Effects of supplementing hypothermic crystalloid cardioplegic solution with catalase, superoxide dismutase, allopurinol, or deferoxamine on functional recovery of globally ischemic and reperfused isolated hearts

Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase

1974 • 9,660 citations

Superoxide radicals in feline intestinal ischemia

1981 • 1,213 citations

The Reduction of Cytochrome c by Milk Xanthine Oxidase

1968 • 1,201 citations

Canine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase.

1984 • 915 citations

Xanthine oxidase as a source of free radical damage in myocardial ischemia

1985 • 678 citations

Inhibition of the iron-catalysed formation of hydroxyl radicals from superoxide and of lipid peroxidation by desferrioxamine

1979 • 637 citations

Role of oxygen in the cellular damage induced by re-oxygenation of hypoxic heart

1980 • 550 citations

Do Mitochondria Produce Oxygen Radicals in vivo?

1978 • 530 citations

The role of lipid peroxidation in pathogenesis of ischemic damage and the antioxidant protection of the heart

1982 • 523 citations

The oxygen paradox and the calcium paradox: Two facets of the same problem?

1978 • 491 citations

Role of free radicals in catecholamine-induced cardiomyopathy

1982 • 462 citations

Abrupt reoxygenation of the anoxic potassium-arrested perfused rat heart: A study of myocardial enzyme release

1973 • 443 citations

Localization of xanthine oxidase in mammary-gland epithelium and capillary endothelium

1981 • 435 citations

Mitochondrial Production of Superoxide Radical and Hydrogen Peroxide

1977 • 415 citations

Superoxide dismutase plus catalase enhances the efficacy of hypothermic cardioplegia to protect the globally ischemic, reperfused heart

1982 • 355 citations

Myocardial alterations due to free-radical generation

1984 • 308 citations

Production of free radicals and lipid peroxides in early experimental myocardial ischemia

1983 • 288 citations

Ischemia and reperfusion-induced arrhythmias in the rat. Effects of xanthine oxidase inhibition with allopurinol.

1984 • 265 citations

Quantitative and temporal characterization of the extracellular H2O2 pool generated by human neutrophils.

1984 • 264 citations

Inhibition of surgically induced ischemia/reperfusion injury by oxygen free radical scavengers

1983 • 207 citations

Ultrastructural damage associated with reoxygenation of the anoxic myocardium

1975 • 202 citations

Reduction of myocardial ischemic injury with oxygen-derived free radical scavengers.

1983 • 195 citations

Responses of the ischemic myocardium to allopurinol

1971 • 183 citations

Proton and free oxygen radical interaction with the calcium transport system of cardiac sarcoplasmic reticulum

1981 • 179 citations

Involvement of hydrogen peroxide and hydroxyl radical in the ‘oxygen paradox’: Reduction of creatine kinase release by catalase, allopurinol or deferoxamine, but not by superoxide dismutase**

1985 • 168 citations

Protection of the ischemic myocardium

1978 • 165 citations

Irreversible myocardial injury in anoxic perfused rat hearts.

1975 • 160 citations

Possible role for cytotoxic oxygen metabolites in the pathogenesis of cardiac ischemic injury.

1982 • 160 citations

Effect of a specific iron chelating agent on animal models of inflammation.

1983 • 125 citations

Myocardial protection during ischemic cardiac arrest

1978 • 121 citations

Oxygen-induced enzyme release: Early events and a proposed mechanism

1979 • 120 citations

Enzyme release during myocardial anoxia: A study of metabolic protection

1975 • 110 citations

The β-Adrenergic Blockade Withdrawal Phenomenon

1983 • 107 citations

Hypoxia and oxygen toxicity.

1979 • 103 citations

Oxygen-induced enzyme release after irreversible myocardial injury. Effects of cyanide in perfused rat hearts.

1976 • 88 citations

Glucose, Insulin, Potassium Protection During the Course of Hypothermic Global Ischemia and Reperfusion

1983 • 83 citations

The effect of allopurinol on the degree of early myocardial ischemia

1980 • 64 citations

Mitochondrial Formation of OH˙ Radicals by an Ubisemiquinone-Dependent Reaction An Alternative Pathway to the Iron-Catalysed Haber-Weiss Cycle

1982 • 46 citations

A biochemical and ultrastructural study of the species variation in myocardial cell damage

1976 • 44 citations

Effect of allopurinol (Zyloric) on patients undergoing open heart surgery.

1979 • 42 citations

Beneficial actions of a free radical scavenger in traumatic shock and myocardial ischemia.

1981 • 35 citations

Allopurinol amelioration of the pathophysiology of acute myocardial infarction in rats

1981 • 32 citations

Effect of xanthine oxidase inhibitor on myocardial ischemia.

1976 • 6 citations