Mechanism of myocardial "stunning".

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

Oxygen toxicity, oxygen radicals, transition metals and disease

1984 • 5,301 citations

Protein damage and degradation by oxygen radicals. I. general aspects.

1987 • 1,618 citations

Direct measurement of free radical generation following reperfusion of ischemic myocardium.

1987 • 1,185 citations

Regional myocardial functional and electrophysiological alterations after brief coronary artery occlusion in conscious dogs.

1975 • 1,004 citations

Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone.

1988 • 691 citations

Measurement of superoxide-derived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury.

1988 • 629 citations

The sodium/hydrogen exchange system in cardiac cells: Its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH

1985 • 612 citations

The oxygen paradox and the calcium paradox: Two facets of the same problem?

1978 • 491 citations

Direct evidence that oxygen-derived free radicals contribute to postischemic myocardial dysfunction in the intact dog.

1989 • 467 citations

Pathophysiology and pathogenesis of stunned myocardium. Depressed Ca2+ activation of contraction as a consequence of reperfusion-induced cellular calcium overload in ferret hearts.

1987 • 424 citations

Prolonged depletion of ATP and of the adenine nucleotide pool due to delayed resynthesis of adenine nucleotides following reversible myocardial ischemic injury in dogs

1981 • 359 citations

Superoxide dismutase plus catalase enhances the efficacy of hypothermic cardioplegia to protect the globally ischemic, reperfused heart

1982 • 355 citations

Significance of xanthine oxidase in capillary endothelial cells.

1986 • 333 citations

Time course of functional and biochemical recovery of myocardium salvaged by reperfusion

1983 • 325 citations

Prevention of granulocyte-mediated oxidant lung injury in rats by a hydroxyl radical scavenger, dimethylthiourea.

1984 • 322 citations

Leukocytes and Ischemia-Induced Myocardial Injury

1986 • 321 citations

Free radicals and myocardial ischemia and reperfusion injury.

1987 • 307 citations

Reversal of dysfunction in postischemic stunned myocardium by epinephrine and postextrasystolic potentiation

1986 • 279 citations

Prolonged derangements of canine myocardial purine metabolism after a brief coronary artery occlusion not associated with anatomic evidence of necrosis

1980 • 257 citations

Profound structural alterations of the extracellular collagen matrix in postischemic dysfunctional (“stunned”) but viable myocardium

1987 • 244 citations

Redox modification of sodium-calcium exchange activity in cardiac sarcolemmal vesicles.

1986 • 242 citations

The oxygen free radical system: A fundamental mechanism in the production of myocardial necrosis

1986 • 236 citations

Intracellular free calcium concentration measured with 19F NMR spectroscopy in intact ferret hearts.

1987 • 225 citations

Energy metabolism in reperfused heart muscle: Metabolic correlates to return of function

1985 • 221 citations

Beta-adrenergic stimulation reverses postischemic myocardial dysfunction without producing subsequent functional deterioration

1985 • 215 citations

Myocardial consequences of reperfusion

1987 • 212 citations

Response of reperfusion-salvaged, stunned myocardium to inotropic stimulation

1984 • 210 citations

Inhibition of surgically induced ischemia/reperfusion injury by oxygen free radical scavengers

1983 • 207 citations

Spin-trapping evidence that graded myocardial ischemia alters post-ischemic superoxide production

1987 • 205 citations

Excitation-contraction coupling in postischemic myocardium. Does failure of activator Ca2+ transients underlie stunning?

1990 • 204 citations

Myocardial ischemia and reperfusion: direct evidence for free radical generation by electron spin resonance spectroscopy.

1988 • 200 citations

Acidosis during early reperfusion prevents myocardial stunning in perfused ferret hearts.

1988 • 200 citations

Coronary arterial reperfusion. III. Early and late effects on regional myocardial function and dimensions in conscious dogs

1976 • 183 citations

Characterization of cardiac sarcoplasmic reticulum dysfunction during short-term, normothermic, global ischemia.

1984 • 171 citations

Effect of verapamil on postischemic “stunned” myocardium: Importance of the timing of treatment

1988 • 160 citations

Cytosolic calcium transients from the beating mammalian heart.

1987 • 159 citations

Conjugated dienes in ischemic and reperfused myocardium: an in vivo chemical signature of oxygen free radical mediated injury

1987 • 152 citations

Persistence of regional left ventricular dysfunction after exercise-induced myocardial ischemia.

1986 • 150 citations

Persistence of myocardial injury following brief periods of coronary occlusion

1976 • 146 citations

Effects of exogenous free radicals on electromechanical function and metabolism in isolated rabbit and guinea pig ventricle. Implications for ischemia and reperfusion injury.

1989 • 140 citations

Effects of supplementing hypothermic crystalloid cardioplegic solution with catalase, superoxide dismutase, allopurinol, or deferoxamine on functional recovery of globally ischemic and reperfused isolated hearts

1986 • 139 citations

Prolonged abnormalities of left ventricular diastolic wall thinning in the “stunned” myocardium in conscious dogs: Time course and relation to systolic function

1989 • 134 citations

Postischemic Myocardial "Stunning": A Clinically Relevant Phenomenon

1988 • 133 citations

The activity of xanthine oxidase in heart of pigs, guinea pigs, rabbits, rats, and humans

1987 • 133 citations

Calcium and its role in myocardial cell injury during ischemia and reperfusion.

1989 • 132 citations

Calcium uptake during post-ischemic reperfusion in the isolated rat heart: Influence of extracellular sodium

1982 • 127 citations

Inotropic stimulation of reperfused myocardium with dopamine: Effects on infarct size and myocardial function

1985 • 124 citations

Preserved high energy phosphate metabolic reserve in globally “stunned” hearts despite reduction of basal ATP content and contractility+

1987 • 118 citations

N-2-Mercaptopropionylglycine improves recovery of myocardial function after reversible regional ischemia

1986 • 115 citations

Perfusate sodium during ischemia modifies post-ischemic functional and metabolic recovery in the rabbit heart*

1984 • 109 citations

Effects of repeated brief coronary occlusion on regional left ventricular function and dimension in dogs

1985 • 107 citations

Nifedipine administered after reperfusion ablates systolic contractile dysfunction of postischemic “stunned” myocardium

1989 • 98 citations

Regional myocardial blood flow, function and metabolism using phosphorus-31 nuclear magnetic resonance spectroscopy during ischemia and reperfusion in dogs

1987 • 97 citations

Effect of adenosine and AICAR on ATP content and regional contractile function in reperfused canine myocardium

1985 • 96 citations

Influence of oxygen radicals generated by xanthine oxidase in the isolated perfused rat heart

1986 • 90 citations

Improved Recovery of Myocardial Segment Function Following a Short Coronary Occlusion in Dogs by Nicorandil, a Potential New Antianginal Agent, and Nifedipine

1985 • 88 citations

Reduction of sympathetic inotropic response after ischemia in dogs. Contributor to stunned myocardium.

1985 • 83 citations

Use of Spin Traps in Intact Animals Undergoing Myocardial Ischemia/Reperfusion: A New Approach to Assessing the Role of Oxygen Radicals in Myocardial “Stunning”

1990 • 76 citations

A comparative study of free radical scavengers in cardioplegic solutions. Improved protection with peroxidase.

1986 • 75 citations

Time course of recovery of “stunned” myocardium following variable periods of ischemia in conscious and anesthetized dogs

1987 • 75 citations

Oxygen toxicity in Streptococcus sanguis. The relative importance of superoxide and hydroxyl radicals.

1982 • 74 citations

Myocardial dysfunction and ultrastructural alterations mediated by oxygen metabolites

1988 • 64 citations

Effect of superoxide dismutase and catalase, given separately, on myocardial "stunning"

1990 • 63 citations

Urate production by human heart

1989 • 62 citations

Absence of detectable xanthine oxidase in human myocardium

1989 • 61 citations

Neutrophil depletion does not prevent myocardial dysfunction after brief coronary occlusion

1989 • 56 citations

Protection by superoxide dismutase and catalase in the isolated rat heart reperfused after prolonged cardioplegia: a combined study of metabolic, functional, and morphometric ultrastructural variables

1987 • 54 citations

Differential enhancement of postischemic segmental systolic thickening by diltiazem

1990 • 53 citations

Recruitment of inotropic reserve in “stunned” myocardium by the cardiotonic agent AR-L 57

1988 • 46 citations

Myocardial stunning in dogs: Preconditioning effect and influence of coronary collateral flow

1990 • 43 citations

Free radical scavengers improve functional recovery of stunned myocardium in a model of surgical coronary revascularization.

1987 • 43 citations

In vivo infusion of oxygen free radical substrates causes myocardial systolic, but not diastolic dysfunction

1990 • 41 citations

Effects of Hydrogen Peroxide on Cardiac Function and Post-Ischaemic Functional Recovery in the Isolated ‘Working’ Rat Heart

1982 • 34 citations

Dissociation between early recovery of regional function and purine nucleotide content in postischaemic myocardium in the conscious dog

1987 • 31 citations

Oxygen radicals in cardiac surgery

1988 • 26 citations

Altered response of reperfused myocardium to repeated coronary occlusion in dogs

1987 • 25 citations

Lipoxygenase inhibitor nafazatrom fails to attenuate postischaemic ventricular dysfunction

1987 • 23 citations

Effect of Intracoronary Superoxide Dismutase on Regional Function in Stunned Myocardium

1989 • 22 citations

Improvement of Postischemic, Contractile Function by the Calcium Channel Blocking Agent Nitrendipine in Conscious Dogs

1988 • 17 citations

Do neutrophils mediate the phenomenon of stunned myocardium?

1989 • 13 citations

Deleted Work

1955 • 0 citations