Increased circulating thrombomodulin in children with septic shock

Pediatric risk of mortality (PRISM) score

1988 • 1,395 citations

Modulation of endothelial cell hemostatic properties by tumor necrosis factor.

1986 • 1,335 citations

The Roles of Protein C and Thrombomodulin in the Regulation of Blood Coagulation

1989 • 1,059 citations

Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon.

1987 • 836 citations

Septic Shock, Multiple Organ Failure, and Disseminated Intravascular Coagulation

1992 • 708 citations

Soluble forms of E-selectin, ICAM-1 and VCAM-1 are present in the supernatants of cytokine activated cultured endothelial cells

1992 • 653 citations

Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro.

1987 • 467 citations

Soluble cytokine receptors are present in normal human urine.

1989 • 441 citations

Soluble Thrombomodulin Antigen in Conditioned Medium Is Increased by Damage of Endothelial Cells

1991 • 345 citations

Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture

1989 • 337 citations

Time Course of Hemostatic Abnormalities in Sepsis and its Relation to Outcome

1993 • 310 citations

Tumor necrosis factor increases the production of plasminogen activator inhibitor in human endothelial cells in vitro and in rats in vivo

1988 • 300 citations

Plasma thrombomodulin in health and diseases

1990 • 296 citations

The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent

1996 • 294 citations

Outcome of pediatric patients with multiple organ system failure

1986 • 271 citations

Tumor necrosis factor increases the production of plasminogen activator inhibitor in human endothelial cells in vitro and in rats in vivo

1988 • 232 citations

Mortality associated with multiple organ system failure and sepsis in pediatric intensive care unit

1987 • 221 citations

Thrombomodulin blocks the ability of thrombin to activate platelets.

1983 • 220 citations

Release of thrombomodulin from endothelial cells by concerted action of TNF-alpha and neutrophils: in vivo and in vitro studies.

1996 • 193 citations

Pathophysiology and Treatment of Septic Shock

1991 • 172 citations

Demonstration of Rickettsia conorii-induced endothelial injury in vivo by measuring circulating endothelial cells, thrombomodulin, and von Willebrand factor in patients with Mediterranean spotted fever [see comments]

1993 • 165 citations

RETRACTED: Normothermic versus hypothermic cardiopulmonary bypass: Do changes in coagulation differ?

1996 • 102 citations

Granulocyte proteases and hydrogen peroxide synergistically inactivate thrombomodulin of endothelial cells in vitro.

1994 • 88 citations

Activation and inhibition of fibrinolysis in septic patients in an internal intensive care unit

1990 • 79 citations

Plasma levels of soluble thrombomodulin increase in cases of disseminated intravascular coagulation with organ failure

1991 • 75 citations

Increased plasma levels of soluble thrombomodulin in patients with sepsis and organ failure

1995 • 62 citations

Regulatory mechanisms for thrombomodulin expression in human umbilical vein endothelial cells in vitro

1991 • 58 citations

Developmentally regulated gene expression of thrombomodulin in postimplantation mouse embryos

1996 • 57 citations

Thrombomodulin is preferentially expressed in Balb/c lung microvessels.

1992 • 56 citations

Serum thrombomodulin and anticardiolipin antibodies in patients with systemic lupus erythematosus.

1991 • 47 citations

Effects of Recombinant Human Soluble Thrombomodulin (rhs-TM) on a Rat Model of Disseminated Intravascular Coagulation with Decreased Levels of Plasma Antithrombin III

1994 • 46 citations

Antithrombotic effect of recombinant human soluble thrombomodulin on endotoxin-induced disseminated intravascular coagulation in rats

1993 • 44 citations

Serum levels of adhesion molecules and thrombomodulin as indicators of vascular injury in severe Plasmodium falciparum malaria

1994 • 41 citations

The effects of recombinant human thrombomodulin on endotoxin-induced multiple-system organ failure in rats.

1996 • 36 citations

Thrombomodulin Release in Baboon Sepsis: Its Dependence on the Dose of Escherichia coli and the Presence of Tumor Necrosis Factor

1995 • 35 citations

Intravenous recombinant soluble human thrombomodulin prevents venous thrombosis in a rat model

1991 • 26 citations

Influence of long-term continuous intravenous administration of pentoxifylline on endothelial-related coagulation in critically ill patients

1996 • 22 citations

Thrombomodulin and angiotensin-converting enzyme activity during pediatric open heart operations.

1996 • 20 citations

Thrombomodulin and angiotensin-converting enzyme activity during pediatric open heart operations

1996 • 17 citations

Changes in thrombomodulin level in plasma of endotoxin-infused rabbits

1992 • 16 citations

Antithrombotic Effects of Recombinant Human Soluble Thrombomodulin in a Rat Model of Vascular Shunt Thrombosis

1994 • 15 citations

Measurement of soluble thrombomodulin in sera from various clinical stages of diabetic nephropathy

1996 • 13 citations

Plasma Thrombomoduhn: Usefulness as a Blood Access Failure Marker in Hemodialysis Patients

1996 • 8 citations