Thrombomodulin structure and function.

Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C.

1981 • 831 citations

Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C.

1982 • 709 citations

TAFI, or Plasma Procarboxypeptidase B, Couples the Coagulation and Fibrinolytic Cascades through the Thrombin-Thrombomodulin Complex

1996 • 641 citations

Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface

1995 • 380 citations

Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation.

1987 • 358 citations

Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system.

1995 • 235 citations

Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene

1987 • 209 citations

Functional Mapping of the Surface Residues of Human Thrombin

1995 • 166 citations

The Last Three Consecutive Epidermal Growth Factor-like Structures of Human Thrombomodulin Comprise the Minimum Functional Domain for Protein C-activating Cofactor Activity and Anticoagulant Activity

1989 • 149 citations

A 10-kDa cyanogen bromide fragment from the epidermal growth factor homology domain of rabbit thrombomodulin contains the primary thrombin binding site.

1988 • 130 citations

Single amino acid substitutions dissociate fibrinogen-clotting and thrombomodulin-binding activities of human thrombin.

1991 • 129 citations

Characterization of a thrombomodulin cDNA reveals structural similarity to the low density lipoprotein receptor.

1986 • 125 citations

Stable expression of a secretable deletion mutant of recombinant human thrombomodulin in mammalian cells.

1990 • 117 citations

Multiple active forms of thrombin. IV. Relative activities of meizothrombins.

1990 • 117 citations

Multiple Active Forms of Thrombin

1971 • 108 citations

Functional domains of membrane-bound human thrombomodulin. EGF-like domains four to six and the serine/threonine-rich domain are required for cofactor activity.

1992 • 105 citations

Proteolytic formation and properties of functional domains of thrombomodulin.

1987 • 98 citations

Equilibrium binding of thrombin to recombinant human thrombomodulin: effect of hirudin, fibrinogen, factor Va, and peptide analogs

1990 • 88 citations

Further localization of binding sites for thrombin and protein C in human thrombomodulin

1990 • 80 citations

Modulation of glycosaminoglycan addition in naturally expressed and recombinant human thrombomodulin.

1994 • 80 citations

Alanine-scanning mutagenesis of the epidermal growth factor-like domains of human thrombomodulin identifies critical residues for its cofactor activity.

1993 • 80 citations

Large-scale expression, purification and characterization of small fragments of thrombomodulin: the roles of the sixth domain and of methionine 388

1995 • 75 citations

Structure of a nonadecapeptide of the fifth EGF domain of thrombomodulin complexed with thrombin

1994 • 62 citations

The amino‐terminal domain of thrombomodulin and pancreatic stone protein are homologous with lectins

1988 • 61 citations

The chondroitin sulfate moiety of thrombomodulin binds a second molecule of thrombin.

1993 • 58 citations

The short loop between epidermal growth factor-like domains 4 and 5 is critical for human thrombomodulin function.

1993 • 57 citations

The Shape of Thrombomodulin and Interactions with Thrombin as Determined by Electron Microscopy

1996 • 54 citations

Identification of the predominant glycosaminoglycan-attachment site in soluble recombinant human thrombomodulin: potential regulation of functionality by glycosyltransferase competition for serine474

1993 • 51 citations

Aspartic acid 349 in the fourth epidermal growth factor-like structure of human thrombomodulin plays a role in its Ca(2+)-mediated binding to protein C.

1991 • 44 citations

Occupancy of anion binding exosite 2 on thrombin determines Ca2+ dependence of protein C activation.

1994 • 43 citations

Recombinant human thrombomodulin. Regulation of cofactor activity and anticoagulant function by a glycosaminoglycan side chain

1992 • 36 citations

Sequences required for thrombomodulin cofactor activity within the fourth epidermal growth factor-like domain of human thrombomodulin

1993 • 28 citations

Thrombin-bound structure of an EGF subdomain from human thrombomodulin determined by transferred nuclear Overhauser effects

1994 • 25 citations

The fifth epidermal growth factor-like domain of thrombomodulin does not have an epidermal growth factor-like disulfide bonding pattern.

1996 • 24 citations

Synthesis, activity, and preliminary structure of the fourth EGF-like domain of thrombomodulin

1995 • 22 citations

Structural resiliency of an EGF‐like subdomain bound to its target protein, thrombin

1996 • 18 citations

Thrombin‐binding affinities of different disulfide‐bonded isomers of the fifth EGF‐like domain of thrombomodulin

1995 • 18 citations