Predominance of type 2 cytokine–producing CD4+ and CD8+ cells in patients with atopic dermatitis

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Diagnostic Features of Atopic Dermatitis

1980 • 4,910 citations

IL-4 directs the development of Th2-like helper effectors.

1990 • 1,261 citations

Heterogeneity of Cytokine Secretion Patterns and Functions of Helper T Cells

1989 • 1,122 citations

Differing Lymphokine Profiles of Functional Subsets of Human CD4 and CD8 T Cell Clones

1991 • 1,027 citations

Detection of intracellular cytokines by flow cytometry

1993 • 992 citations

Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis.

1994 • 780 citations

IL-4 is an essential factor for the IgE synthesis induced in vitro by human T cell clones and their supernatants.

1988 • 713 citations

Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production.

1991 • 705 citations

Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines

1995 • 686 citations

Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles.

1994 • 527 citations

Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones.

1988 • 509 citations

Grading of the severity of atopic dermatitis.

1989 • 419 citations

Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to IgE production.

1990 • 353 citations

Switch of CD8 T Cells to Noncytolytic CD8 ^- CD4 ^- Cells that Make T _H 2 Cytokines and Help B Cells

1993 • 343 citations

Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens.

1989 • 331 citations

Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones

1991 • 287 citations

Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype.

1994 • 282 citations

Selection of a human T helper type 1-like T cell subset by mycobacteria.

1991 • 281 citations

Decreased interferon gamma and increased interleukin-4 production in atopic dermatitis promotes IgE synthesis

1992 • 277 citations

Th2-like CD8+ T cells showing B cell helper function and reduced cytolytic activity in human immunodeficiency virus type 1 infection.

1994 • 276 citations

Age-related serum immunoglobulin E levels in healthy subjects and in patients with allergic disease

1980 • 269 citations

Alloreactive murine CD8+ T cell clones secrete the Th1 pattern of cytokines.

1990 • 240 citations

Shifts in interleukin-4 and interferon-γ production by T cells of patients with elevated serum IgE levels and the modulatory effects of these lymphokines on spontaneous IgE synthesis

1991 • 224 citations

CD8+ T cells can be primed in vitro to produce IL-4.

1992 • 214 citations

IL-4 and interferon-gamma production in children with atopic disease

1993 • 168 citations

IgE secretion by Epstein-Barr virus-infected purified human B lymphocytes is stimulated by interleukin 4 and suppressed by interferon gamma.

1989 • 167 citations

Enhanced IL-4 Production and IL-4 Receptor Expression in Atopic Dermatitis and Their Modulation by Interferon-Gamma

1992 • 151 citations

Alloreactive cloned T cell lines. VI. Multiple lymphokine activities secreted by helper and cytolytic cloned T lymphocytes.

1982 • 145 citations

Evidence that defective interferon-gamma production in dermatitis patients is due to intrinsic abnormalities

1990 • 137 citations

Atopic disease and serum immunoglobulin-E

2006 • 132 citations

Specific IgE antibodies in atopic eczema

1975 • 122 citations

Decreased frequency of interferon-γ– and interleukin-2–producing cells in patients with atopic diseases measured at the single cell level

1995 • 109 citations

Regulation of IgE synthesis in humans

1992 • 89 citations

Enumeration of IFN-γ-producing cells by flow cytometry

1988 • 64 citations

Frequent coexpression of cytolytic activity and lymphokine production among human T lymphocytes. Production of B cell growth factor and interleukin 2 by T8⁺ and T4⁺ cytolytic clones

1984 • 40 citations

Novel Fundamental Approaches to Intervening in IgE-Mediated Allergic Diseases

1994 • 33 citations

Detection of Individual Interleukin 4‐ and Gamma Interferon‐Producing Murine Spleen Cells after Activation with T‐Cell Mitogens

1989 • 20 citations