Obesity in the new millennium

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

Leptin and the regulation of body weight in mammals

1998 • 5,366 citations

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

1995 • 4,057 citations

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

1995 • 3,730 citations

Body-Mass Index and Mortality in a Prospective Cohort of U.S. Adults

1999 • 3,707 citations

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

1998 • 3,700 citations

Role of leptin in the neuroendocrine response to fasting

1996 • 3,106 citations

Congenital leptin deficiency is associated with severe early-onset obesity in humans

1997 • 2,900 citations

Increasing prevalence of overweight among US adults. The National Health and Nutrition Examination Surveys, 1960 to 1991

1994 • 2,623 citations

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

1998 • 2,333 citations

Body Weight and Mortality among Women

1995 • 2,018 citations

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

1997 • 1,891 citations

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

1998 • 1,666 citations

Increasing Prevalence of Overweight Among US Adults

1994 • 1,479 citations

The role of depot fat in the hypothalamic control of food intake in the rat

1953 • 1,400 citations

Overweight Children and Adolescents: Description, Epidemiology, and Demographics

1998 • 1,382 citations

The Body-Mass Index of Twins Who Have Been Reared Apart

1990 • 1,283 citations

Cerebrospinal fluid leptin levels: Relationship to plasma levels and to adiposity in humans

1996 • 1,004 citations

Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area

1999 • 909 citations

Attenuation of the Obesity Syndrome of ob/ob Mice by the Loss of Neuropeptide Y

1996 • 814 citations

Treatment of Obesity by Moderate and Severe Caloric Restriction: Results of Clinical Research Trials

1993 • 482 citations

Appetite and the regulation of body composition

1994 • 156 citations

The origins and consequences of obesity

1996 • 96 citations

The origins and consequences of obesity

1997 • 95 citations

Metabolic differences and the development of obesity

1995 • 85 citations