Nascent secretory chain binding and translocation are distinct processes: differentiation by chemical alkylation.

Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma.

1975 • 3,026 citations

Signal sequences

1985 • 2,179 citations

Intracellular protein topogenesis

1980 • 1,378 citations

The spontaneous insertion of proteins into and across membranes: The helical hairpin hypothesis

1981 • 868 citations

Protein translocation across the endoplasmic reticulum

1984 • 825 citations

Translocation of proteins across the endoplasmic reticulum III. Signal recognition protein (SRP) causes signal sequence-dependent and site-specific arrest of chain elongation that is released by microsomal membranes.

1981 • 807 citations

How signal sequences maintain cleavage specificity

1984 • 725 citations

[6] Preparation of microsomal membranes for cotranslational protein translocation

1983 • 679 citations

Secretory protein translocation across membranes—the role of the ‘docking protein’

1982 • 648 citations

Translocation of proteins across the endoplasmic reticulum. I. Signal recognition protein (SRP) binds to in-vitro-assembled polysomes synthesizing secretory protein.

1981 • 644 citations

Protein translocation across the endoplasmic reticulum. II. Isolation and characterization of the signal recognition particle receptor.

1982 • 478 citations

Translocation of proteins across the endoplasmic reticulum. II. Signal recognition protein (SRP) mediates the selective binding to microsomal membranes of in-vitro-assembled polysomes synthesizing secretory protein.

1981 • 414 citations

The Assembly of Proteins into Biological Membranes: The Membrane Trigger Hypothesis

1979 • 408 citations

Protein translocation across the endoplasmic reticulum. I. Detection in the microsomal membrane of a receptor for the signal recognition particle.

1982 • 388 citations

Membrane assembly in vitro : Synthesis, glycosylatio, and asymmetric insertion of a transmembrane protein

1977 • 366 citations

Trans‐membrane Translocation of Proteins

1979 • 364 citations

The Stability of N-Ethylmaleimide and its Reaction with Sulfhydryl Groups

1955 • 340 citations

CONTROLLED PROTEOLYSIS OF NASCENT POLYPEPTIDES IN RAT LIVER CELL FRACTIONS

1970 • 320 citations

CONTROLLED PROTEOLYSIS OF NASCENT POLYPEPTIDES IN RAT LIVER CELL FRACTIONS

1970 • 301 citations

A signal sequence receptor in the endoplasmic reticulum membrane

1987 • 291 citations

Partial resistance of nascent polypeptide chains to proteolytic digestion due to ribosomal shielding

1967 • 290 citations

Translocation of secretory proteins across the microsomal membrane occurs through an environment accessible to aqueous perturbants

1985 • 277 citations

Formation of a functional ribosome-membrane junction during translocation requires the participation of a GTP-binding protein.

1986 • 199 citations

Formation of an intrachain disulfide bond on nascent immunoglobulin light chains.

1979 • 199 citations

The signal recognition particle receptor is a complex that contains two distinct polypeptide chains.

1986 • 189 citations

Nascent polypeptide chains emerge from the exit domain of the large ribosomal subunit: immune mapping of the nascent chain.

1982 • 142 citations

Nucleotide sequence of bovine prolactin messenger RNA. Evidence for sequence polymorphism.

1982 • 123 citations

Characterization of secretory protein translocation: ribosome-membrane interaction in endoplasmic reticulum.

1986 • 121 citations

A former amino terminal signal sequence engineered to an internal location directs translocation of both flanking protein domains.

1985 • 98 citations

On the translocation of proteins across membranes.

1987 • 95 citations

Integration of membrane proteins into the endoplasmic reticulum requires GTP.

1988 • 48 citations

Guanosine triphosphate promotes the post-translational integration of opsin into the endoplasmic reticulum membrane.

1988 • 42 citations

Extensions of the signal hypothesis ‐ sequential insertion model versus amphipathic tunnel hypothesis

1985 • 34 citations

Secretion requires a cytoplasmically disposed sulphydryl of the RER membrane

1980 • 30 citations