Animal models of steatohepatitis

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

2002 • 18,132 citations

Nonalcoholic Steatohepatitis Mayo Clinic Experiences With a Hitherto Unnamed Disease

1980 • 2,667 citations

Protection from obesity-induced insulin resistance in mice lacking TNF-α function

1997 • 2,190 citations

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

1998 • 2,143 citations

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

2001 • 1,849 citations

Association of nonalcoholic fatty liver disease with insulin resistance

1999 • 1,560 citations

Fatty liver hepatitis (steatohepatitis) and obesity: An autopsy study with analysis of risk factors

1990 • 1,210 citations

Leptin regulates proinflammatory immune responses

1998 • 1,161 citations

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

1999 • 1,040 citations

Cytokines in Alcoholic and Nonalcoholic Steatohepatitis

2000 • 936 citations

Obesity increases sensitivity to endotoxin liver injury: Implications for the pathogenesis of steatohepatitis

1997 • 815 citations

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.

1996 • 802 citations

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

1998 • 797 citations

Tumor Necrosis Factor, Other Cytokines and Disease

1993 • 788 citations

Life without white fat: a transgenic mouse

1998 • 782 citations

Prevention of fat-induced insulin resistance by salicylate

2001 • 713 citations

Essential role of tumor necrosis factor α in alcohol-induced liver injury in mice

1999 • 704 citations

Antibiotics prevent liver injury in rats following long-term exposure to ethanol

1995 • 698 citations

Metformin reverses fatty liver disease in obese, leptin-deficient mice

2000 • 680 citations

Excess weight risk factor for alcoholic liver disease

1997 • 633 citations

Obesity

1997 • 575 citations

Vitamin E treatment of nonalcoholic steatohepatitis in children: A pilot study

2000 • 532 citations

The OB Protein (Leptin) Pathway - A Link Between Adipose Tissue Mass and Central Neural Networks

1996 • 517 citations

Leptin regulates proinflammatory immune responses

1998 • 487 citations

Animal Models of Steatosis

2001 • 446 citations

Obesity Induces Expression of Uncoupling Protein-2 in Hepatocytes and Promotes Liver ATP Depletion

1999 • 442 citations

Lactobacillus Feeding Reduces Endotoxemia and Severity of Experimental Alcoholic Liver (Disease)

1994 • 441 citations

Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study

2001 • 428 citations

A Pilot Study of A Thiazolidinedione, Troglitazone, in Nonalcoholic Steatohepatitis

2001 • 392 citations

Effect of weight reduction on hepatic abnormalities in overweight patients

1990 • 381 citations

Mitochondrial Adaptations to Obesity-Related Oxidant Stress

2000 • 362 citations

Increased gastrointestinal ethanol production in obese mice: Implications for fatty liver disease pathogenesis

2000 • 341 citations

Leptin enhances wound re-epithelialization and constitutes a direct function of leptin in skin repair

2000 • 302 citations

Activation of caspase 3 (CPP32)-like proteases is essential for TNF-alpha-induced hepatic parenchymal cell apoptosis and neutrophil-mediated necrosis in a murine endotoxin shock model.

1998 • 302 citations

Cytokine regulation of liver injury and repair

2000 • 296 citations

Leptin deficiency enhances sensitivity to endotoxin-induced lethality

1999 • 287 citations

Impaired mitochondrial function in microvesicular steatosis effects of drugs, ethanol, hormones and cytokines

1997 • 261 citations

Activation of Caspase 3 (CPP32)-Like Proteases Is Essential for TNF-α-Induced Hepatic Parenchymal Cell Apoptosis and Neutrophil-Mediated Necrosis in a Murine Endotoxin Shock Model

1998 • 253 citations

Disrupted signaling and inhibited regeneration in obese mice with fatty livers: Implications for nonalcoholic fatty liver disease pathophysiology

2001 • 234 citations

Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver

1999 • 198 citations

Altered hepatic lymphocyte subpopulations in obesity-related murine fatty livers: Potential mechanism for sensitization to liver damage

2000 • 191 citations

Transdifferentiation of Rat Hepatic Stellate Cells Results in Leptin Expression

1998 • 181 citations

Molecular mapping of the mouse ob mutation

1991 • 179 citations

Dietary choline restriction causes complex I dysfunction and increased H2O2 generation in liver mitochondria

2000 • 177 citations

NASH: From liver diseases to metabolic disorders and back to clinical hepatology

2002 • 160 citations

Vitamin E treatment of nonalcoholic steatohepatitis in children: A pilot study

2000 • 142 citations

Long-term Morbidity Following Jejunoileal Bypass

1995 • 141 citations

Jejunoileal bypass for morbid obesity

1978 • 138 citations

Molecular mapping of the mouse db mutation.

1990 • 102 citations

Mitochondrial uncoupling: role of uncoupling protein anion carriers and relationship to thermogenesis and weight control "the benefits of losing control".

1999 • 94 citations

The rapid induction of liver cell death in rats fed a choline-deficient methionine-low diet.

1983 • 90 citations

Transgenic Mice Lacking White Fat: Models for Understanding Human Lipoatrophic Diabetes

1999 • 80 citations

Fasting in obesity

1982 • 79 citations

Prognostic indicators of hepatic injury following jejunoileal bypass performed for refractory obesity: A prospective study

1981 • 54 citations

Reversal of severe fatty hepatic infiltration after intestinal bypass for morbid obesity by calorie-free amino acid infusion

1975 • 54 citations

Pioglitazone and Metformin Reverse Insulin Resistance Induced by Tumor Necrosis Factor-Alpha in Liver Cells

1997 • 54 citations

Morphological changes of organs after sucrose or fructose feeding.

1986 • 44 citations

Effects of Two Synthetic Antioxidants, Vitamin E, and Ascorbic Acid on the Choline-deficient Rat

1969 • 36 citations

Resolution of venous stasis retinopathy after carotid artery bypass surgery.

1980 • 32 citations

Fatty liver induced in Zucker "fatty" (ff) rats by a semisynthetic diet rich in sucrose.

1977 • 24 citations

Obesity and hepatotoxins as risk factors for fatty liver disease.

1991 • 22 citations

Dietary Arachidonic Acid Protects Mice against the Fatty Liver Induced by a High Fat Diet and by Ethanol

1984 • 19 citations