Differential effects of interleukin-2 and interleukin-4 on protein tyrosine phosphorylation in factor-dependent murine T cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

High resolution two-dimensional electrophoresis of proteins.

1975 • 19,515 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.

1987 • 1,627 citations

The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1

1985 • 1,590 citations

[42] Detection and quantification of phosphotyrosine in proteins

1983 • 1,184 citations

Identification of a T cell-derived b cell growth factor distinct from interleukin 2.

1982 • 1,095 citations

Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

1984 • 858 citations

Growth of factor-dependent hemopoietic precursor cell lines.

1980 • 793 citations

Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores.

1985 • 742 citations

Response of resting human peripheral blood natural killer cells to interleukin 2.

1984 • 616 citations

Continuous proliferation of murine antigen-specific helper T lymphocytes in culture.

1979 • 522 citations

The interleukin 2 receptor. Functional consequences of its bimolecular structure.

1987 • 409 citations

Interleukin-2 stimulates association of protein kinase C with plasma membrane

1985 • 384 citations

Activated B cells express receptors for, and proliferate in response to, pure interleukin 2.

1984 • 361 citations

Cloning, sequence and expression of human interleukin-2 receptor

1984 • 272 citations

Altered phosphorylation and activation of PP60c-src during fibroblast mitosis

1988 • 249 citations

Expression of high affinity receptors for murine interleukin 4 (BSF-1) on hemopoietic and nonhemopoietic cells.

1988 • 244 citations

Signal Transduction Through the EGF Receptor Transfected in IL-3-Dependent Hematopoietic Cells

1988 • 238 citations

Internalization of interleukin 2 is mediated by the beta chain of the high-affinity interleukin 2 receptor.

1987 • 234 citations

Molecular analysis of signal transduction by growth factors

1988 • 224 citations

PHOSPHATIDYLINOSITOL TURNOVER IN RECEPTOR MECHANISM AND SIGNAL TRANSDUCTION

1985 • 207 citations

Phosphotyrosine-containing proteins isolated by affinity chromatography with antibodies to a synthetic hapten

1981 • 203 citations

T‐Lymphocyte Activation: The Role of Protein Kinase C and the Bifurcating Inositol Phospholipid Signal Transduction Pathway

1987 • 203 citations

Characterization and use of monoclonal antibodies for isolation of phosphotyrosyl proteins from retrovirus-transformed cells and growth factor-stimulated cells.

1983 • 200 citations

Protein kinase C is required for responses to T cell receptor ligands but not to interleukin-2 in T cells

1988 • 183 citations

Oncogenes and growth control

1985 • 180 citations

Phenotypic characteristics of cell lines requiring interleukin 3 for growth.

1982 • 158 citations

Transmembrane Ion Fluxes during Activation of Human T Lymphocytes: Role of Ca²⁺, Na⁺/H⁺ Exchange and Phospholipid Turnover

1987 • 154 citations

Activation of a tyrosine protein kinase is an early event in the stimulation of T lymphocytes by interleukin-2.

1988 • 152 citations

Interleukin-2 induces proliferation of T lymphocyte mutants lacking protein kinase C

1988 • 137 citations

Stimulation of factor-dependent myeloid cell lines with interleukin 3 induces tyrosine phosphorylation of several cellular substrates.

1988 • 117 citations

Lymphocyte activation provokes modification of a lymphocyte-specific protein tyrosine kinase (p56lck).

1989 • 112 citations

Interleukin 2 does not induce phosphatidylinositol hydrolysis in activated T cells.

1986 • 102 citations

Specialized protein tyrosine kinase proto-oncogenes in hematopoietic cells

1989 • 99 citations

Leukocytes express a novel gene encoding a putative transmembrane protein-kinase devoid of an extracellular domain

1988 • 83 citations

A new possible regulatory system for protein phosphorylation in human peripheral lymphocytes. II. Possible relation to phosphatidylinositol turnover induced by mitogens.

1981 • 59 citations

Interactions between receptors for interleukin 2 and interleukin 4 on lines of helper T cells (HT-2) and B lymphoma cells (BCL1).

1989 • 56 citations

Co-internalization of the p55 and p70 subunits of the high-affinity human interleukin 2 receptor. Evidence for a stable ternary receptor complex.

1988 • 35 citations

Characterization of interleukin 2-stimulated phosphorylation of 67 and 63 kDa proteins in human T-cells

1987 • 34 citations

Interleukin-2 induces rapid phosphorylation of an 85 kilodalton protein in permeabilized lymphocytes

1985 • 33 citations

The role of protein kinase C in T lymphocyte proliferation. Existence of protein kinase C-dependent and -independent pathways.

1988 • 30 citations

Protein kinase C-dependent and -independent mechanisms of cloned murine T cell proliferation. The role of protein kinase C translocation and protein kinase C activity.

1989 • 28 citations

The role of protein kinase C in early activation vs. growth of T lymphocytes

1988 • 24 citations

Does interleukin 2 stimulus-response coupling result in generation of intracellular second messengers?

1988 • 19 citations

Bioassay of interleukins

1986 • 17 citations

Interleukin-2 stimulus-response coupling is calcium independent.

1987 • 12 citations