Opposite Roles of Selenium-dependent Glutathione Peroxidase-1 in Superoxide Generator Diquat- and Peroxynitrite-induced Apoptosis and Signaling

Mitochondria and Apoptosis

1998 • 8,909 citations

Selenium: Biochemical Role as a Component of Glutathione Peroxidase

1973 • 7,616 citations

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1996 • 5,498 citations

GLUTATHIONE

1983 • 5,487 citations

Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group

1996 • 2,404 citations

Effects of Selenium Supplementation for Cancer Prevention in Patients With Carcinoma of the Skin

1996 • 1,807 citations

Glutathione peroxidase: A selenoenzyme

1973 • 1,358 citations

Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide

1992 • 1,319 citations

Biochemistry of Oxidative Stress

1986 • 1,307 citations

Reactive oxygen species, cell signaling, and cell injury

2000 • 1,005 citations

Protein Oxidation

2000 • 935 citations

Oxidative chemistry of nitric oxide: the roles of superoxide, peroxynitrite, and carbon dioxide

1998 • 800 citations

The stress-activated protein kinase pathways

1999 • 648 citations

DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitrite.

1996 • 630 citations

Quantitation of nitrotyrosine levels in lung sections of patients and animals with acute lung injury.

1994 • 599 citations

Mice Deficient in Cellular Glutathione Peroxidase Develop Normally and Show No Increased Sensitivity to Hyperoxia

1997 • 558 citations

Bipyridylium quaternary salts and related compounds. V. Pulse radiolysis studies of the reaction of paraquat radical with oxygen. Implications for the mode of action of bipyridyl herbicides

1973 • 518 citations

Glutathione Peroxidase Protects against Peroxynitrite-mediated Oxidations

1997 • 470 citations

Mice with a Homozygous Null Mutation for the Most Abundant Glutathione Peroxidase, Gpx1, Show Increased Susceptibility to the Oxidative Stress-inducing Agents Paraquat and Hydrogen Peroxide

1998 • 445 citations

Cleavage of p21Cip1/Waf1 and p27Kip1 Mediates Apoptosis in Endothelial Cells through Activation of Cdk2: Role of a Caspase Cascade

1998 • 441 citations

Vitamin C-Induced Decomposition of Lipid Hydroperoxides to Endogenous Genotoxins

2001 • 413 citations

Rapid genomic evolution of a non-virulent Coxsackievirus B3 in selenium-deficient mice results in selection of identical virulent isolates

1995 • 384 citations

The basic chemistry of nitrogen monoxide and peroxynitrite

1998 • 345 citations

Apoptotic vs. Nonapoptotic Cytotoxicity Induced by Hydrogen Peroxide

1997 • 344 citations

Myeloperoxidase and Horseradish Peroxidase Catalyze Tyrosine Nitration in Proteins from Nitrite and Hydrogen Peroxide

1998 • 311 citations

Peroxynitrite Inhibits T Lymphocyte Activation and Proliferation by Promoting Impairment of Tyrosine Phosphorylation and Peroxynitrite-Driven Apoptotic Death

1999 • 307 citations

Protection against peroxynitrite

1999 • 304 citations

Caspases Induce Cytochrome c Release from Mitochondria by Activating Cytosolic Factors

1999 • 302 citations

Peroxynitrite-induced Apoptosis in HL-60 Cells

1995 • 300 citations

Peroxynitrite‐Induced Cytotoxicity in PC12 Cells: Evidence for an Apoptotic Mechanism Differentially Modulated by Neurotrophic Factors

1995 • 292 citations

Oxidation in the NADP system and release of GSSG from hemoglobin‐free perfused rat liver during peroxidatic oxidation of glutathione by hydroperoxides

1972 • 257 citations

Cellular Glutathione Peroxidase Is the Mediator of Body Selenium To Protect against Paraquat Lethality in Transgenic Mice

1998 • 209 citations

A mechanism of paraquat toxicity involving nitric oxide synthase

1999 • 200 citations

An Apoptotic Model for Nitrosative Stress

2000 • 185 citations

Selenocysteine-containing proteins in mammals

1999 • 178 citations

Glutathione peroxidase activity in rat lens and other tissues in relation to dietary selenium intake

1974 • 174 citations

Protective Role of p21^Waf1/Cip1 against Prostaglandin A₂-Mediated Apoptosis of Human Colorectal Carcinoma Cells

1996 • 160 citations

Cellular Glutathione Peroxidase Knockout Mice Express Normal Levels of Selenium-Dependent Plasma and Phospholipid Hydroperoxide Glutathione Peroxidases in Various Tissues , ,

1997 • 159 citations

GSH extrusion and the mitochondrial pathway of apoptotic signalling

2000 • 156 citations

Caspase 3-mediated Cleavage of p21 Associated with the Cyclin A-Cyclin-dependent Kinase 2 Complex Is a Prerequisite for Apoptosis in SK-HEP-1 Cells

2000 • 148 citations

Selenium, the Element of the Moon, in Life on Earth

2000 • 143 citations

Inactivation of Glutathione Peroxidase by Peroxynitrite

1998 • 133 citations

Selenium‐dependent cellular glutathione peroxidase protects mice against a pro‐oxidant‐induced oxidation of NADPH, NADH, lipids, and protein

1999 • 131 citations

Knockout of cellular glutathione peroxidase gene renders mice susceptible to diquat-induced oxidative stress

1999 • 126 citations

Activation pattern of mitogen‐activated protein kinases elicited by peroxynitrite: attenuation by selenite supplementation

1999 • 126 citations

Acetaminophen Toxicity

1999 • 123 citations

Superoxide Formation and Macrophage Resistance to Nitric Oxide-mediated Apoptosis

1997 • 121 citations

Selenite Inhibits the c-Jun N-terminal Kinase/Stress-activated Protein Kinase (JNK/SAPK) through a Thiol Redox Mechanism

2000 • 119 citations

Enhanced skin carcinogenesis in transgenic mice with high expression of glutathione peroxidase or both glutathione peroxidase and superoxide dismutase.

1997 • 108 citations

Selenium Biochemistry: Mammalian Selenoenzymes

2000 • 94 citations

Prooxidant role of vitamin E in copper induced lipid peroxidation

1993 • 93 citations

Nitrite and nitrosamine synthesis by hepatocytes isolated from normal woodchucks (Marmota monax) and woodchucks chronically infected with woodchuck hepatitis virus.

1992 • 74 citations

Superoxide dismutases enhance H₂O₂‐induced DNA damage and alter its site specificity

2001 • 48 citations

Chronic Brain Oxidation in a Glutathione Peroxidase Knockout Mouse Model Results in Increased Resistance to Induced Epileptic Seizures

2000 • 41 citations

Reactive Oxygen Species and their Cytotoxic Mechanisms

1997 • 35 citations