Targeting farnesyltransferase: is Ras relevant?

PROTEIN PRENYLATION: Molecular Mechanisms and Functional Consequences

1996 • 1,977 citations

The insulin signaling system.

1994 • 1,733 citations

K- and N-Ras Are Geranylgeranylated in Cells Treated with Farnesyl Protein Transferase Inhibitors

1997 • 848 citations

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

1995 • 831 citations

Protein Prenyltransferases

1996 • 693 citations

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

1998 • 654 citations

Benzodiazepine Peptidomimetics: Potent Inhibitors of Ras Farnesylation In Animal Cells

1993 • 631 citations

Selective Inhibition of ras -Dependent Transformation by a Farnesyltransferase Inhibitor

1993 • 578 citations

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity.

1992 • 542 citations

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

1995 • 533 citations

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

1994 • 523 citations

A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines.

1995 • 393 citations

THE POTENTIAL OF FARNESYLTRANSFERASE INHIBITORS AS CANCER CHEMOTHERAPEUTICS

1997 • 329 citations

Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice.

1998 • 314 citations

Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice.

1994 • 287 citations

Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas

1998 • 278 citations

Rho family GTPases: the cytoskeleton and beyond

1996 • 262 citations

Critical role of Rho in cell transformation by oncogenic Ras.

1995 • 256 citations

Cell Growth Inhibition by Farnesyltransferase Inhibitors Is Mediated by Gain of Geranylgeranylated RhoB

1999 • 255 citations

Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956.

1995 • 241 citations

Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

1997 • 240 citations

Peptidomimetic inhibitors of Ras farnesylation and function in whole cells.

1993 • 222 citations

Evidence that Farnesyltransferase Inhibitors Suppress Ras Transformation by Interfering with Rho Activity

1995 • 220 citations

Farnesyltransferase Inhibitors Alter the Prenylation and Growth-stimulating Function of RhoB

1997 • 214 citations

Non-Ras targets of farnesyltransferase inhibitors: focus on Rho

1998 • 214 citations

Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones

1998 • 212 citations

Farnesyltransferase Inhibition Causes Morphological Reversion of ras-Transformed Cells by a Complex Mechanism That Involves Regulation of the Actin Cytoskeleton

1994 • 197 citations

Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes.

1998 • 191 citations

Farnesyl transferase inhibitors induce apoptosis of Ras-transformed cells denied substratum attachment.

1997 • 184 citations

A Farnesyltransferase Inhibitor Induces Tumor Regression in Transgenic Mice Harboring Multiple Oncogenic Mutations by Mediating Alterations in Both Cell Cycle Control and Apoptosis

1998 • 173 citations

Geranylgeranylated RhoB mediates suppression of human tumor cell growth by farnesyltransferase inhibitors.

1999 • 159 citations

The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts.

1996 • 150 citations

The Ras-related Small GTP-binding Protein RhoB Is Immediate-early Inducible by DNA Damaging Treatments

1995 • 149 citations

Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice.

1998 • 146 citations

Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton.

1994 • 142 citations

The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation.

1994 • 113 citations

Metabolic Turnover of Human c-ras^H p21 Protein of EJ Bladder Carcinoma and Its Normal Cellular and Viral Homologs

1984 • 92 citations

rhoB Encoding a UV-inducible Ras-related Small GTP-binding Protein Is Regulated by GTPases of the Rho Family and Independent of JNK, ERK, and p38 MAP Kinase

1997 • 79 citations

Metabolic turnover of human c-rasH p21 protein of EJ bladder carcinoma and its normal cellular and viral homologs.

1984 • 60 citations

Resistance of a variant ras-transformed cell line to phenotypic reversion by farnesyl transferase inhibitors.

1996 • 47 citations

Dual role of Ras and Rho proteins: At the cutting edge of life and death

1998 • 39 citations