Idiotypic antibody immunotherapy of cancer

Towards a network theory of the immune system.

1974 • 3,379 citations

Induction of Immune Responses in Patients with B-Cell Lymphoma against the Surface-Immunoglobulin Idiotype Expressed by Their Tumors

1992 • 551 citations

Human anti-murine immunoglobulin responses in patients receiving monoclonal antibody therapy.

1985 • 486 citations

Implications of the presence of an internal image of the antigen in anti-idiotypic antibodies: Possible application to vaccine production

1981 • 296 citations

Neonatal administration of idiotype or antiidiotype primes for protection against Escherichia coli K13 infection in mice.

1984 • 265 citations

Human high molecular weight melanoma-associated antigen (HMW-MAA) mimicry by mouse anti-idiotypic monoclonal antibody MK2-23: induction of humoral anti-HMW-MAA immunity and prolongation of survival in patients with stage IV melanoma.

1992 • 261 citations

Three-dimensional structure of an idiotope–anti-idiotope complex

1990 • 227 citations

Surfactants in Severe Hyaline-Membrane Disease - Reply

1978 • 219 citations

Anti-idiotype immunization of cancer patients: modulation of the immune response.

1987 • 190 citations

Immunization of mice against African trypanosomiasis using anti-idiotypic antibodies.

1982 • 188 citations

Idiotope‐specific T cell clones that recognize syngeneic immunoglobulin fragments in the context of class II molecules

1986 • 178 citations

Characterization of cell surface antigens of human mammary epithelial cells with monoclonal antibodies prepared against human milk fat globule

1983 • 178 citations

An anti-idiotype vaccine against experimental schistosomiasis

1985 • 174 citations

Monoclonal Idiotope Vaccine Against Streptococcus pneumoniae Infection

1984 • 172 citations

Three-Dimensional Structure of an Angiotensin II-Fab Complex at 3 Å: Hormone Recognition by an Anti-Idiotypic Antibody

1992 • 162 citations

Nucleic acid sequence of an internal image-bearing monoclonal anti-idiotype and its comparison to the sequence of the external antigen.

1986 • 161 citations

Anti-idiotypic Antibody Vaccine for Type B Viral Hepatitis in Chimpanzees

1986 • 154 citations

Syngeneic monoclonal antiidiotype can induce cellular immunity to reovirus.

1984 • 144 citations

Antimetastatic vaccination of tumor-bearing mice with two types of IFN-gamma gene-inserted tumor cells.

1993 • 142 citations

Active specific immunotherapy in patients with melanoma. A clinical trial with mouse antiidiotypic monoclonal antibodies elicited with syngeneic anti-high-molecular-weight-melanoma-associated antigen monoclonal antibodies.

1990 • 133 citations

Induction of neutralizing antibody in mice against poliovirus type II with monoclonal anti-idiotypic antibody.

1985 • 128 citations

Anti-Idiotypic Antibodies Bear the Internal Image of a Human Tumor Antigen

1986 • 126 citations

Human Tumor Antigens

1987 • 126 citations

Melanoma Antigens: Immunological and Biological Characterization and Clinical Significance

1988 • 116 citations

Immunotherapy of established murine B cell lymphoma. Combination of idiotype immunization and cyclophosphamide.

1988 • 95 citations

IDIOTYPIC NETWORKS AND THEIR POSSIBLE EXPLOITATION FOR MANIPULATION OF THE IMMUNE RESPONSE

1981 • 94 citations

Murine monoclonal anti-idiotype antibody as a potential network antigen for human carcinoembryonic antigen.

1990 • 91 citations

Sendai virus-specific T-cell clones: induction of cytolytic T cells by an anti-idiotypic antibody directed against a helper T-cell clone.

1984 • 87 citations

Induction of an anti-hepatitis B surface antigen response in mice by noninternal image (Ab2 alpha) anti-idiotypic antibodies.

1987 • 85 citations

Suppression of in vivo tumor formation induced by simian virus 40-transformed cells in mice receiving antiidiotypic antibodies.

1985 • 75 citations

Idiotype restriction in murine lupus; high frequency of three public idiotypes on serum IgG in nephritic NZB/NZW F1 mice.

1987 • 68 citations

Antitumor immune response and interleukin 2 production induced in colorectal cancer patients by immunization with human monoclonal anti-idiotypic antibody.

1991 • 65 citations

Revised immune network concepts

1989 • 62 citations

Recognition of Angiotensin II: Antibodies at Different Levels of an Idiotypic Network Are Superimposable

1992 • 56 citations

Idiotype vaccines against human T cell acute lymphoblastic leukemia. I. Generation and characterization of biologically active monoclonal anti-idiotopes.

1987 • 55 citations

Tumor idiotype vaccines. VII. Analysis and correlation of structural, idiotypic, and biologic properties of protective and nonprotective Ab2.

1990 • 54 citations

Anti-idiotype cancer vaccines: pre-clinical and clinical studies.

1991 • 47 citations

Immunotherapy of murine sarcomas with auto-anti-idiotypic monoclonal antibodies which bind to tumor-specific T cells.

1987 • 46 citations

Idiotype vaccines against human T cell leukemia. II. Generation and characterization of a monoclonal idiotype cascade (Ab1, Ab2, and Ab3).

1988 • 44 citations

Tumor-specific idiotype vaccines. III. Induction of T helper cells by anti-idiotype and tumor cells.

1987 • 39 citations

A carcinoembryonic antigen (CEA) specific monoclonal hybridoma antibody that reacts only with high-molecular-weight CEA

1980 • 39 citations

Idiotope antigens (Ab2 alpha and Ab2 beta) can induce in vitro B cell proliferation and antibody production.

1986 • 38 citations

Analysis of the idiotypic network in tumor immunity.

1987 • 33 citations

Murine monoclonal anti-idiotope antibody breaks unresponsiveness and induces a specific antibody response to human melanoma-associated proteoglycan antigen in cynomolgus monkeys.

1992 • 33 citations

Characterization of "regulatory" idiotope-specific T cell clones to a monoclonal anti-idiotypic antibody mimicking a tumor-associated antigen (TAA).

1989 • 32 citations

Monoclonal antibody SN2 defining a human T cell leukemia-associated cell surface glycoprotein.

1984 • 26 citations

Tumor idiotype vaccines. VI. Synergistic anti-tumor effects with combined "internal image" anti-idiotypes and chemotherapy.

1989 • 25 citations

Idiotypic replica of an anti-human tumor-associated antigen monoclonal antibody. Analysis of monoclonal Ab1 and Ab3 fine specificity.

1989 • 22 citations

Anti-Idiotype Antibodies as Potential Therapeutic Agents for Human Breast Cancer

1994 • 15 citations

Monoclonal and anti-idiotypic antibodies as probes for receptor structure and function.

1984 • 11 citations

Idiotype matching: correlation of expression of protective idiotype in sera with survival of tumor mice.

1990 • 11 citations

A "network antigen" for human CD4. A murine monoclonal anti-idiotype to Leu-3a induces an anti-CD4 response in naive mice.

1992 • 9 citations

Potential role of anti-idiotype antibodies in active tumor immunotherapy

1989 • 8 citations