Activation of caspase 3 (CPP32)-like proteases is essential for TNF-alpha-induced hepatic parenchymal cell apoptosis and neutrophil-mediated necrosis in a murine endotoxin shock model.

Apoptosis by Death Factor

1997 • 5,038 citations

Pathogenetic Mechanisms of Septic Shock

1993 • 1,577 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

A novel domain within the 55 kd TNF receptor signals cell death

1993 • 1,302 citations

Two TNF receptors

1992 • 1,048 citations

Two tumour necrosis factor receptors: structure and function

1995 • 800 citations

A License to Kill

1996 • 649 citations

Cytokine-induced respiratory burst of human neutrophils: dependence on extracellular matrix proteins and CD11/CD18 integrins.

1989 • 577 citations

Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models.

1995 • 493 citations

Activation of the 55 kDa TNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis, and nitrite release.

1995 • 332 citations

The role of cytokine networks in the local liver injury following hepatic ischemia/reperfusion in the rat

1996 • 312 citations

Systemic injection of a tripeptide inhibits the intracellular activation of CPP32-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death.

1996 • 281 citations

Apoptosis and hepatobiliary disease

1995 • 268 citations

Role of cytokines in the pathogenesis of cardiopulmonary-induced multisystem organ failure

1993 • 266 citations

Neutrophil-induced liver cell injury in endotoxin shock is a CD11b/CD18-dependent mechanism

1991 • 237 citations

Listeria monocytogenes induces apoptosis of infected hepatocytes.

1996 • 213 citations

Cytokine-induced gene expression of a neutrophil chemotactic factor/IL-8 in human hepatocytes.

1990 • 211 citations

Characterization of seven murine caspase family members

1997 • 207 citations

Cytokine-induced upregulation of hepatic intercellular adhesion molecule-1 messenger RNA expression and its role in the pathophysiology of murine endotoxin shock and acute liver failure

1995 • 180 citations

Neutrophil margination and extravasation in sinusoids and venules of liver during endotoxin-induced injury

1997 • 162 citations

Mechanism of hepatocellular dysfunction during hyperdynamic sepsis

1996 • 160 citations

A central role for IL-1 beta in the in vitro and in vivo regulation of hepatic inducible nitric oxide synthase. IL-1 beta induces hepatic nitric oxide synthesis.

1995 • 155 citations

Endotoxin-induced activation of the nuclear transcription factor kappa B and expression of E-selectin messenger RNA in hepatocytes, Kupffer cells, and endothelial cells in vivo.

1996 • 153 citations

Complement and tumor necrosis factor-α contribute to Mac-1 (CD11b/CD18) up-regulation and systemic neutrophil activation during endotoxemia in vivo

1994 • 143 citations

Involvement of tumor necrosis factor in endotoxin-triggered neutrophil adherence to sinusoidal endothelial cells of mouse liver and its modulation in acute phase

1988 • 132 citations

SEQUESTRATION OF NEUTROPHILS IN THE HEPATIC VASCULATURE DURING ENDOTOXEMIA IS INDEPENDENT OF β2 INTEGRINS AND INTERCELLULAR ADHESION MOLECULE-1

1996 • 131 citations

Transcriptional activation of vascular cell adhesion molecule-1 gene in vivo and its role in the pathophysiology of neutrophil-induced liver injury in murine endotoxin shock.

1997 • 126 citations

INHIBITION OF NF-KB ACTIVATION BY DIMETHYL SULFOXIDE CORRELATES WITH SUPPRESSION OF TNF-α FORMATION, REDUCED ICAM-1 GENE TRANSCRIPTION, AND PROTECTION AGAINST ENDOTOXIN-INDUCED LIVER INJURY

1997 • 115 citations

Apoptotic cell death in the response of D-galactosamine-sensitized mice to lipopolysaccharide as an experimental endotoxic shock model

1996 • 111 citations

ICE inhibitor YVADcmk is a potent therapeutic agent against in vivo liver apoptosis

1996 • 97 citations

Mechanism of Hepatocellular Dysfunction During Early Sepsis

1997 • 90 citations

Processing/activation of CPP32-like proteases is involved in transforming growth factor ?1-induced apoptosis in rat hepatocytes

1997 • 88 citations

Tumor necrosis factor receptor p55 is essential for intrahepatic granuloma formation and hepatocellular apoptosis in a murine model of bacterium-induced fulminant hepatitis

1997 • 81 citations

A cleavage-site-directed inhibitor of interleukin-1β-converting enzyme-like proteases inhibits apoptosis in primary cultures of rat hepatocytes

1996 • 76 citations

Characterization of hepatic nitric oxide synthase: identification as the cytokine-inducible form primarily regulated by oxidants.

1996 • 72 citations

Differential Induction of mRNA for ICAM-1 and Selectins in Hepatocytes, Kupffer Cells and Endothelial Cells During Endotoxemia

1995 • 71 citations

ENDOTOXIC SHOCK LEADS TO APOPTOSIS IN VIVO AND REDUCES Bcl-2

1996 • 61 citations

Involvement of ICE family proteases in apoptosis induced by reoxygenation of hypoxic hepatocytes

1996 • 58 citations

Tumor necrosis factor-alpha stimulates superoxide anion generation by perfused rat liver and Kupffer cells

1991 • 52 citations

Quinine inhibits release of tumor necrosis factor, apoptosis, necrosis and mortality in a murine model of septic liver failure

1995 • 49 citations

Multiple Pathways of Fas-Induced Apoptosis in Primary Culture of Hepatocytes

1996 • 45 citations

Release of soluble intercellular adhesion molecule 1 into bile and serum in murine endotoxin shock

1996 • 36 citations

Apoptosis: function and regulation of cell death

1996 • 27 citations

The inflammatory potential of IL-2: local induction of a specific chronic granulomatous lesion in mice

1996 • 6 citations