Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

1995 • 1,761 citations

Reperfusion injury induces apoptosis in rabbit cardiomyocytes.

1994 • 1,431 citations

Direct measurement of free radical generation following reperfusion of ischemic myocardium.

1987 • 1,185 citations

Apoptosis in Ischemic and Reperfused Rat Myocardium

1996 • 801 citations

Tumor necrosis factor alpha-induced apoptosis in cardiac myocytes. Involvement of the sphingolipid signaling cascade in cardiac cell death.

1996 • 742 citations

The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults

2003 • 722 citations

Measurement of superoxide-derived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury.

1988 • 629 citations

Direct detection of free radicals in the reperfused rat heart using electron spin resonance spectroscopy.

1987 • 628 citations

Mice Deficient in Cellular Glutathione Peroxidase Develop Normally and Show No Increased Sensitivity to Hyperoxia

1997 • 558 citations

Deleterious effects of oxygen radicals in ischemia/reperfusion. Resolved and unresolved issues.

1989 • 518 citations

Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia.

1995 • 484 citations

Increased Oxidative Damage Is Correlated to Altered Mitochondrial Function in Heterozygous Manganese Superoxide Dismutase Knockout Mice

1998 • 454 citations

Mice with a Homozygous Null Mutation for the Most Abundant Glutathione Peroxidase, Gpx1, Show Increased Susceptibility to the Oxidative Stress-inducing Agents Paraquat and Hydrogen Peroxide

1998 • 445 citations

Reduced Fertility in Female Mice Lacking Copper-Zinc Superoxide Dismutase

1998 • 328 citations

Liver Necrosis and Lipid Peroxidation in the Rat as the Result of Paraquat and Diquat Administration

1980 • 284 citations

Necrotic and apoptotic myocyte cell death in the aging heart of Fischer 344 rats

1996 • 275 citations

Manganese Superoxide Dismutase Deficiency Exacerbates Cerebral Infarction After Focal Cerebral Ischemia/Reperfusion in Mice

2002 • 246 citations

Knockout mice heterozygous forSod2show alterations in cardiac mitochondrial function and apoptosis

2001 • 219 citations

Cellular Glutathione Peroxidase Is the Mediator of Body Selenium To Protect against Paraquat Lethality in Transgenic Mice

1998 • 209 citations

Glutathione peroxidase-deficient mice are more susceptible to neutrophil-mediated hepatic parenchymal cell injury during endotoxemia: importance of an intracellular oxidant stress

1999 • 204 citations

Superoxide-Mediated Cytotoxicity in Superoxide Dismutase-Deficient Fetal Fibroblasts

1997 • 167 citations

Characterization of the Antioxidant Status of the Heterozygous Manganese Superoxide Dismutase Knockout Mouse

1999 • 154 citations

Postischemic Recovery of Contractile Function is Impaired in SOD2 ^+/− but Not SOD1 ^+/− Mouse Hearts

2002 • 124 citations

Glutathione peroxidase knockout mice are susceptible to myocardial ischemia reperfusion injury.

1997 • 124 citations

Mitochondrial function, oxygen extraction, epicardial S-T segment changes and tritiated digoxin distribution after reperfusion of ischemic myocardium

1975 • 117 citations

Evidence of direct toxic effects of free radicals on the myocardium

1988 • 105 citations

Opposite Roles of Selenium-dependent Glutathione Peroxidase-1 in Superoxide Generator Diquat- and Peroxynitrite-induced Apoptosis and Signaling

2001 • 97 citations

The effects of ruthenium red on mitochondrial function during post-ischaemic reperfusion

1982 • 95 citations

Oxidant stress and hepatic necrosis in rats treated with diquat.

1985 • 94 citations

Glutathione peroxidase-1 deficiency leads to increased nuclear light scattering, membrane damage, and cataract formation in gene-knockout mice.

2001 • 93 citations

Decreased Pulmonary Radiation Resistance of Manganese Superoxide Dismutase (MnSOD)-Deficient Mice is Corrected by Human Manganese Superoxide Dismutase-Plasmid/Liposome (SOD2-PL) Intratracheal Gene Therapy

2000 • 93 citations

A Simultaneous Visualization of the Antioxidant Enzymes Glutathione Peroxidase and Catalase on Polyacrylamide Gels

1988 • 85 citations

Differential paraquat uptake and redox kinetics of rat granular pneumocytes and alveolar macrophages.

1982 • 79 citations

Regulation of cardiomyocyte apoptosis in ischemic reperfused mouse heart by glutathione peroxidase

1999 • 75 citations

Low glutathione peroxidase activity inGpx1knockout mice protects jejunum crypts from γ-irradiation damage

2000 • 67 citations

Effects of age and food restriction on oxidative DNA damage and antioxidant enzyme activities in the mouse aorta

2001 • 67 citations

Variation in Cellular Glutathione Peroxidase Activity in Lens Epithelial Cells, Transgenics and Knockouts Does Not Significantly Change the Response to H2O2Stress

1996 • 66 citations

Untitled

1999 • 60 citations

Peroxide-Induced Damage in Lenses of Transgenic Mice with Deficient and Elevated Levels of Glutathione Peroxidase

1997 • 54 citations

Edema Formation Exacerbates Neurological and Histological Outcomes After Focal Cerebral Ischemia in CuZn-Superoxide Dismutase Gene Knockout Mutant Mice

1997 • 51 citations

Cellular Glutathione Peroxidase Protects Mice Against Lethal Oxidative Stress Induced by Various Doses of Diquat

1999 • 47 citations

Genetic modification of the dilated cardiomyopathy and neonatal lethality phenotype of mice lacking manganese superoxide dismutase

1998 • 14 citations