Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells

Basic local alignment search tool

1990 • 87,358 citations

Basic Local Alignment Search Tool

1990 • 12,947 citations

Culture of Human Endothelial Cells Derived from Umbilical Veins. IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGIC CRITERIA

1973 • 6,904 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

1987 • 5,139 citations

Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

1988 • 4,669 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair

1993 • 1,638 citations

The extracellular matrix as a cell survival factor.

1993 • 1,541 citations

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

1994 • 1,303 citations

BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.

1991 • 1,301 citations

Migration and proliferation of endothelial cells in preformed and newly formed blood vessels during tumor angiogenesis

1977 • 1,286 citations

Cytokines and endothelial cell biology

1990 • 1,275 citations

HMEC-1: Establishment of an Immortalized Human Microvascular Endothelial Cell Line

1992 • 1,258 citations

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

1993 • 1,044 citations

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2.

1993 • 959 citations

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.

1995 • 832 citations

Induction of apoptosis by the Bcl-2 homologue Bak

1995 • 738 citations

An endothelial cell growth factor from bovine hypothalamus: identification and partial characterization.

1979 • 727 citations

Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3′ AU-rich sequences

1988 • 691 citations

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.

1994 • 590 citations

Two distinct destabilizing elements in the c-fos message trigger deadenylation as a first step in rapid mRNA decay.

1991 • 546 citations

Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak

1995 • 514 citations

Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells.

1993 • 465 citations

The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity.

1992 • 446 citations

Developmental mechanisms underlying pathology of arteries

1990 • 445 citations

Tumor necrosis factor induces apoptosis (programmed cell death) in normal endothelial cells in vitro.

1991 • 358 citations

Ultrastructural localization of bcl-2 protein.

1992 • 351 citations

Expression of bcl-2 in fetal tissues suggests a role in morphogenesis.

1993 • 320 citations

Induction of Endothelial Cell Apoptosis by TNFα: Modulation by Inhibitors of Protein Synthesis

1994 • 292 citations

BCL‐2 expression in adult and embryonic non‐haematopoietic tissues

1993 • 265 citations

Apoptosis of vascular endothelial cells by fibroblast growth factor deprivation

1990 • 230 citations

bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine.

1995 • 227 citations

The protein bcl-2 alpha does not require membrane attachment, but two conserved domains to suppress apoptosis.

1994 • 186 citations

A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow.

1995 • 147 citations

Cloning and molecular characterization of mouse bcl-x in B and T lymphocytes.

1994 • 133 citations

Role of protein kinase C in the inhibition by fibroblast growth factor of apoptosis in serum-depleted endothelial cells

1990 • 119 citations

Human endothelial cell response to lipopolysaccharide, interleukin-1, and tumor necrosis factor is regulated by protein synthesis

1989 • 112 citations

Novel expression pattern of a new member of the MIP-1 family of cytokine-like genes.

1991 • 76 citations

bcl-2 Gene Prevents Apoptosis of Basic Fibroblast Growth Factor-Deprived Murine Aortic Endothelial Cells

1994 • 63 citations

Arteriolar structure and its implication for function in health and disease

1994 • 10 citations