothelial cells. Immunoregulatory effect of IFN-gamma and IL-10.

1994 • 60 citations

Interleukin-1 Enhances the Ability of Cultured Human Umbilical Vein Endothelial Cells to Oxidize Linoleic Acid

1995 • 59 citations

Cell Type-specific Transactivation of the VCAM-1 Promoter through an NF-κB Enhancer Motif

1995 • 57 citations

Platelet-Activating Factor Produced by Endothelial Cells. A Molecule with Autocrine and Paracrine Properties

1995 • 56 citations

Pyrrolidine dithiocarbamate abrogates tissue factor (TF) expression by endothelial cells: evidence implicating nuclear factor-kappa B in TF induction by diverse agonists

1995 • 50 citations

Modulation of Human Endothelial Cell Tetrahydrobiopterin Synthesis by Activating and Deactivating Cytokines: New Perspectives on Endothelium-Derived Relaxing Factor

1993 • 49 citations

Inducible expression of type 2 IL-1 receptors by cultured human keratinocytes. Implications for IL-1-mediated processes in epidermis.

1995 • 49 citations

Upregulation of human immunodeficiency virus-1 in chronically infected monocytic cell line by both contact with endothelial cells and cytokines

1994 • 43 citations

Interferon-gamma upregulates interleukin-3 (IL-3) receptor expression in human endothelial cells and synergizes with IL-3 in stimulating major histocompatibility complex class II expression and cytokine production

1995 • 42 citations

Human cytomegalovirus alters interleukin-6 production by endothelial cells

1994 • 39 citations

ATF-a0, a novel variant of the ATF/CREB transcription factor family, forms a dominant transcription inhibitor in ATF-a heterodimers.

1994 • 33 citations

In vitro biosynthesis of leukemia inhibitory factor/human interleukin for DA cells by human endothelial cells: differential regulation by interleukin-1 alpha and glucocorticoids

1995 • 31 citations

Purification and identification of mouse lung microvessel endothelial cell-derived chemoattractant for lung-metastasizing murine RAW117 large-cell lymphoma cells: identification as mouse monocyte chemotactic protein 1.

1995 • 27 citations

Identification of Signal-induced IκB-α Kinases in Human Endothelial Cells

1996 • 25 citations

Actions of Molecules which Regulate Hemopoiesis on Endothelial Cells: Memoirs of Common Ancestors?

1994 • 21 citations

Two distinct NF-χB complexes differing in their larger subunit bind the E-selectin promoter χB element

1993 • 21 citations

Cytokines and Cell Adhesion Molecules in Tumor-Endothelial Cell Interaction and Metastasis

1994 • 18 citations

Interleukin-1 and Tumor Necrosis Factor Induce Transient Expression of an Inhibitor of Nuclear Factor kB in Endothelial Cells

1993 • 7 citations