Decreased frequency of interferon‐γ‐ producing CD4⁺ cells in the peripheral blood of patients with atopic dermatitis

Diagnostic Features of Atopic Dermatitis

1980 • 4,910 citations

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells.

1991 • 1,880 citations

Detection of intracellular cytokines by flow cytometry

1993 • 992 citations

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.

1991 • 976 citations

IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2.

1988 • 939 citations

Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines.

1991 • 835 citations

Assessment of Cytokines by Immunofluorescence and the Paraformaldehyde‐Saponin Procedure

1991 • 465 citations

Grading of the severity of atopic dermatitis.

1989 • 419 citations

Biology of human TH1 and TH2 cells

1995 • 408 citations

In vivo expression of IL-12 and IL-13 in atopic dermatitis

1996 • 380 citations

Decreased interferon gamma and increased interleukin-4 production in atopic dermatitis promotes IgE synthesis

1992 • 277 citations

Overexpression of IL-10 in atopic dermatitis. Contrasting cytokine patterns with delayed-type hypersensitivity reactions.

1995 • 274 citations

Human atopen-specific types 1 and 2 T helper cell clones.

1991 • 273 citations

Shifts in interleukin-4 and interferon-γ production by T cells of patients with elevated serum IgE levels and the modulatory effects of these lymphokines on spontaneous IgE synthesis

1991 • 224 citations

IL-4 and interferon-gamma production in children with atopic disease

1993 • 168 citations

Evidence that defective interferon-gamma production in dermatitis patients is due to intrinsic abnormalities

1990 • 137 citations

Altered prostaglandin E2 regulation of cytokine production in atopic dermatitis.

1993 • 133 citations

Decreased frequency of interferon-γ– and interleukin-2–producing cells in patients with atopic diseases measured at the single cell level

1995 • 109 citations

Predominance of type 2 cytokine–producing CD4+ and CD8+ cells in patients with atopic dermatitis

1997 • 101 citations

Down-regulating effects of IL-4 and IL-10 on the IFN-gamma response in atopic dermatitis.

1995 • 96 citations

Frequency analysis of IgE-secreting B lymphocytes in persons with normal or elevated serum IgE levels.

1991 • 74 citations

No relationship between skin-infiltrating T-like cells and allergen-specific IgE response in atopic dermatitis

1995 • 29 citations

Antigen presenting cell-independent cytokine and spontaneous in vitro IgE production in patients with atopic dermatitis: Increased interferon-γ production and lack of effects of in vivo low-dose interferon-γ treatment

1995 • 26 citations