Decreased frequency of interferon-γ– and interleukin-2–producing cells in patients with atopic diseases measured at the single cell level

Rapid colorimetric assay for cell growth and survival

1986 • 4,672 citations

Predominant T_H2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma

1992 • 2,802 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.

1993 • 1,084 citations

Detection of intracellular cytokines by flow cytometry

1993 • 992 citations

Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones.

1992 • 697 citations

Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects.

1991 • 676 citations

Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production.

1991 • 641 citations

Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

1994 • 630 citations

Cytokine messenger RNA expression for IL-3, IL-4, IL-5, and granulocyte/macrophage-colony-stimulating factor in the nasal mucosa after local allergen provocation: relationship to tissue eosinophilia.

1992 • 572 citations

Reduced interferon-γ secretion in neonates and subsequent atopy

1994 • 434 citations

Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory.

1991 • 406 citations

House dust mite-specific T cells in the skin of subjects with atopic dermatitis: Frequency and lymphokine profile in the allergen patch test

1992 • 278 citations

Decreased interferon gamma and increased interleukin-4 production in atopic dermatitis promotes IgE synthesis

1992 • 277 citations

Human atopen-specific types 1 and 2 T helper cell clones.

1991 • 273 citations

Heterogeneity of Bronchial Asthma

1981 • 232 citations

Shifts in interleukin-4 and interferon-γ production by T cells of patients with elevated serum IgE levels and the modulatory effects of these lymphokines on spontaneous IgE synthesis

1991 • 224 citations

Profiles of lymphokine activities and helper function for IgE in human T cell clones

1988 • 204 citations

IL-4 and interferon-gamma production in children with atopic disease

1993 • 168 citations

Simultaneous production of interleukin 2, interleukin 4 and interferon‐γ by activated human blood lymphocytes

1990 • 165 citations

Bone metabolism in children with asthmatreated with inhaled beclomethasone dipropionate

1993 • 152 citations

Enhanced IL-4 Production and IL-4 Receptor Expression in Atopic Dermatitis and Their Modulation by Interferon-Gamma

1992 • 151 citations

Growth and Pituitary-Adrenal Function in Children with Severe Asthma Treated with Inhaled Budesonide

1993 • 149 citations

Scoring atopic dermatitis: the simpler the better?

1989 • 138 citations

Evidence that defective interferon-gamma production in dermatitis patients is due to intrinsic abnormalities

1990 • 137 citations

Functional analysis of human T cell subsets defined by CD45 isoform expression.

1992 • 89 citations

Immunoregulatory abnormalities in atopic dermatitis

1986 • 86 citations

Internalization, lysosomal degradation and new synthesis of surface membrane CD4 in phorbol ester-activated T-lymphocytes and U-937 cells

1992 • 85 citations

A Role for CD4⁺ T‐Cell Subsets Producing a Selective Pattern of Lymphokines in the Pathogenesis of Human Chronic Inflammatory and Allergic Diseases

1991 • 64 citations

Systemic effects of high dose inhaled steroids: comparison of beclomethasone dipropionate and budesonide in healthy subjects.

1993 • 63 citations

Interleukin 2 induces the expression of CD45RO and the memory phenotype by CD45RA+ peripheral blood lymphocytes.

1994 • 61 citations

Basic and clinical aspects of atopic dermatitis.

1984 • 50 citations

Polymerase chain reaction quantification of cytokine messenger RNA expression in peripheral blood mononuclear cells of patients with acute exacerbations of asthma: effect of glucocorticoid therapy

1994 • 48 citations

Human CD4⁺CD45RO⁺ and CD4⁺CD45RA⁺ T cells synergize in response to alloantigens

1991 • 41 citations

Monoclonal antibodies directed to different epitopes in the CD3-TCR complex induce different states of competence in resting human T cells.

1992 • 40 citations

Imbalance of CD4 + CD45R+ and CD4+ CD29+ T helper cell subsets in patients with atopic diseases

1991 • 30 citations

The immunologic basis of atopic dermatitis.

1993 • 24 citations

Altered Leukocyte Protein Kinase Activity in Atopic Dermatitis

1988 • 23 citations

T cell receptor γδ bearing cells are decreased in the peripheral blood of patients with atopic diseases

1991 • 21 citations

Pokeweed mitogen induces IgE synthesis in the presence of a blocking antibody to the interferon-γ receptor

1993 • 14 citations

Imbalance of CD4+CD29+ and CD4+CD45RA+ T-helper cell subsets in peripheral blood of patients with severe atopic dermatitis

1993 • 9 citations

METABOLIC CONSEQUENCES OF HIGH DOSE OH TREATMENT

1993 • 8 citations

Both naive and memory T cells can provide help for human IgE production, but with different cytokine requirements.

1992 • 7 citations

Defect of CD2- and CD3-mediated activation pathways in T cells of atopic patients: Role of interleukin 2

1992 • 6 citations