Increased plasma endothelin in cirrhosis. Relationship with systemic endotoxemia and response to changes in effective blood volume

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.

1989 • 2,551 citations

Peripheral arterial vasodilation hypothesis: A proposal for the initiation of renal sodium and water retention in cirrhosis

1988 • 1,606 citations

Metabolic equivalents (METS) in exercise testing, exercise prescription, and evaluation of functional capacity

1990 • 1,263 citations

Reflex control of the circulation during exercise: chemoreflexes and mechanoreflexes

1990 • 736 citations

Human Circulation: Regulation During Physical Stress

1986 • 683 citations

Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist

1993 • 529 citations

Endothelins, peptides with potent vasoactive properties, are produced by human macrophages.

1990 • 462 citations

Molecular and cellular mechanism of endothelin regulation. Implications for vascular function.

1991 • 391 citations

Endothelin action on vascular smooth muscle involves inositol trisphosphate and calcium mobilization

1989 • 346 citations

Immunoreactive endothelin in human plasma: Marked elevations in patients in cardiogenic shock

1989 • 330 citations

Endothelin: A Novel Peptide in the Posterior Pituitary System

1990 • 313 citations

Endothelins: multifunctional renal peptides.

1993 • 306 citations

[Plasma endothelin immunoreactivity in liver disease and the hepatorenal syndrome].

1993 • 295 citations

Increased endothelin in experimental heart failure.

1990 • 288 citations

Endotoxin stimulates endothelin-release in vivo and in vitro as determined by radioimmunoassay

1989 • 265 citations

Interleukin 1 increases the production of endothelin-1 by cultured endothelial cells

1990 • 259 citations

Elevated endothelin-1 in heart failure and loss of normal response to postural change.

1992 • 251 citations

Elevated Plasma Endothelin-1 Concentrations Are Associated with the Severity of Illness in Patients with Sepsis

1991 • 227 citations

Endothelins: circulating plasma levels and presence in other biologic fluids.

1993 • 207 citations

Regulation during Physical Stress

1986 • 204 citations

Circulating levels of endothelin in cirrhosis

1993 • 202 citations

Clinical significance of elevated plasma endothelin concentration in patients with cirrhosis

1992 • 159 citations

Atrial natriuretic factor in cirrhosis with ascites: Plasma levels, cardiac release and splanchnic extraction

1988 • 158 citations

Adrian Edmund Gill (1937–1986)

1986 • 152 citations

Cardiovascular control during exercise: Central and reflex neural mechanisms

1985 • 148 citations

Plasma endothelin during upright tilt: relevance for orthostatic hypotension?

1991 • 144 citations

Elevated plasma levels of endothelin in patients with sepsis syndrome.

1991 • 137 citations

Endothelins in the control of cardiovascular and renal function

1993 • 113 citations

Plasma Norepinephrine, Weak Neurotransmitters, and Renin Activity During Active Tilting in Liver Cirrhosis: Relationship with Cardiovascular Homeostasis and Renal Function

1983 • 103 citations

Increased plasma and pulmonary lymph levels of endothelin during endotoxin shock

1989 • 102 citations

Production of Endothelin-1 in Vascular Endothelial Cells Is Regulated by Factors Associated with Vascular Injury

1992 • 98 citations

Modulation of Circulating Endothelin Levels in Hypertension and Endotoxemia in Rats

1991 • 63 citations

Increased plasma levels of endothelin‐like immunoreactivity during endotoxin administration in the pig

1989 • 54 citations

Cloning and chromosomal localization of a human endothelin ETA receptor

1991 • 49 citations

Endothelin-3 like immunoreactivity in plasma of patients with cirrhosis of the liver

1992 • 33 citations

Endothelin regulation of neuropeptide release from nerve endings of the posterior pituitary.

1992 • 33 citations

Impairment of Blood Pressure Control in Patients with Liver Cirrhosis during Tilting: Study on Adrenergic and Renin-Angiotensin Systems

1982 • 32 citations

Plasma-Endothelin bei Normalpersonen und Patienten mit nephrologisch-rheumatologischen und kardiovaskulären Erkrankungen

1990 • 31 citations

Circulatory responses to endothelin-1 and nitric oxide with special reference to endotoxin shock and nitric oxide inhalation.

1993 • 29 citations

Endothelin in thoracic inferior vena caval constriction model of heart failure

1992 • 24 citations

Chronic Synergistic Effect of Endothelin-1 and Angiotensin II on Blood Pressure in Conscious Rats

1991 • 14 citations

Endothelin an endocrine role

1992 • 14 citations

Plasma endothelin‐1 during central hypovolaemia in man

1992 • 11 citations