production and release of endothelin-1 from the gut and spleen in portal hypertension due to cirrhosis

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Cloning and expression of a cDNA encoding an endothelin receptor

1990 • 2,590 citations

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

1989 • 2,551 citations

Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor

1990 • 2,432 citations

ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1

1994 • 932 citations

Endothelins

1995 • 682 citations

The morphology of cirrhosis. Recommendations on definition, nomenclature, and classification by a working group sponsored by the World Health Organization.

1978 • 452 citations

Hyperdynamic circulation in portal-hypertensive rat model: a primary factor for maintenance of chronic portal hypertension

1983 • 433 citations

Reduced nitric oxide production by endothelial cells in cirrhotic rat liver: Endothelial dysfunction in portal hypertension

1998 • 411 citations

Endothelin 1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells

1996 • 396 citations

The contraction of hepatic stellate (Ito) cells stimulated with vasoactive substances

1993 • 391 citations

Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver: implications for regulation of portal pressure and resistance

1996 • 377 citations

Reduction of the increased portal vascular resistance of the isolated perfused cirrhotic rat liver by vasodilators

1985 • 367 citations

A novel, simple, reliable, and sensitive method for multiple immunoenzyme staining: use of microwave oven heating to block antibody crossreactivity and retrieve antigens.

1995 • 358 citations

17 beta-Estradiol attenuates voltage-dependent Ca2+ currents in A7r5 vascular smooth muscle cell line

1994 • 342 citations

Fat-storing cells as liver-specific pericytes. Spatial dynamics of agonist-stimulated intracellular calcium transients.

1992 • 338 citations

The cellular pathogenesis of portal hypertension: Stellate cell contractility, endothelin, and nitric oxide

1997 • 334 citations

Increased Blood Flow Through the Portal System in Cirrhotic Rats

1984 • 327 citations

Endothelin-1 induces direct constriction of hepatic sinusoids

1994 • 300 citations

[Plasma endothelin immunoreactivity in liver disease and the hepatorenal syndrome].

1993 • 295 citations

Activation-dependent contractility of rat hepatic lipocytes in culture and in vivo.

1993 • 264 citations

Cellular localization of endothelin-1 and increased production in liver injury in the rat: Potential for autocrine and paracrine effects on stellate cells

1998 • 230 citations

Circulating levels of endothelin in cirrhosis

1993 • 202 citations

Endothelin, a potent peptide agonist in the liver.

1990 • 161 citations

Clinical significance of elevated plasma endothelin concentration in patients with cirrhosis

1992 • 159 citations

ET-1 induced alterations of hepatic microcirculation: sinusoidal and extrasinusoidal sites of action

1994 • 142 citations

Ito cell contraction in response to endothelin-1 and substance P

1993 • 122 citations

Endothelin-1 and endothelin-3 in cirrhosis: Relations to systemic and splanchnic haemodynamics

1995 • 114 citations

Roles of endothelin-1 and nitric oxide in the mechanism for ethanol-induced vasoconstriction in rat liver.

1993 • 112 citations

Endothelin-1 and -3 plasma concentrations in patients with cirrhosis: Role of splanchnic and renal passage and liver function†

1995 • 110 citations

Vasoactive effect of endothelin-1 on rat liver in vivo

1994 • 108 citations

Endothelin-1-induced vasoconstriction causes a significant increase in portal pressure of rat liver: Localized constrictive effect on the distal segment of preterminal portal venules as revealed by light and electron microscopy and serial reconstruction

1998 • 102 citations

Elevated circulating plasma endothelin-1 concentrations in cirrhosis

1993 • 80 citations

Portal Hypertension

1989 • 79 citations

Regulation of endothelin‐1 action on the perfused rat liver

1993 • 77 citations

Plasma endothelin-1 and -3 in cirrhosis: relationship with systemic hemodynamics, renal function and neurohumoral systems

1996 • 64 citations

Plasma endothelin levels in patients with cirrhosis and their relationships to the severity of cirrhosis and renal function

1995 • 55 citations

Increased plasma endothelin in cirrhosis. Relationship with systemic endotoxemia and response to changes in effective blood volume

1995 • 48 citations

Clinical significance of plasma endothelin-1 in patients with chronic liver disease

1994 • 43 citations

High plasma concentrations of endothelin-like immunoreactivities in patients with hepatocellular carcinoma.

1993 • 43 citations

Changes in plasma endothelin-1 and Big endothelin-1 induced by transjugular intrahepatic portosystemic shunts in patients with cirrhosis and refractory ascites

1996 • 43 citations

Endothelin-1 induces liver vasoconstriction through both ETA and ETB receptors

1997 • 41 citations

Endothelin-1 production by hepatic endothelial cells: characterization and augmentation by endotoxin exposure

1997 • 40 citations

Multiple hepatic functions of endothelin-1: physiopathological relevance

1996 • 34 citations

Hepatic lipocytes: a major target for endothelin-1.

1995 • 29 citations

Endothelin-1 Induces Cholestasis Which Is Mediated by an Increase in Portal Pressure

1993 • 25 citations

Immunohistochemical localization of endothelin-1/big endothelin-1 in normal liver, liver cirrhosis and hepatocellular carcinoma.

1998 • 10 citations

Role of splenectomy in hepatic resection for hepatocellular carcinoma associated with severe cirrhosis and hypersplenism

1999 • 8 citations

Deleted Work

1955 • 0 citations